Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037116 (silicosis)
1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cytokines are important mediators of the pathogenesis of lung fibrosis. The experimental studies carried out in our laboratory have used a murine model of lung silicosis to explore the activity of interleukin-9, -10 and -12. The data presented in this short overview illustrate the pro-fibrotic activity of anti-inflammatory cytokines (IL-10), and the role of type 2 immune polarisation, as illustrated by the paradoxical effect of IL-9 and the activity of IL-12 p40 subunit.
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PMID:[Recent findings on the role of cytokines in the pathogenesis of interstitial pulmonary fibrosis]. 1250 16