Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of 102 cases of diffuse or peripheral lung lesions examined by transbronchial lung biopsy (TBLB), bronchial brushing (BB), and bronchial alveolar lavage (BAL) via fiberoptic bronchoscope, were reported. The positive diagnostic rate was 74.5% (76 cases). In lung cancer, the positive rate by means of BB was 77.1%, which was higher than that by TBLB (58.1%). In pulmonary tuberculosis, the positive rate by TBLB was 76.9%, higher than that by BAL fluid for identification of tubercle bacillus by culture (44.4%). If TBLB was combined with BB and BAL, the positive diagnostic rate would be further elevated. The data showed that if the size of the masses greater than or equal to 3cm in peripheral lung field on chest film, the possibility of lung cancer was greater than that of those less than 3cm. Most cases of localized infiltration in the lungs were caused by tuberculosis. But the diffuse lesions of the lungs were often caused by bronchiolo-alveolar carcinoma, adenocarcinoma, diffuse interstitial fibrosis of the lungs, silicosis, sarcoidosis, etc. By the careful study of the chest film and ascertainment of the exact locations of the pulmonary lesions there, we can carry out the TBLB and obtain a satisfactory specimen without any X-ray monitoring. In the present group of patients who underwent TBLB, one was complicated by haemorrhage (greater than 50ml) and two by pneumothorax, but all of them recovered promptly after proper management. By strick adherence to indication, adequate preoperative preparations and very careful performance of the procedure, the complications of TBLB could be reduced to minimum.(ABSTRACT TRUNCATED AT 250 WORDS)
Hua Xi Yi Ke Da Xue Xue Bao 1990 Sep
PMID:[Diagnostic value of transbronchial lung biopsy in diffuse or peripheral lung lesions]. 209 76

An experimental silicosis model was produced in rats by intratracheal instillation of 25 mg silica dioxide normal saline. Animals were killed at 1, 3, 7, 14, 45 days after treatment, for cytological, enzyme cytochemical and biochemical analyses of the bronchoalveolar lavage fluid. The results showed that the number of polymorphonuclear cells and alveolar macrophages (AMs) increased continuously. The total amount of protein and activities of LDH and AcP in the lavage fluid were elevated, while the activities of LDH, SDH and AcP demonstrated by enzyme cytochemical staining in AMs were lowered. The survival rate of AMs decreased and foamy AMs appeared, these changes reflected the main characteristics of silica-induced alveolitis. We conclude that silica-induced alveolitis is not only the essential pathological characteristics of early pulmonary reaction to silica, but also plays a crucial role in the pathogenesis of silicotic fibrosis.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Mar
PMID:[Effect of bronchoalveolar lavage fluid on silica-induced alveolitis in rats]. 236 38

Measuring DL COSB of 120 normal subjects by using a gas mixture, in which helium was replaced by argon, we determined the DL COSB mean value, standard deviation and the predicted value formula for both sexes. The lower limit value of DL COSB for normal subjects was defined and the positive diagnostic value investigated. A ratio of actual value to predicted value below 80% was defined as abnormal. With this diagnostic criterion 43 cases of silicosis and diffuse pulmonary interstitial fibrosis were investigated, the positive rate of the cases being 90.70%, with a false positive rate of below 10% for normal subjects, which indicates that this gas mixture and the criterion are applicable for clinical practice.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Mar
PMID:[Argon replacing helium in measurement of pulmonary carbon monoxide diffusing capacity, its normal value and clinical application]. 236 47