Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0037116 (
silicosis
)
1,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Millions of individuals worldwide are afflicted with acute and chronic respiratory diseases, causing temporary and permanent disabilities and even death. Oftentimes, these diseases occur as a result of altered immune responses. The
aryl hydrocarbon receptor
(
AhR
), a ligand-activated transcription factor, acts as a regulator of mucosal barrier function and may influence immune responsiveness in the lungs through changes in gene expression, cell-cell adhesion, mucin production, and cytokine expression. This review updates the basic immunobiology of the
AhR
signaling pathway with regards to inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease, and
silicosis
following data in rodent models and humans. Finally, we address the therapeutic potential of targeting the
AhR
in regulating inflammation during acute and chronic respiratory diseases.
...
PMID:Role of the aryl hydrocarbon receptor (AhR) in lung inflammation. 2396 93
