Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ore containing cummingtonite-grunerite has been mined to extract gold since 1876 in Lead, South Dakota. Each of the 1,321 men who were recorded as having worked 21 years or more with the Homestake Mine was allocated to one of 5 dust-exposure categories on the basis of work history and available information on environmental conditions. All except 9 men were traced to the end of 1973, when 652 were still living; the cause of death was ascertained for 657 of the 660 men who had died. Deaths from cerebrovascular accidents and malignant disease were close to the numbers expected and from accidents and other causes were fewer than expected, but in each of the 3 diagnostic groups--pneumoconiosis (mainly silicosis), tuberculosis, and heart disease--there were more than 30 excess deaths. A clear dust-exposure relationship was found for pneumoconiosis and respiratory tuberculosis--with relative risks for the 2 groups with greatest exposure to dust as compared to the 2 with least exposure, of 19.9 and 16.0, respectively, but there was no convincing evidence of an increase in respiratory cancer.
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PMID:Mortality after long exposure to cummingtonite-grunerite. 21 90

Recognized specific risks of industry considered.Under Section 73, Factory and Workshop Act, certain diseases contracted in a factory or workshop are notifiable by medical practitioners to the Chief Inspector of Factories.Lead poisoning, epitheliomatous and chrome ulceration and anthrax-considered in detail.Effects of inhalation of dust in the causation of silicosis and asbestosis. Relation of these diseases to tuberculosis. Reason to believe that a large number of dusts of different characters will create pathological changes in the lung.Other diseases included in the Schedule under the Workmen's Compensation Act, e.g., nystagmus and dermatitis.Common risks, i.e., shared by the general non-industrial population, incurred by workers.Direct supervision of workers in industry.The sphere and work of a works medical officer. The effects of National Health Insurance on such service. Co-operation between panel and works doctors. Far-reaching effects of the services rendered by works medical officers.Periodic medical inspection under regulations for dangerous trades. Advice given on all medical matters.The charge that industry raises the cancer incidence considered. Means of controlling early recognition and treatment include some non-industrial cases of cancer.Anthrax in industry led to the introduction into the country of Sclavo's serum. Disinfection of wool protects the consumer.First-aid training in factories gives protection in the home.It is suggested that well-organized industry is a centre radiating the principles of preventive medicine.
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PMID:The Influence of Industry on Public Health. 1998 74