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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and seventeen cases of tuberculous disease who came to the Authors' observation in 10 years are described. Some cases are illustrated in details just to point out the complexity and the different guises of clinical presentation and to underscore the importance of an high index of suspicion for tuberculosis in patients who are admitted to a ward of internal medicine. In 71 patients with active, progressive tuberculous disease, the diagnosis was confirmed by bacteriological findings in 29 cases and by bioptical and hystological data in 5 cases; in the remaining 37 cases only clinical and radiological criteria were met but the diagnosis was confirmed by the improvement which was observed after antimycobacterial therapy. Many difficulties have been met in the differential diagnosis between pulmonary tuberculosis and bronchogenic carcinoma in those cases with anamnestic and radiological data of previous pulmonary tuberculosis. When the radiological site of lesions was in the posterior segments of the lung, tuberculosis was the most probable diagnosis, while bronchogenic carcinoma is most oftenly localized in the anterior segments; only in 5 cases of the Author's series the above mentioned criterion was not satisfied. In 46 cases with clinical signs of inactive tuberculous disease which had not been adequately treated with chemotherapy, isoniazid was given only to those patients with a high risk of reactivation (silicosis, diabetes, chronic alcholism, gastric resection, prolonged steroid therapy). Two cases of isoniazid hepatitis were observed among patients treated by the Authors.
Minerva Med 1979 Sep 29
PMID:[Current status and problems of tuberculosis. 10 years of experience in a general medicine department]. 11 91

Lung dusts were investigated, post-mortem, in twenty-five miners from mixed metal mines, tunnels, and quarries who had exposed to high concentrations of mixed dust containing about 20-25% free crystalline silica. The character of the relations found between the amount of quartz per 100 g dry tissue and the clinical, X-ray and pathological findings is similar to that established in coal miners. The difference lies in the fact that with equal amounts of quartz per 100 g dry tissue, there is less silicosis in coal miners than in our cases; the average residence time of retained dust is longer in coal miners, but its quartz per cent is lower.
Inhaled Part 1975 Sep
PMID:Characteristics of lung dusts and their relation to dust exposure and pathological findings in the lungs. 19 69

Short term organ cultures of lung fragments from neonatal mice maintain their normal architecture. Cultures exposed to silica flour in varying concentrations show effects resembling those seen in chronic silicosis produced by inoculation and inhalation methods.
Experientia 1978 Sep 15
PMID:Response of neonatal mouse lung in organ culture to silica. 21 31

The causes and historical background of the high incidence of severe silicosis among pottery workers in the Stoke-on-Trent area are described. The pathogenesis, pathology, and clinical manifestations of the disease are discussed. Although the incidence of silicosis in the Potteries has declined spectacularly in the past 20 years with the introduction of preventive measures, there still remains a generation of middle-aged and elderly potters with the disease who pose special problems for the anaesthetist and the thoracic surgeon.
Ann R Coll Surg Engl 1979 Sep
PMID:Anaesthesia and the potter. 38 92

In order to evaluate low serum alpha-1-antitrypsin level as a contributory factor of combined emphysema in silicotic patients, serum alpha-1-antitrypsin analysis was carried out in 80 patients with silicosis. Low serum alpha-1-antitrypsin level was found in 5 patients. Large opacities were observed roentgenologically in only 1 out of these 5 cases in contrast to 31 of the other 75 cases. Also the suggestive findings for the emphysema were showed in 4 of these 5 cases while such findings were found on their chest X-ray films in only 43 of the other 75 cases. FEV 1.0% below 50 were calculated in 3 of the 5 cases, on the contrary in 22 of the 75 cases. RV above 50% predicted value was showed by all the 5 low antitrypsin patients, in contrast to only 25 of other 74 cases. The silicotic patients with low serum alpha-1-antitrypsin concentration are most likely to have an association with a high incidence of complicated emphysema.
Tohoku J Exp Med 1975 Sep
PMID:Low serum alpha-1-antitrypsin level as a contributory factor of combined emphysema in silicosis. 108 Dec 85

Such an association would not appear to be fortuitous since scleroderma is commoner in male miners than in women in general, whilst the predominance of the disease in the latter group is well known. The picture is that of generalised scleroderma without any special characteristics. Silicosis usually precedes the scleroderma. In general, the onset of scleroderma alters the chest X-ray appearance with the development of diffuse, non-cavitated macro-nodular opacities localised in the lower two-thirds of the lungs and in particular at the bases, without absolute symmetry. Several hypotheses may be advanced to explain this association. Irritation by dust in the presence of a particular underlying terrain may cause silicosis and the same terrain may be associated with the development of scleroderma. A second possibility is that of immune phenomena secondary to the pneumoconiosis which favourise the development of scleroderma.
Nouv Presse Med 1975 Sep 13
PMID:[Silicosis associated with scleroderma]. 117 57

Lung function tests (forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC %) were related to silica exposure and the extent of radiological opacities in a study of 206 active and 132 previously employed granite workers from two quarries. The investigations included detailed personal interviews, spirometric testing and radiographic examination of the chest. The chest X-ray films were read randomly and independently by three readers, using International Labour Office (ILO) standard films. Cumulative exposure to respirable silica (mg.m-3-yr) and total granite dust (million particles per cubic foot (mppcf-yr)) were estimated for each subject based on his years of employment at various jobs and historical and current measurements of quarry-, period- and job-specific exposures. The results suggest that chronic simple silicosis, especially for profusion category 2 and 3, was associated with significant lung function loss. As expected, mixed dust fibrosis was associated with little or no functional disturbance. Massive fibrosis was associated with significant obstructive and restrictive impairment. No additional effect of exposure to respirable silica on lung function loss was found after allowing for the presence of "silicosis". However, exposure to total dust (mppcf-yr) appeared to be associated with some lung function loss independent of silicosis. Our results indicate that chronic simple silicosis is not a benign disease; silica exposure is the primary cause, but the lung function loss in silicotics is directly attributable to the fibrotic lung disease. However, exposure to total granite dust beyond the respirable size range may separately produce additional lung function loss.
Eur Respir J 1992 Sep
PMID:Lung function in relation to silicosis and silica exposure in granite workers. 133 Jun 77

After successful animal studies since 1986, a single left lung transplantation was performed on a 35-year-old male patient with end-stage silicosis in July 1991. The surgical technique was similar to that used by the Toronto Transplant Group, except for some modification in bronchial anastomosis. The donor lung was preserved by simple surface cooling after the administration of heparin, methylprednisolone and PGE1. The ischemic time for the donor lung was 3.5 hours. A cardiopulmonary bypass through the femoral vessels was applied for a duration of 90 minutes. Immediate postoperative complications included massive bleeding, disseminated intravascular coagulation, adult respiratory distress syndrome and acute graft rejection. Fortunately, we overcame these complications through intensive care. Immunosuppression included antilymphocytic globulin, cyclosporine, azathioprine and corticosteroids. The results of this single lung transplantation were satisfactory. The patient was doing well and was able to satisfactorily breathe room air six weeks after the transplantation. Unfortunately, the patient died of opportunistic systemic aspergillosis six months after the transplantation. In conclusion, lung transplantation is an effective treatment for patients with end-stage lung diseases, and the results of this first single lung transplantation in Taiwan are encouraging and promising.
J Formos Med Assoc 1992 Sep
PMID:Single lung transplantation for end-stage silicosis: report of a case. Lung Transplant Group. 136 97

In recent years, with the aging of patients with pneumoconiosis, autoimmune diseases as a complication have been observed. One of the reasons for this may be that autoimmune diseases are prone to develop among the elderly. On the other hand, it has been reported that dust itself, such as silica for example, has adjuvant effect. A review of the recent literature published in Japan and abroad was made to clarify the relationship between pneumoconiosis and autoimmune diseases and the following results were obtained. 1) Disorders which accompany pneumoconiosis: Scleroderma, rheumatoid arthritis, systemic lupus erythematosus (SLE), and disorders of the kidney and liver have been reported. In Japan, about 30 cases of pneumoconiosis accompanied with autoimmune diseases have been reported. In many of the reports, patients with pneumoconiosis and scleroderma have a past history of exposure to silica. In both case studies and case control studies, patients with rheumatoid arthritis and history of silica exposure are prone to develop pneumoconiosis. 2) Immunological studies of patients with pneumoconiosis: As for humoral immunity, elevation of polyclonal gamma-globulin, especially IgG, has been often reported together with high positive rate of autoantibodies such as antinuclear antibodies. In cellular immunity, decreased delayed type skin reaction and decreased CD4/8 ratio have been reported. In human leukocyte antigen (HLA) typing the elevated frequency of DR4 has been reported. In the study of BAL increased production of superoxide anion O2- by alveolar macrophages has been observed. 3) EXPERIMENTAL STUDIES: Silica is well known for its toxicity to cells and also for its adjuvant effect. In the German Democratic Republic, patients with scleroderma and history of long term silica exposure are recognized as patients with occupational disease even though pneumoconiosis is not clearly demonstrated on X-ray film. It is difficult from this review to nrake a definite conclusion regarding the relation between silicosis and autoimmune diseases. There is a need to repeat this review of the literature on autoimmune diseases and pneumoconiosis in the near future.
Sangyo Igaku 1992 Sep
PMID:[Relationship between autoimmune diseases and pneumoconiosis]. 140 2

During 1963-1990 professional disease were registered in 336 sinkers (vibration disease--42.6%; hypoacusis--35.1%; silicosis and dust-induced bronchitis--11.3 and 7.4% respectively). The mean morbidity level of professional diseases in sinkers was 12.0 per 1000 (vibration disease--4.9, hypoacusis--6.4). The level of silicosis reduced 2.9 times.
Lik Sprava 1992 Sep
PMID:[The working conditions and occupational morbidity of tunnellers engaged in the construction of underground mining installations]. 148 19


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