Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The elevated risk of tuberculosis in subjects with silicosis is widely accepted but has not been quantified in a population with a high prevalence of tuberculosis. In this study, a cohort of 1,153 older gold miners with and without silicosis who had not had tuberculosis have been followed for 7 yr by a routine mine surveillance program for detection of tuberculosis. One hundred seventy-eight of the men developed tuberculosis. The annual incidence of tuberculosis was 981/100,000 in the 335 men without silicosis and 2,707/100,000 in the 818 men with silicosis. The relative risk for tuberculosis was 2.8 (95% CI, 1.9 to 4.1) for men with silicosis compared with that in the men without silicosis. The incidence of tuberculosis increased from 1% per annum (pa) for the men without silicosis to 2.2% pa for the men with silicosis with Category 1 nodule profusion, 2.9% pa for those with Category 2, and 6.3% pa for those with Category 3 silicosis. This study has confirmed and quantified the high risk of pulmonary and of extrapulmonary tuberculosis in men with silicosis. The incidence of tuberculosis during this 7-yr study suggests that one quarter of these men with silicosis will have developed tuberculosis by 60 yr of age.
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PMID:The epidemiology of tuberculosis in gold miners with silicosis. 795 77

The paper provides primary and secondary disability rates during 5 years (1993-1997), derived by the tuberculosis agency of a Moscow sociomedical examination commission. Examination was made mainly in patients with pulmonary and extrapulmonary tuberculosis, chronic nonspecific lung diseases, silicosis, cancer, and concomitant diseases of the heart, liver, kidney, etc. There was a rise in primary and secondary disability rates due to the increases of Groups 2 and 3. More than 50% of the patients do not work as unemployment is on the rise in Russia. Group 3 patients were the smallest proportion and temporarily disabled patients were also few.
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PMID:[Sociomedical examination and rehabilitation of patients with tuberculosis]. 1164 55