Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with hereditary spherocytosis and silicosis who developed an IgA(lambda) monoclonal gammopathy is reported. It was thought that a combination of hereditary factors, a chronic hemolytic stimulus to the reticuloendothelial system and an adjuvant effect provided by presence of diffuse silica might have contributed to the development of monoclonal gammopathy.
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PMID:A patient with hereditary spherocytosis and silicosis who developed an IgA(lambda) monoclonal gammopathy. 357 11

Silicosis is a chronic, progressing disease of the respiratory system. The aim of this paper was to describe a case of silicosis coexisting with not typical plasmocytoma. Silicosis was diagnosed in a 62-year old woman, after an 8-year employment as a grinder. The patient has suffered from progressing weakness, fatigue, and dyspnea for 2 years. The increased leucocytosis (18-20,000) and moderate lymphocytosis were found in laboratory tests. The patient was admitted to the hospital in a very serious condition, with fever and progressing insufficiency of the respiratory and circulatory systems. Following computed tomography (CT), tumorous silicosis was diagnosed in the Department of Internal and Occupational Diseases. After three months, the increased level of the whole number of serum proteins (until 90 g/l) was found for the first time together with few places of osteolysis in the x-ray cranium picture. The plasmocytoma infiltrations were found in the post-mortem lung examination. The described case seems to be interesting in view of a possible induction of monoclonal gammopathy by silicosis.
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PMID:[A case of lung silicosis associated with plasmocytoma: the diagnosis and certification difficulties]. 1466 79