Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0037116 (
silicosis
)
1,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BACKGROUND:
For over one hundred years, the gold mining sector has been a considerable source of tuberculosis (TB) and
silicosis
disease burden across Southern Africa. Reading chest radiographs (CXRs) is an expert and time-intensive process necessary for the screening and diagnosis of lung disease and the provision of evidence for compensation claims. Our study explores the use of computer-aided detection (CAD) of TB and
silicosis
in CXRs of a population with a high incidence of both diseases.
METHODS:
A set of 330 CXRs with human expert-determined classifications of
silicosis
, TB, silcotuberculosis and normal were provided to four health technology companies. The ability of each of their respective CAD systems to predict disease was assessed using receiver operating characteristic curve analysis of the under the curve metric.
RESULTS:
Three of the four systems differentiated accurately between TB and normal images, while two differentiated accurately between
silicosis
and normal images. Inclusion of
silicotuberculosis
images reduced each system's ability to detect either disease. In differentiating between any abnormal from normal CXR, the most accurate system achieved both a sensitivity and specificity of 98.2%.
CONCLUSION:
The current ability of CAD to differentiate between TB and
silicosis
is limited, but its use as a mass screening tool for both diseases shows considerable promise.
...
PMID:Computer-aided detection for tuberculosis and silicosis in chest radiographs of gold miners of South Africa. 3231 57
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