Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multiple different types of anterior mediastinal masses may be encountered on computed tomography (CT) imaging, and many of these lesions are neoplastic in etiology. These include masses arising from the thymus, thyroid and parathyroid glands, as well as lymph nodes, pericardium, and vessels and nerves. Often, the CT attenuation of the mass can be helpful in narrowing down the differential diagnosis, and attenuation values suggesting fat, water or calcium may suggest certain diagnoses; significant enhancement of the mass with intravenous contrast may also be a helpful feature. Lesions with fatty attenuation include teratomas, thymolipomas and Morgagni hernias. Lesions that may manifest the attenuation of water include pericardial and thymic cysts, abscesses, and lymphangiomas, as well as neurogenic and germ cell tumors. Multiple types of lesions may contain calcium, including thyroid goiters and cancers, thymomas, thymic carcinomas and carcinoids, treated lymphoma, germ cell tumors, parathyroid adenomas, and lymph nodes involved with silicosis, sarcoid, tuberculosis, fungal diseases and pneumocystis. Contrast enhancement may be seen in lesions of vascular origin and in vascular neoplasms, such as parathyroid adenomas and Castleman's disease. In addition to CT attenuation values, the exact location and morphology of the mass in question, in conjunction with clinical features such as patient age, gender, signs, symptoms, and laboratory values, can usually lead to a short list of possible etiologies, thereby directing appropriate additional diagnostic procedures or therapeutic approaches.
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PMID:Imaging of anterior mediastinal masses. 1792 Oct 91

Lymphadenopathy is a common radiological finding in many thoracic diseases and may be caused by a variety of infectious, inflammatory, and neoplastic conditions. This review aims to describe the patterns of mediastinal and hilar lymphadenopathy found in benign diseases in immunocompetent patients. Computed tomography is the method of choice for the evaluation of lymphadenopathy, as it is able to demonstrate increased size of individual nodes, abnormalities of the interface between the mediastinum and lung, invasion of surrounding fat, coalescence of adjacent nodes, obliteration of the mediastinal fat, and hypo- and hyperdensity in lymph nodes. Intravenous contrast enhancement may be needed to help distinguish nodes from vessels. The most frequent infections resulting in this finding are tuberculosis and fungal disease (particularly histoplasmosis and coccidioidomycosis). Sarcoidosis is a relatively frequent cause of lymphadenopathy in young adults, and can be distinguished from other diseases - especially when enlarged lymph nodes are found to be multiple and symmetrical. Other conditions discussed in this review are silicosis, drug reactions, amyloidosis, heart failure, Castleman's disease, viral infections, and chronic obstructive pulmonary disease.
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PMID:Thoracic lymphadenopathy in benign diseases: A state of the art review. 2686 Feb 19