Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0037116 (
silicosis
)
1,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Our objective was to examine the relationship between
silicosis
and
esophageal cancer
in Hong Kong. The mortality of
esophageal cancer
was investigated among caisson and non-caisson workers in a cohort of 2,789 male silicotic workers in Hong Kong during the period 1981-99. The standardized mortality ratio (SMR) was calculated using the Hong Kong general population rates as reference. The indirect method proposed by Axelson was used to adjust for the confounding effects of cigarette smoking and alcohol drinking. The SMR of
esophageal cancer
in the entire cohort was 2.22 (95% CI 1.36-3.43, based on 20 deaths) and was 4.21 (95% CI 1.81-8.30, based on 8 deaths) in the subgroup of caisson workers who had a higher exposure to silica dust. The relative risk of
esophageal cancer
for caisson silicotics was reduced to 2.34 after adjusting for the effects of smoking and alcohol drinking. No more excess risk of
esophageal cancer
was observed among non-caisson silicotic workers after the adjustments. This historical cohort study revealed that there was an increased mortality risk of
esophageal cancer
among silicotics who had worked in underground caissons in Hong Kong after adjusting for cigarette smoking and alcohol drinking. We believe that the excess risk of
esophageal cancer
mortality among caisson workers with
silicosis
could best be explained by the very heavy exposure to free silica dust in their working environment.
...
PMID:Further evidence for a link between silica dust and esophageal cancer. 1557 19
