Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A pilot study was performed to assess the prevalence of hyperreactive bronchial system (HBS) in various occupational lung diseases. 204 patient records were evaluated with the following diagnosis: Allergic rhinitis: (N = 25, 12%), allergic bronchial asthma (N = 70, 34%), toxic asthma (N = 22, 11%), silicosis (N = 12, 6%), asbestosis (N = 15, 7%), farmer's lung (N = 12, 6%), chronic unspecific respiratory syndrome (N = 48, 24%). In each case an inhalative methacholine test (MCHT) was performed. HBS was considered to be present whenever there was a resistance increase of more than 100% of the baseline values. The prevalence of HBS varied between 50% (asbestosis) and 77% (toxic asthma); the average was 68%. Allergic diseases showed a higher prevalence of 71% in comparison to nonallergic diseases with 65%. Patients with silicosis or asbestosis and without additional chronic bronchitis or emphysema demonstrate a "normal" prevalence of HBS of 11%. Age, gender, smoking, alcohol, family history of allergy and repeated bronchitis, the number of eosinophils in the blood. IgE concentration in serum showed no significant association with an increased prevalence of HBS. The coincidence of anamnestically affirmed or denied bronchial hypersensitivity to environmental factors, and the positive or negative result of the MCHT test, was relatively low, being only 43% in case of a "positive" test and 17% in case of a "negative" test.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Pilot study of the prevalence of a hyperreactive bronchial system in various occupationally-induced lung diseases]. 238 88

Dust storms may originate in many of the world's drylands and have an effect not only on human health in the drylands themselves but also in downwind environments, including some major urban centres, such as Phoenix, Kano, Athens, Madrid, Dubai, Jedda, Tehran, Jaipur, Beijing, Shanghai, Seoul, Taipei, Tokyo, Sydney, Brisbane and Melbourne. In some parts of the world dust storms occur frequently throughout the year. They can transport particulate material, pollutants, and potential allergens over thousands of km from source. The main sources include the Sahara, central and eastern Asia, the Middle East, and parts of the western USA. In some parts of the world, though not all, the frequency of dust storms is changing in response to land use and climatic changes, and in such locations the health implications may become more severe. Data on the PM10 and P2.5 loadings of dust events are discussed, as are various pollutants (heavy metals, pesticides, etc.) and biological components (spores, fungi, bacteria, etc.). Particulate loadings can far exceed healthy levels. Among the human health effects of dust storms are respiratory disorders (including asthma, tracheitis, pneumonia, allergic rhinitis and silicosis) cardiovascular disorders (including stroke), conjunctivitis, skin irritations, meningococcal meningitis, valley fever, diseases associated with toxic algal blooms and mortality and injuries related to transport accidents.
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PMID:Desert dust and human health disorders. 2427 7