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Query: UMLS:C0037090 (Respiratory symptoms)
 467 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Respiratory symptoms among six employees in wool dye-houses in the United Kingdom were investigated. Clinical histories revealed that all had work-related respiratory symptoms, which they associated with exposure to Lanasol dyes. Five of the six subjects had specific Immunoglobin E to human serum albumin conjugates of one or more of the dyes to which they were exposed, providing evidence of sensitization to these dyes. In two subjects there was a definite association between symptoms to a particular dye, and specific IgE to an albumin conjugate of that dye. Specific IgG was found in exposed subjects, irrespective of the presence of allergic symptoms, indicating that specific IgG reflects exposure rather than clinical sensitization. Four of the six subjects had specific IgG4; this was only present in the subjects with respiratory allergy and specific IgE.
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PMID:Respiratory allergy and specific immunoglobin E and immunoglobin G antibodies to reactive dyes used in the wool industry. 260 84

Thirty-five patients with seasonal pollen rhinitis due to hypersensitivity to Parietaria officinalis pollen were randomized and treated with ketotifen and with a combination of ketotifen and beclomethason diproprionate, a nasal steroid. The study was timed to cover the Parietaria off. pollination period (4 months), which was documented by the determination of air concentration of the pollen. Respiratory symptoms and additional medications were scored according to a defined control. During the peak pollen period, both groups suffered from intensified pollinosis symptoms which prompted additional medication. The increases, however, were less significant in the group treated with the combination of the two drugs, i.e. better results were obtained with the ketotifen-beclomethasone diproprionate combination than with ketotifen alone.
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PMID:[Ketotifen and nasal steroids in the therapy of pollinosis]. 263 8

120 children, 71 male and 49 female, aged between 2 years and 15 years (mean 6.15 +/- 3.52 years) with recurrent respiratory infections, were treated with Immucytal, an immunomodulator of bacterial origin, based on membrane proteoglycan fractions plus bacterial ribosomes. The children, selected on the basis of the previous year's clinical score, were treated according to a random design with either Immucytal or placebo, using the same dosage of one puff per nostril plus one puff in the oropharyngeal cavity three times a day, as follows: 1st month: two weeks' treatment, one week wash out, one week's treatment. 2nd, 3rd, 4th months: two weeks' treatment, two week's wash out. Monthly throughout the treatment period the frequency and severity of airway infections episodes were assessed using the same score as for admission. Blood chemistry test, immunological assays (circulating Ig, lymphocyte subpopulations, Merieux Multitest in vivo blastization test) and respiratory tests (spirometry using a pneumotachigraph) were done before and after the treatment. 118/120 children completed treatment; the two dropouts were in the placebo group, one for compliance and the other because of headaches. Respiratory symptoms improved significantly in the actively treated children already from the first month, but not in the placebo group. This improvement consisted of reduction of the respiratory infectious episodes in both the upper and lower airways. No changes were noted in respiratory function parameters. From the immunological viewpoint, there were significant rises in serum IgA and IgM and enhanced skin response tot he Multitest; there was no change in the percentages of different circulating lymphocyte subpopulations.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Treatment using immucytal in children with recurrent respiratory infections: an Italian multicenter experience]. 268 18

Respiratory symptoms in cystic fibrosis are both local and systemic. The local symptoms include cough, sputum, wheezing, haemoptysis and breathlessness, while systemic symptoms of malaise and fever occur with pulmonary infection. There are also interactions between respiratory and gastrointestinal systems in producing symptoms of malaise and weakness and these also contribute to the secondary psychological and social problems that a number of patients with cystic fibrosis experience. These local respiratory symptoms can be attributed in part to lung damage, but are also a manifestation of the CF defect itself. Similarly, lung damage, allergy, haemodynamic and nutritional changes all contribute to the symptom of breathlessness. Further improvement in symptoms in the future will come not only from limiting the lung damage but also from therapy aimed at reversing the CF defect itself.
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PMID:Cystic fibrosis--from lung damage to symptoms. 270 25

In 1985, employees in the china clay industry were offered chest x ray examinations and 4478 (52.6% of the total workforce) accepted. Of these, 4167 workers and pensioners of the largest single employer also completed occupational histories, respiratory symptom questionnaires, and underwent ventilatory capacity tests. The x ray readings (read to the 1980 ILO classification) of the 4167 workers and pensioners were analysed to seek relations between the indices of pulmonary health and occupational exposure. The information available, particularly on occupational history, was more detailed than in previous studies of 1961, 1977, and 1981. Analyses show that in the improved operating conditions of recent years the average worker exposed to dust only after 1971 would not expect to develop category 1 pneumoconiosis through a full working life in any of the industry's occupations. For those with exposure before 1971 the category reached will depend on the amount of early exposure, but the rate of development of pneumoconiosis since 1971 is about half that before 1971. The milling of china stone, a practice that ceased over 15 years ago in the china clay industry, had by far the largest effect on x ray category, whereas of the current occupations, employment in china clay attritor mills has the greatest effect. Ventilatory capacity is related to x ray category as well as age, and results for loss of ventilatory capacity in relation to age, x ray category, and smoking habits were similar to the results in previous studies. Respiratory symptoms are associated with smoking class and a loss in ventilatory capacity (FVC or FEV1), FEV1 being the most dominant. Allowing for this, there was no further effect for years of exposure, x ray category, or age.
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PMID:China clay workers in the south west of England: analysis of chest radiograph readings, ventilatory capacity, and respiratory symptoms in relation to type and duration of occupation. 271 82

A study was made of the smoking habits of 10,349 teenagers attending secondary school in Grande-Terre, Lamentin and Marie-Galante in Guadeloupe (41.4% were male; mean age 16.4 +/- 1.8). The study was made using a self administered questionnaire which also included questions on respiratory symptoms in teenagers and the smoking habits of their parents. The proportion of regular smokers (greater than one cigarette per day) was 9.2% in boys and 5.6% in girls: the boys were smoking on average 7.3 cigarettes a day, the girls 5.9. The proportion of smokers increased with age, being the highest in the children of managerial and commercial classes or skilled artisans, and was strongly linked to the smoking habits of the parents. Respiratory symptoms were more common in teenagers who smoked.
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PMID:[Smoking in adolescents in Guadeloupe]. 272 68

Patients with achalasia tolerate considerable distension of the esophagus. Respiratory symptoms usually are due to regurgitation and pulmonary aspiration of retained food rather than to a space-occupying mechanism. We describe a case of previously undiagnosed achalasia presenting in an elderly woman with symptoms consistent with tracheal obstruction of acute onset.
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PMID:Acute airway obstruction and achalasia of the esophagus. 276 48

Seventeen cases of pediatric malignant neoplasm with pulmonary and/or pleural lesions shown by chest radiography at initial diagnosis were reviewed and analyzed. Respiratory symptoms such as dyspnea, tachypnea, and chest pain were observed on admission in approximately one-half of them. The initial chest radiography showed pleural lesions in 7 of the 17, pulmonary lesions in 8, and both pulmonary and pleural lesions in 2. Unilateral or bilateral pleural fluids were observed in all of the seven patients with pleural lesions, and malignant cells were confirmed in the pleural fluid of all patients. The radiographic patterns of the eight patients with pulmonary lesions were solitary nodule in two, multiple nodules in two, diffuse miliary nodules in three, and diffuse honeycomb in one. Histological examination of the pulmonary lesion was performed in six patients at the initial diagnosis or after death, while in the remaining two primary or other metastatic sites were examined. The two patients with both pulmonary and pleural lesions showed multiple nodules or infiltrates with pleural fluid on chest radiography. Increased malignant cells were detected in the pleural fluid of both patients. In all cases, the lesions gradually or rapidly disappeared with multidrug chemotherapy. The review confirms the need for a combination of complete radiographic and pathological analysis at the time of initial diagnosis of malignant neoplasm in children to distinguish other causes such as infectious complications.
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PMID:Pulmonary and pleural involvements at initial diagnosis in children with malignant neoplasm. 278 53

To examine the relationship between bronchial hyperresponsiveness (BHR) and respiratory symptoms associated with asthma, we studied a sample of 380 schoolchildren on three occasions at 2-yr intervals. The age of the children at the first study was 8-10 yr. Respiratory symptoms history was assessed by questionnaire, BHR was measured by a histamine inhalation test and atopy was assessed by skin-prick tests to 13 allergens. The cumulative prevalence of BHR in this sample was 27%. The severity of BHR was categorized as severe, moderate, mild or slight. The distribution of severe, moderate and mild BHR was similar at each of the studies. At the third study, when the children were aged 12-14 yr, the prevalence of slight BHR decreased. Children with severe or moderate BHR at age 8-10 yr were atopic, reported current symptoms during the 4 yr of the study and had a high prevalence of severe or moderate BHR in later studies. In this group, 87% of children had current respiratory symptoms and 73% were using asthma medication at age 12-14 yr. In children with mild or slight BHR when first studied, the prevalence of atopy, continuing respiratory symptoms and medication use was much lower. We conclude that severe or moderate BHR is an important risk factor for ongoing morbidity and that comparisons of the prevalence of this severity of BHR in populations may be more informative than comparisons of BHR defined by present criteria.
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PMID:A prospective study of bronchial hyperresponsiveness and respiratory symptoms in a population of Australian schoolchildren. 278 41

The role of childhood respiratory infections before 12 yrs of age (CRI) and during adolescence-adulthood (ARI) was studied in a general population sample (n = 3,289), living in an unpolluted area of Northern Italy. The presence of respiratory symptoms and diseases, as well as risk factors for obstructive airways disease (OAD), was assessed by a standardized questionnaire. Forced vital capacity and derived expiratory flows, and single-breath diffusing capacity were measured using computerized instrumentation. There were 1,185 (36.2%) subjects who reported pertussis (PT), 374 (11.4%) recurrent chest colds, pneumonia and croup, singly or in combination, with or without pertussis (CRI), and 1,718 (52.4%) reported no respiratory infections in childhood (NOCRI). Prevalence rates of respiratory symptoms and diseases were significantly higher in subjects of the CRI group in all ages, and in older smokers. Wheeze and attacks of shortness of breath with wheeze were significantly higher in younger nonsmoking subjects with a history of CRI. Respiratory symptoms and diseases were not more prevalent in subjects of the PT group. Prevalence rates of respiratory symptoms and diseases were significantly higher in subjects with a history of ARI, both in smokers and nonsmokers. Lung function parameters adjusted for sex, age and smoking were significantly lower in CRI subjects; PT subjects showed lower values than NOCRI subjects. A significantly higher prevalence rate of ARI was present in subjects who reported CRI, both in smokers and nonsmokers. Subjects with both CRI and ARI showed the highest prevalence of respiratory symptoms and diseases. In addition, they had the lowest lung function values regardless of smoking habit.
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PMID:Effects of childhood and adolescence-adulthood respiratory infections in a general population. 278 99


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