Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
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Human Gene/Protein
transmembrane emp24 protein transport domain containing 7 9.1
zinc finger and BTB domain containing 17 9.1
F-box only protein 15 9.1
ANKRD42 9.1
C6orf192 9.1
AKIRIN1 9.1
PROC1 9.1
KIAA1737 9.1
Pellino-3 9.1
Pellino-2 9.1
cyclic adenosine 3',5'-monophosphate response element binding protein 8.1
KIAA0317 8.1
serum-derived hyaluronan-associated protein 8.1
zinc finger protein 222 8.1
FcGR 8.1
Carboxypeptidase, vitellogenic-like 8.1
DEFB123 8.1
ZDHHC6 7.5
RNFT2 7.5
ZNF84 7.5
mediator complex subunit 25 7.5
EFCAB7 7.5
CLP 7.4
LBP protein 7.2
Ses2 7.1
KAT4 7.1
PMSA2 7.1
Transmembrane protein 106A 7.1
PP6R2 7.1
homeobox D9 7.1
interferon-induced protein with tetratricopeptide repeats 5 7.1
GXIIB 7.1
TREM-1 6.9
triggering receptor expressed on myeloid cells 1 6.8
LPAAT-alpha 6.7
PELI3 6.7
complement factor H-related protein 4 6.7
P22PHOX 6.7
GSD1b 6.7
SUMF2 6.7
Cyclophilin J 6.7
proteasome subunit C3 6.7
MCG18 6.7
ARHGEF10L 6.7
CDH16 6.7
G protein-coupled receptor 109A 6.6
COH1 6.6
C5L2 6.6
TLT-1 6.5
cold-inducible RNA-binding protein 6.5
SAPS3 6.5
PVRIG 6.5
G5A 6.5
Granzyme K 6.5
G-protein coupled receptor 15 6.5
GTPBP4 6.5
Parotid secretory protein 6.5
TMEM219 6.5
endothelial protein C receptor 6.4
DNAJB12 6.3
vacuolar protein sorting 33B 6.3
COBP 6.3
E1A-associated protein p300 6.3
WDR82 6.3
TPCN1 6.3
NRG-4 6.3
FBXO15 6.3
MYLK3 6.3
CENPN 6.3
ATP-binding cassette sub-family A member 3 6.3
TRIM40 6.3
ADCY4 6.3
CD14 molecule 6.2
High-mobility group box 1 6.2
endocan 6.2
SORBS2 6.2
RIFLE 6.1
Bactericidal/permeability-increasing protein 6.1
myeloid differentiation primary response gene 6.1
LPS-binding protein 6.1
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Disease
Noninfectious myocarditis 9.1
Digital vasculitis 9.1
Crystal synovitis 9.1
Cowper's gland abscess 9.1
Sepsis with acute organ dysfunction 9.1
Generalized pustular psoriasis of pregnancy 9.1
Alternative pathway deficiency 9.1
Hypogammaglobulinemic sprue 9.1
Necrotizing esophagitis 9.1
Pseudosepsis 9.1
Diffuse crescentic glomerulonephritis 9.1
sepsis 9.1
Corynebacterium sepsis 9.1
Infantile pustular psoriasis 9.1
AIDS with histoplasmosis 9.1
Low output heart failure 9.1
Staphylococcal scarlatina 9.1
Myocardial decompensation 9.1
Congenital sepsis 9.1
Prostate infection 9.1
Arterial-enteric fistula 9.1
Meyer-Betz disease 9.1
Meningococcal bacteraemia 9.1
Cutaneous listeriosis 9.1
Acute left-sided heart failure 9.1
Gastrointestinal necrosis 9.1
Clostridium difficile septicemia 9.1
Iatrogenic hypothyroidism 9.1
Cholangitis lenta 9.1
Acute pyonephrosis 9.1
Late onset neonatal sepsis 9.1
Suppurative phlebitis 9.1
Hyperdynamic septic shock 9.1
cold injury syndrome 9.1
Boston exanthem 9.1
Anaerobic septicaemia 9.1
sepsis 9.1
Severe sepsis 8.8
Neonatal sepsis 8.8
Sepsis-associated encephalopathy 8.7
Serratia septicemia 8.7
Bacterial sepsis 8.5
Neutropenic sepsis 8.5
Gram positive sepsis 8.5
Enterococcal sepsis 8.5
Colonic gangrene 8.5
Salmonella paratyphi infection 8.5
Abdominal sepsis 8.5
Wound sepsis 8.3
Overwhelming post-splenectomy infection 8.3
Critical illness polyneuropathy 8.2
Septicemic melioidosis 8.2
Pneumococcal sepsis 8.1
unable to stop drinking 8.1
Cholestasis and jaundice 8.1
Pulmonary sepsis 8.1
Pulmonitis 8.1
Neonatal gangrene 8.1
Familial visceral neuropathy 8.1
Polymorphonuclear leukocytosis 8.1
Acute appendicitis with perforation 8.1
Scrotal abscess 8.1
stenosing cholangitis 8.1
Aortic valve vegetations 8.1
Rhinocerebral phycomycosis 8.1
perioophoritis 8.1
Listeria sepsis 8.1
mixed parotid tumour 8.1
Pyocystis 8.1
Staphylococcal mediastinitis 8.1
Pulmonary microemboli 8.1
Enterobacter sepsis 8.1
Algid malaria 8.1
Septic necrosis 8.1
gallbladder gangrene 8.1
Listeria septicemia 8.1
Corynebacterium jeikeium sepsis 8.1
Early onset neonatal sepsis 8.1
Lactobacillus infection 8.1
Salmonella pneumonia 8.1
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Symptom
Abdominal and pelvic pain 8.1
Antabuse effect 8.1
Varicophlebitis 7.5
decreased bowel sounds 7.2
Neuromuscular weakness 6.9
Organ failure 6.5
Generalized fatigue 6.5
Intermittent fever 6.4
Persistent vomiting 6.4
Pre-existing disease 6.3
Rebound tenderness 6.3
CVA tenderness 6.3
clammy skin 6.3
Frequency of defecation 6.2
joint symptom 5.7
Chills and fever 5.7
Incisional pain 5.7
swollen penis 5.7
Brudzinski's sign 5.6
oliguria 5.5
unable to breastfeed 5.5
Roth spots 5.4
Osler's nodes 5.4
respiratory distress 5.3
penile discharge 5.2
Murphy's sign 5.1
Sensory ataxia 5.0
Breast tenderness 5.0
Wound pain 5.0
Limb weakness 4.9
Cutaneous anergy 4.7
tachypnea 4.7
fever of unknown origin 4.6
inanition 4.6
pneumaturia 4.5
vasovagal attacks 4.4
rigors 4.4
anal pain 4.3
Howship-Romberg sign 4.3
PUO 4.3
thoracic back pain 4.3
chills 4.3
Postoperative vomiting 4.2
Mild pain 4.2
abnormal taste 4.2
right lower quadrant pain 4.1
localized erythema 4.1
GI irritation 4.1
acute abdomen 4.1
Abdominal tenderness 4.1
abdominal rigidity 4.1
left upper quadrant pain 4.0
pubic pain 4.0
swollen scrotum 4.0
lethargy 4.0
respiratory problem 4.0
S3 gallop 4.0
strangury 4.0
intestinal angina 4.0
cardiovascular impairment 3.9
localized abdominal pain 3.9
hepatosplenomegaly 3.9
prostration 3.8
neck stiffness 3.8
hypoproteinemia 3.8
cachexia 3.8
sinus congestion 3.7
right upper quadrant pain 3.7
sore throat 3.7
microbial colonization 3.6
loin pain 3.5
dark urine 3.5
Swallowing problems 3.5
adenitis 3.5
generalized rash 3.5
thigh pain 3.5
meningism 3.5
generalized abdominal pain 3.5
Reticulocytosis 3.5
Kernig's sign 3.5
more...
Drug
Viccillin 9.1
Sisomicin sulfate 9.1
Lidorestat 9.1
Indomethacin sodium 9.1
Drotrecogin alfa 8.7
Drotrecogin alfa 8.7
Thrombomodulin alfa 8.1
Aurexis 8.1
Benserazide hydrochloride 8.1
K506 8.1
Tifacogin 8.1
Sanfetrinem cilexetil 8.1
ThG 8.1
Centoxin 7.9
Glyceol 7.5
E5564 7.2
CZOP 7.0
CEPR 6.7
Habekacin 6.7
Sulfamylon 6.7
Minalrestat 6.5
Molgramostim 6.5
CFPM 6.3
Netilmicin sulfate 6.3
Ulinastatin 6.1
PAPM/BP 6.1
Silvadene 6.1
Rocephin 6.1
Sivelestat 6.1
Methenamine hippurate 6.1
Zenarestat 6.1
Tygacil 6.1
Mustargen 5.9
Chrysalin 5.9
Eniluracil 5.9
Sodium fusidate 5.9
Eniluracil 5.9
Lisofylline 5.9
Ranirestat 5.9
CZON 5.8
Lexipafant 5.7
Padimate O 5.7
Timentin 5.7
Edatrexate 5.7
Nafamostat mesilate 5.7
fluphenazine dihydrochloride 5.6
Hemocoagulase 5.6
Travase 5.6
Panipenem 5.6
Amikin 5.5
Sivelestat sodium hydrate 5.5
Dalacin 5.5
Micronomicin sulfate 5.4
Cefmenoxime 5.3
Tirilazad mesylate 5.3
Tobramycin sulfate 5.3
PZFX 5.3
CTRX 5.2
Piperacillin 5.2
Tirilazad mesylate 5.2
Dalfopristin 5.2
CEZ 5.1
MEPM 5.1
Dopexamine 5.1
CDZM 5.1
Alrestatin 5.1
FMOX 5.1
Claforan 5.0
SBT 5.0
Augmentin 5.0
Ethanolamine oleate 5.0
Argininosuccinate 5.0
CXM 4.9
Hydroxyethylstarch 4.9
Augmentin 4.9
Collodion 4.9
CZX 4.9
CMZ 4.8
Ambisome 4.8
Gabexate mesilate 4.8
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Enzyme
3-hydroxypropionate dehydrogenase 8.1
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 7.1
caspase-11 6.1
caspase-11 6.1
ubiquityl-calmodulin synthetase 6.1
C5a peptidase 5.6
phosphoenolpyruvate-protein phosphotransferase 5.6
acyloxyacyl hydrolase 5.3
AIR synthetase 5.3
granzyme K 5.2
ScpA 5.1
D-dopachrome tautomerase 5.0
thrombin-activatable fibrinolysis inhibitor 4.9
caspase-4 4.8
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase 4.8
5-oxoprolinase 4.6
caspase-4 4.6
EC 2.6.1.4 4.5
APC 4.5
ComC 4.4
caspase-5 4.4
fragilysin 4.4
granzyme M 4.2
peptidylarginine deiminase 4.2
caspase-5 4.1
methylmalonate-semialdehyde dehydrogenase 4.1
aspartate semialdehyde dehydrogenase 4.0
PPH 3.9
selenocysteine lyase 3.9
allophanate hydrolase 3.9
nicotinic acid phosphoribosyltransferase 3.9
carnosine synthetase 3.9
LuxS 3.9
carboxypeptidase II 3.8
coagulation factor XIa 3.8
phosphoamidase 3.8
mannosylphosphoryldolichol synthase 3.8
endo-N 3.8
inositol polyphosphate kinase 3.6
STK4 3.6
staphopain 3.6
neutrophil elastase 3.6
NAAT 3.6
cholesterol 25-hydroxylase 3.6
caspase-1 3.6
neurolysin 3.5
aureolysin 3.5
MIP 3.5
S-adenosylhomocysteine nucleosidase 3.4
meprin 3.4
acylglycerol kinase 3.4
sphingomyelinase D 3.3
FTR 3.3
Hageman factor 3.2
CMP-Neu5Ac synthetase 3.2
NO synthase 3.2
NOS 3.1
nicotinamide phosphoribosyltransferase 3.1
IgA protease 3.1
elastase 3.1
sulfiredoxin 3.1
cathepsin V 3.1
factor D 3.1
neutrophil collagenase 3.1
lysophosphatidylcholine acyltransferase 3.0
N-acetylglucosamine deacetylase 3.0
GRK5 3.0
C1 esterase 3.0
thromboplastin 3.0
GAS 3.0
thrombin 3.0
BMT 2.9
beta-lactamase 2.9
thromboxane synthase 2.9
serralysin 2.9
exonuclease VII 2.9
kallikrein 2.9
heme oxygenase 2.9
LipA 2.9
lysin 2.8
more...
Compound
Thalazole 9.1
Aspartyl-L-proline 8.1
Fluopsin C 8.1
3,5-dichloro-4-hydroxybenzoic acid 8.1
Lacto-N-difucohexaose 7.5
2-methyl-6-undecylpiperidine 7.1
Murrayanine 7.1
Cefozopran 6.7
Ticarcillin disodium 6.7
Ethyl pyruvate 6.6
Sulfamylon 6.6
2-thiophenesulfonamide 6.5
Dimethyl itaconate 6.5
Tamarixetin 6.5
Gracillin 6.3
Dihydrofisetin 6.3
Caracemide 6.3
6-hydroxynorleucine 6.3
Nepodin 6.3
6-hydroxynorleucine 6.3
6-hydroxynorleucine 6.3
Cefazolin sodium 6.1
1-pyrrolidinecarbodithioic acid 6.1
Cefotaxime sodium 6.1
2,5-piperazinedione 5.9
Isocarboxazide 5.9
Complement factor B 5.9
Tabersonine 5.9
[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 5.9
3-Methylxanthine 5.9
3-T1 5.8
N-benzoyl-beta-alanine 5.7
Tubeimoside I 5.7
ethanimidamide 5.7
Senegenin 5.7
Sinomenine hydrochloride 5.7
2-hydroxyhexadecanoic acid 5.7
HM-4 5.6
Micheliolide 5.5
Micheliolide 5.5
Resolvin D2 5.5
2-(cyclohexylamino)ethanesulfonic acid 5.5
3 PS 5.5
Ceforanide 5.5
Staphyloxanthin 5.5
Piperacillin sodium 5.5
Phenyllactate 5.5
Cosyntropin 5.5
Etiocholanolone 5.4
Allysine 5.4
Aspoxicillin 5.4
Nocardicin A 5.4
Aerobactin 5.4
2,5-dimethoxytetrahydrofuran 5.3
Cinnamamide 5.3
Palmitoyl-L-carnitine 5.3
Hepoxilin A3 5.3
Piperacillin 5.2
Mezlocillin 5.2
ET-15 5.2
AFU 5.2
3-methylhistidine 5.2
Dalfopristin 5.2
Zingerone 5.1
Aloin 5.1
Aztreonam 5.1
Ammonium pyrrolidine dithiocarbamate 5.1
3,5-dibromo-4-hydroxybenzoic acid 5.1
trans-Stilbene 5.1
Cefmetazole 5.0
Pentoxifylline 5.0
Man9(GlcNAc)2 5.0
36L 5.0
Cefotetan 5.0
Imipenem 4.9
DIC 4.9
Deoxyelephantopin 4.9
Metocurine 4.9
Amikacin 4.9
Moxalactam 4.9
more...