Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 3707
cytokine 3141
lipopolysaccharide 3117
IL-6 1722
LPS 1687
tumor necrosis factor 1620
TNF 1547
Pseudomonas 1500
Mol 1325
IL-10 907
gut 900
C-reactive protein 878
TLR4 824
She 791
TNF-alpha 727
interleukin-6 654
insulin 597
inducible nitric oxide synthase 558
IL-8 545
albumin 544
thrombin 494
myeloperoxidase 431
nitric oxide synthase 430
fibrinogen 395
tumor necrosis factor alpha 386
IL-1 383
interferon 376
hemoglobin 376
granulocyte 370
CD4 349
CD14 340
protein C 338
IFN 337
caspase-3 315
tissue factor 302
chemokine 300
Cytokine 294
p38 290
ATP 289
TLR2 271
prothrombin 267
CSF 258
lymphoid 258
serum albumin 238
glycoprotein 237
superoxide dismutase 233
antithrombin 233
p65 220
MIC 209
CRP 207
MRI 205
collagen 202
granulocyte colony-stimulating factor 200
chronic renal failure 200
interleukin 6 195
CD11b 194
fibronectin 194
MAPK 192
vascular endothelium 186
CD8 185
IFN-gamma 183
thromboplastin 181
high mobility group box 1 181
catalase 179
IgA 177
MyD88 175
HLA 171
Tumor necrosis factor 167
muscle protein 167
thrombomodulin 166
alanine aminotransferase 166
CLP 165
alkaline phosphatase 164
aspartate aminotransferase 163
IL-1 beta 162
vasopressin 159
antithrombin III 158
Bcl-2 158
interferon-gamma 155
IL-2 150
interleukin-10 147
IL-18 146
H. influenzae 145
IL-4 145
ICAM-1 144
lactate dehydrogenase 139
DIC 138
THP 137
HMGB1 135
MCP-1 133
ubiquitin 133
HLA-DR 131
reserved 130
lactoferrin 130
histone 128
proteasome 128
IL-17 126
JNK 124
MRSA 123
heme oxygenase-1 123
Pol 122
ERK 122
ERK1 122
SARS 118
adhesion molecule 116
cyclooxygenase 116
G-CSF 114
NLRP3 113
transferrin 113
GBS 110
thymus 109
GSH 104
plasminogen activator inhibitor-1 104
membrane protein 103
PLA 102
non-Hodgkin's lymphoma 102
glucagon 102
PI3K 101
MIP 101
ferritin 100
ROS 99
kit 98
endoplasmic reticulum 95
growth hormone 93
glucan 93
bradykinin 93
mTOR 92
calcitonin 90
white cell 89
plasminogen activator inhibitor 89
LDH 89
CD64 88
STAT3 88
E-selectin 88
renin 88
TOF 88
E. coli) 88
serine protease 87
galactosamine 87
creatine kinase 86
polypeptide 86
tissue factor pathway inhibitor 86
Protein C 85
macrophage migration inhibitory factor 85
COX-2 84
vascular cell adhesion molecule-1 84
SOD 84
CD18 82
CO2 82
plasminogen 81
interleukin-2 80
von Willebrand factor 78
natriuretic peptide 78
cyclooxygenase-2 78
AML 78
TLR9 76
CD25 76
granulocyte-macrophage colony-stimulating factor 75
ACTH 75
C5a receptor 75
more...
Disease
sepsis 59461
sepsis 52184
pneumonia 3849
cancer 2771
meningitis 2545
bacteremia 1956
infectious diseases 1579
peritonitis 1511
diabetes 1370
disseminated intravascular coagulation 1228
endocarditis 1081
Infection 1080
tumor 1046
ischemia 1041
renal failure 1034
neutropenia 979
bacterial infection 975
Klebsiella 931
thrombocytopenia 903
acute renal failure 845
heart failure 799
respiratory failure 769
adult respiratory distress syndrome 751
urinary tract infection 732
stroke 701
hypertension 695
anemia 678
cirrhosis 595
coagulopathy 591
necrotizing enterocolitis 581
osteomyelitis 565
depression 559
pancreatitis 551
leukemia 518
HIV 513
malnutrition 508
arthritis 507
liver disease 488
encephalopathy 466
renal disease 465
immunodeficiency 458
lymphoma 455
myocardial infarction 441
carcinoma 420
cellulitis 407
acute pancreatitis 407
rheumatoid arthritis 399
AIDS 397
Haemophilus 392
tuberculosis 392
pulmonary edema 391
Infections 390
prematurity 383
abortion 377
acute myeloid leukemia 370
hepatitis 353
rash 340
leukopenia 338
cholangitis 336
septic arthritis 323
gastroenteritis 323
pulmonary embolism 321
cytomegalovirus 314
pyelonephritis 309
congestive heart failure 306
systemic lupus erythematosus 306
Severe sepsis 305
Crohn's disease 304
pulmonary hypertension 300
hypoglycemia 294
chronic renal failure 294
fasciitis 294
obesity 293
atherosclerosis 291
virus infection 285
cholestasis 285
heart disease 282
influenza 282
fungal infection 280
malaria 279
coma 275
dehydration 274
vasculitis 273
graft-versus-host disease 273
bowel obstruction 270
hyperglycemia 269
chorioamnionitis 263
asthma 262
metastases 257
cardiomyopathy 256
SIRS 255
bacterial meningitis 253
empyema 252
gangrene 249
hernia 240
endotoxic shock 239
inflammatory bowel disease 239
nosocomial infection 238
ARF 229
agranulocytosis 225
toxic shock syndrome 223
colitis 219
enterocolitis 219
candidiasis 217
acute lymphoblastic leukemia 215
melioidosis 211
hyperbilirubinemia 206
lung disease 205
chronic obstructive pulmonary disease 201
thrombophlebitis 197
purpura 197
bronchopulmonary dysplasia 196
cardiovascular disease 193
Hodgkin's disease 192
pancytopenia 192
myelosuppression 192
mediastinitis 191
acute leukemia 190
pneumothorax 190
preeclampsia 188
cystic fibrosis 188
renal insufficiency 185
encephalitis 183
ulcerative colitis 180
sickle cell disease 179
ileus 177
gallstones 175
myocarditis 175
Yersinia 175
cold 173
acute myocardial infarction 172
cholecystitis 171
Neonatal sepsis 171
uterus 170
enteritis 168
Mycobacterium 166
Proteus 165
MRSA 165
appendicitis 165
listeriosis 163
staphylococcus 163
adenocarcinoma 162
deep vein thrombosis 161
SARS 159
multiple myeloma 159
lymphadenopathy 158
liver abscess 157
West 156
muscular atrophy 155
otitis media 155
lactic acidosis 154
adrenal insufficiency 152
bronchopneumonia 152
meningoencephalitis 149
glomerulonephritis 148
myocardial ischemia 147
eclampsia 146
alcoholism 141
premature rupture of membranes 140
cognitive impairment 138
more...
Symptom
respiratory distress 1450
diarrhea 1008
pain 964
anesthesia 644
abdominal pain 505
vomiting 481
hypothermia 314
weakness 307
seizures 306
nausea 223
dyspnea 212
collapse 208
fatigue 175
lethargy 171
headache 163
splenomegaly 159
anorexia 158
oliguria 157
chills 152
cachexia 144
starvation 130
hepatosplenomegaly 122
tachypnea 120
cough 113
nausea and vomiting 112
Ill 108
erythema 106
hepatomegaly 103
analgesia 99
acute abdomen 99
fever of unknown origin 95
discomfort 83
discomfort 82
back pain 78
chest pain 75
exhaustion 67
sore throat 66
cyanosis 62
hemoptysis 60
constipation 59
colic 55
myalgia 54
arthralgia 53
regurgitation 52
hypercapnia 50
hyperoxia 47
shortness of breath 44
hypotonia 44
sleepiness 37
angina 37
flank pain 36
functional recovery 36
syncope 34
pallor 34
rigors 32
paresis 31
epigastric pain 31
low back pain 30
acute abdominal pain 29
hypoproteinemia 29
ataxia 27
polyuria 26
flushing 26
ENT 26
neck pain 25
dysuria 25
microbial colonization 24
hip pain 23
pelvic pain 22
productive cough 22
bone pain 22
tremor 21
dizziness 21
agitation 21
acidity 20
asthenia 19
overweight 18
abdominal discomfort 18
spasticity 18
right upper quadrant pain 17
acute stress 17
neck stiffness 16
spasm 16
tense 15
blurred vision 15
Wind 14
stridor 14
distraction 14
hemiplegia 14
intestinal bleeding 14
thigh pain 14
rhinorrhea 13
knee pain 13
twitching 13
paraparesis 13
hoarseness 13
dysarthria 13
emaciation 13
leg pain 13
muscle rigidity 13
consciousness disturbance 13
wheezing 12
chronic cough 12
renal colic 12
adenitis 12
hypocapnia 11
numbness 11
paresthesia 11
nasal discharge 11
Organ failure 11
livedo 11
HSA 11
prostration 10
right lower quadrant pain 10
tonic-clonic seizure 10
inanition 10
exertional dyspnea 10
shoulder pain 10
myoclonus 10
ophthalmoplegia 9
thinning 9
anal pain 9
chronic constipation 8
decreased appetite 8
hypertonia 8
rales 7
loin pain 7
polydipsia 7
ketonuria 7
apathy 7
meningism 7
acute pain 7
night sweats 6
retching 6
tinnitus 6
insomnia 6
autodigestion 6
pneumaturia 6
pleuritic chest pain 6
neurological disability 6
skin irritation 6
otalgia 6
bloating 6
dark urine 6
skin damage 6
cerebellar ataxia 5
torticollis 5
photophobia 5
facial pain 5
cancer pain 4
nipple discharge 4
physical appearance 4
leg edema 4
vertigo 4
presyncope 4
loss of balance 4
stigma 4
nipple discharge 4
dystonia 4
urinary frequency 4
more...
Drug
ampicillin 529
Cardiovasc 406
CSF 308
Dermatol 260
IFN-gamma 180
IL-2 150
Dial 144
Monit 123
G-CSF 116
lysine 106
Nephron 103
ROS 99
ascorbate 93
CTX 92
ROC 92
IPM 74
CTX 74
CTX 73
MAP 69
Drotrecogin alfa 62
Drotrecogin alfa 62
Nephron 55
Albumin 53
Bifidobacterium 47
MOF 44
Ceftazidime 43
Heme 42
lactose 41
vitamin E 39
NADH 38
ENT 36
Piperacillin 35
IL-1ra 35
Ringer's solution 33
Portal 33
Indomethacin 30
Meropenem 29
Adriamycin 29
Antithrombin III 28
p75 27
AZT 26
Simvastatin 25
SBT 24
TAK 24
Gel 23
Meropenem 23
Rituximab 23
Fluconazole 22
AMC 21
Propofol 21
Colistin 20
Fraction 20
Amoxicillin 19
caffeine 19
Nitric Oxide 19
Serum albumin 19
nitroglycerin 19
CPR 19
TAT 19
Leaf 17
Augmentin 16
CPZ 16
Methylprednisolone 16
Taxol 16
Asthma 16
Augmentin 16
Prednisolone 16
Cimetidine 15
Cimetidine 15
Ulinastatin 15
Tacrolimus 14
Growth hormone 14
Ethanol 14
Growth hormone 14
Zinat 14
Levosimendan 13
MDS 13
DNase I 13
Spectrum 12
Fluorescein 12
Aminoguanidine 12
Glutathione 12
ABC 12
CPT-11 12
Ofloxacin 11
uPA 11
Hypaque 11
Alliance 11
IFN-beta 11
Filgrastim 11
ADM 10
Glucagon 10
Campath 10
Parkin 10
citric acid 10
E5564 10
Parkin 10
Histamine 10
Campath 10
Dakar 10
ARA-C 10
Trimethoprim-sulfamethoxazole 10
Docetaxel 10
Filgrastim 10
AmBisome 9
Fructose 9
Rocephin 9
Emodin 9
Sulfamylon 9
Ganciclovir 9
Alanine 9
CaCl2 9
CTRX 9
Doxycycline 9
Diphenhydramine 9
Methylene blue 9
ALA 8
Ketoconazole 8
Infliximab 8
ETA 8
EPA 8
Mezlocillin 8
CAZ 8
Infliximab 8
Vinorelbine 8
CTM 8
PAPM/BP 8
ICI 8
Lovastatin 8
Angiotensin II 8
IL-11 7
PTH 7
Emodin 7
Vena 7
Vitamin A 7
Etoposide 7
CaCl2 7
Prednisone 7
CaCl2 7
Aprotinin 7
Vena 7
PTC 7
Itraconazole 7
Misoprostol 7
Phosphatidylserine 7
CCL 7
Caspofungin 7
Pefloxacin 7
THA 7
Acyclovir 7
MRC 7
Timentin 7
Survanta 7
Spectrum 7
CDP 7
DEX 7
Moxifloxacin 7
CAM 7
HCG 6
Amiloride 6
more...
Enzyme
APC 683
mitogen-activated protein kinase 521
peroxidase 483
thrombin 483
alanine aminotransferase 354
superoxide dismutase 289
NO synthase 263
aspartate aminotransferase 238
caspase-3 226
ERK 201
catalase 200
thromboplastin 197
beta-lactamase 191
protein kinase 170
lactate dehydrogenase 169
alkaline phosphatase 164
elastase 146
focal adhesion kinase 141
caspase-1 139
proteasome 137
protein kinase C 123
NOS 118
creatine kinase 112
luciferase 108
NADPH oxidase 102
MIP 101
plasmin 97
NADPH oxidase 94
neutrophil elastase 93
renin 88
phospholipase A2 86
tissue plasminogen activator 85
kallikrein 84
AMP-activated protein kinase 77
ATPase 74
lysozyme 74
glutathione peroxidase 70
AST 69
reverse transcriptase 67
MAP 66
phosphodiesterase 63
urokinase-type plasminogen activator 61
neuraminidase 57
heme oxygenase 57
ACS 57
trypsin 56
phospholipase C 55
ACE 55
IKK 52
lipase 51
xanthine oxidase 48
collagenase 48
guanylate cyclase 47
caspase-11 46
complex I 46
caspase-11 46
PARP 43
phosphatidylinositol 3-kinase 42
RNA polymerase 41
BMT 38
calcineurin 38
AMPK 38
caspase-8 37
AMPK 35
pyruvate dehydrogenase 34
MEK 33
DNase 33
acetylcholinesterase 32
CD10 31
caspase-9 30
transcriptase 30
succinate dehydrogenase 29
cytochrome oxidase 28
asparaginase 28
lipoxygenase 27
GSK 27
gamma-glutamyl transpeptidase 27
phosphoinositide 3-kinase 26
RNase 24
glucose-6-phosphate dehydrogenase 24
cathepsin G 24
myosin light chain kinase 23
RNase 22
lipoprotein lipase 22
CPR 21
PDK1 20
arginase 20
cholinesterase 20
adenylate cyclase 20
cathepsin B 19
urease 19
TAT 19
urease 19
pyruvate dehydrogenase 19
CPT 19
pyruvate dehydrogenase 19
caspase-4 19
caspase-4 19
hyaluronidase 18
ceruloplasmin 18
glutaminase 17
hyaluronidase 17
matrix metalloproteinase 9 17
GRK5 17
glutamine synthetase 16
sialidase 16
BAL 15
deoxyribonuclease 15
PKG 15
thrombin-activatable fibrinolysis inhibitor 14
deoxyribonuclease 14
prostate-specific antigen 14
endonuclease 14
topoisomerase 14
diamine oxidase 14
GAS 14
lysin 14
adenosine deaminase 13
adenosine deaminase 13
beta-glucuronidase 13
glutathione S-transferase 13
topoisomerase 13
phosphoenolpyruvate carboxykinase 12
indoleamine 2,3-dioxygenase 12
acid phosphatase 12
glyceraldehyde-3-phosphate dehydrogenase 12
p100 12
peptidylarginine deiminase 12
phosphoenolpyruvate carboxykinase 11
phosphoenolpyruvate carboxykinase 11
granzyme B 11
arginine deiminase 11
MDR 11
meprin 11
ScpA 11
citrate synthase 11
P-glycoprotein 10
ornithine transcarbamylase 10
ornithine decarboxylase 10
CD13 10
angiotensin-converting enzyme 2 10
glutamate dehydrogenase 10
chymotrypsin 10
glutamate dehydrogenase 10
glutamate dehydrogenase 10
Hageman factor 9
pyruvate kinase 9
ATP synthase 9
glyceraldehyde-3-phosphate dehydrogenase 9
CPT 9
peroxiredoxin 9
enolase 9
NQO1 9
CPT 9
C3 convertase 9
C3 convertase 9
phosphorylase 8
aldehyde dehydrogenase 8
pepsin 8
glyceraldehyde-3-phosphate dehydrogenase 8
more...
Compound
Clin 5036
Dec 3931
oxygen 2108
TNF 1547
DNA 1269
nitric oxide 1194
glucose 1013
creatinine 950
water 903
sodium 640
calcium 627
nitrogen 582
urea 480
arginine 438
iron 433
His 371
phosphate 336
Cardiol 322
ATP 289
CO2 254
glutamine 247
tyrosine 227
galactose 223
sulfate 221
MIC 209
leucine 204
nitrate 199
acetate 195
potassium 184
hydrogen 173
alanine 172
Phe 171
zinc 164
serine 158
DIC 151
lysine 146
Dial 144
THP 137
cysteine 137
THP 137
ethanol 132
Methicillin 132
Parenteral 123
silver 120
prostacyclin 116
GSH 113
GSH 113
Vancomycin 109
iodine 107
cAMP 107
Optimal 104
salt 94
CTX 92
noradrenaline 89
TOF 88
ADP 85
methionine 85
PGE2 85
PEG 83
Insulin 82
ammonia 80
NADP 78
vitamin D 78
Lactate 75
N-acetylcysteine 74
cGMP 74
glutamate 72
ACTH 71
Ile 71
barium 71
ADP 70
GPT 70
Penicillin 69
SDS 69
tryptophan 68
tryptophan 68
MAP 68
ADP 67
tryptophan 66
threonine 66
tryptophan 66
valine 65
glycerol 64
PEG 63
Glutamine 63
H2S 63
NAD 62
Gentamicin 62
Melatonin 61
copper 60
BRL 59
ACS 57
ACS 57
Penicillin 57
H2O2 57
selenium 55
EDTA 55
Imipenem 53
PGE 53
nicotinamide 53
TEM 53
3-methylhistidine 53
EDTA 53
phosphorus 52
neopterin 52
Guo 52
Guo 51
Thrombin 50
aldosterone 50
Heparin 49
isoleucine 49
Pentoxifylline 49
proline 49
isoleucine 48
AMP 47
A 3 46
Heme 45
Asp 45
dUTP 45
ASA 45
VP-16 44
Norepinephrine 43
NH2 43
5-FU 43
Ceftazidime 43
Ciprofloxacin 43
sodium chloride 43
NAD 42
ammonium 42
Amphotericin B 42
Amikacin 41
MTT 41
MDA 40
BCG 40
Adriamycin 39
Gly 39
Ceftriaxone 38
Dexamethasone 38
NADH 38
Ascorbic acid 38
FK506 38
Hematoxylin 37
Hemoglobin 37
NIDA 37
DMSO 36
GMP 36
CAM 35
NO3 35
Piperacillin 35
6-12 34
Isoproterenol 34
CAT 34
phenol 34
A 1 34
carbonate 34
PMA 34
Adrenal 34
prostaglandin E1 33
superoxide radical 33
A 71 33
more...