Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases are presented and analyzed in which a Lippman Transfixion Hip Prosthesis had to be replaced because of the discomfort of the patient. In each case, there was evidence of wear between the head of the prosthesis and the flange. The different wear patterns indicated problems which exist in the alignment of component parts of the prosthesis. In each case there was low grade sepsis to which the debris may have contributed. Because of phagocytosis, amount of debris accumulation was difficult to evaluate. The factors which appear to have contributed to the amount of debris accumulation were: the length of time the prosthesis had been used; the degree of alignment and amount of debris which may be formed and is phagocytized; the degree of manufacturing control. The design of this prosthesis incorporated mechanical problems which are generally undesirable because of: the eventual deformation of the end of the pivot rod or hole in the head of the prosthesis: progressive loosening of the movement due to this and inherent malalignment; the difficulty in fabrication, assembly and installation of the prosthesis because of the multiplicity of parts; the difficulty in maintaining adequate control of surface finishes.
 ...
PMID:Biomechanical considerations of multiple-component hip prostheses. Analysis of three failures of the Lippman transfixation hip prosthesis. 112 66

Because of the continuing hazard of post-operative sepsis in joint replacement surgery and the possibility that persistent bone ischemia may be a contributing factor, it is desirable to know the hemodynamic consequences in bone of the implantation of orthopedic acrylic cement. Experiments were carried out on 60 rats. In 30, a bore-hole was made, unilaterally, in the tibia. In another 30, a bore-hole was made in the tibia and a small amount of polymethylmethacrylate cement (Surgical Simplex P) was implanted into the marrow cavity through the bore-hole. By means of 51-Cr labeled red cells and 59-Fe labeled resin particles, the blood volume and blood flow rate in the tibiae were calculated simultaneously as a percentage of the values in the contralateral tibiae. The results showed that at 14 days and 112 days postoperatively, both blood volume and flow were significantly depressed in tibiae in which acrylic cement had been implanted, as compared with tibiae in which only a bore-hole had been made. It was concluded that orthopedic cement implanted into bone renders the bone hypovascular.
 ...
PMID:Circulatory depression in bone after acrylic implantation. 113 83

One hundred cases of brain abscess presenting between 1974 and 1984 are reviewed. The overall mortality was 20%, 98 cases were actively treated with a peroperative mortality of 14%. The results are compared to Garfield's 1969 series, drawn from similar clinical material. Changes in presentation and outcome are described. A significant improvement in survival (p less than 0.001) has occurred following the introduction of computerised tomography (CT Scan) which permits the rapid diagnosis and accurate localisation of intracranial sepsis. As the basic therapeutic regime remains unchanged (burr hole aspiration and appropriate antibiotic treatment), other aspects of management have been examined, leading to the suggestion that CT Scanning has made a major contribution to the reduction in mortality.
 ...
PMID:CT scanning in the management of intracranial abscess: a review of 100 cases. 326 27

A serious septicemia developed in a patient two years after placement of a Dacron mesorenal shung for bleeding esophageal varices. The source of the sepsis remained unknown for 13 months and was refractory to antibiotic therapy. Roentgenographic studies showed the shunt to be patent and without intralumenal thrombus. At operation, the shung was being contaminated by a hole in the proximal jejunum and the patient has been cured of sepsis by removing the shunt. In contrast to the presentation of infected prosthesis used in the arterial system, infectious complications of prosthesis used in the portal systemic venous system occur without thrombosis of the shunt, aneurysm formation, or intraintestinal bleeding thus making operative evaluation the only means of diagnosis.
 ...
PMID:Infected Dacron mesorenal portosystemic shunt. 644 69

Flexible Medullary Nailing is an excellent method in children when operative management is indicated. It is a new biomechanical concept using prebent flexible rods introduced in a metaphyseal area. In femoral shaft fractures, closed percutaneous nailing permits stabilization using wires inserted by a medial and a lateral approach. In severely displaced humeral fractures of the upper end, two Kirschner wires are inserted under X-ray control through a epicondyl hole. Pinning can be indicated in others fractures : tibia, radial neck (original procedure), fore arm, humeral supracondylar original procedure and shaft fractures. This closed surgical procedure can always be done; the complication rate is light (no sepsis, no delayed union). Early mobilisation is often possible and cast is not necessary.
 ...
PMID:[Closed flexible medullary nailing in pediatric traumatology]. 667 Dec 61

To provide a means of taking repeated blood samples from conscious, stress-free rats, we devised a method to chronically cannulate the inferior vena cava. The rat was anesthetized with pentobarbital sodium plus methoxyflurane. The inferior vena cava was exposed through a midline abdominal incision. Silastic tubing (0.020 in. ID, 0.037 in. OD) was pushed through a tiny hole punctured in the wall of the vein; it remained in place without leaking due to the elasticity of the vessel wall. The cannula was advanced towards the heart until its tip lay at the level of the xiphisternum at which point blood could be aspirated. A series of silk (4-0) sutures to the psoas muscle and body wall held the cannula secure without compromising blood flow. The cannula ran subcutaneously to the back of the neck where it was ligated to the underside of the skin (prolene 4-0 suture), plugged with a short metal obturator, and exteriorized through a small stab wound. The cannula was filled with heparinized saline, but it was not necessary to regularly flush it through to maintain patency. Sepsis did not occur and animals autopsied several months after cannulation showed no tissue reaction around the cannula.
 ...
PMID:Chronic, nonocclusive, and maintenance-free central venous cannula in the rat. 739 27

The characteristics of brain abscess in the Central Province of Saudi Arabia are outlined in this report which is a review of 22 consecutive cases that were treated at King Khalid University Hospital between 1985-1991. The incidence of brain abscess in Saudi Arabia is calculated to be 3.6 cases/500,000 population/year which is twice as high as the incidence reported from the West. There were 17 males and 5 females with an age range of 8 months-80 years (mean 29.9 years). The parietal lobe was involved in 27%, while the abscess was in the posterior fossa in 14% and multiple in another 14% of cases. The primary source of sepsis was unknown in 50%, post-traumatic in 18% and from a dental and mastoid origin in 14% of cases only. Duration of symptoms ranged between 4-30 days (mean 12 days). Fever was present in 55% of cases and epilepsy in 23%. Sixteen (73%) cases had burr hole aspiration, while 3 (14%) had craniotomy and excision, and 3 (14%) cases were managed with antimicrobial treatment only. Staphylococci were the pathogens in 27%, while streptococci were cultured in 23% cases and the culture was negative in 23%. Three (14%) cases all of which died had fungal abscesses caused by Fonsecaea pedrosoi. The mortality was 18%, good recovery in 68% and fair recovery in 14%. Follow-up was from 3 months to 5.5 years (mean 1.8 years).
 ...
PMID:Experience with brain abscess in the central province of Saudi Arabia. 794 Oct 5

Sinus-induced intracranial sepsis can represent a genuine medical and surgical emergency. We review 12 cases presenting to our hospitals over a five-year period. Nine were male and three were female with an age range of 16 to 74 years (mean 35.5 years). Four patients had their sinusitis diagnosed prior to admission and eight did not. Nine patients had bilateral sinus disease, the most common sinus involved was the frontal followed by the ethmoid, maxillary and sphenoid. Neurosurgical drainage was via a craniotomy in seven cases and burr hole in three. Nine patients underwent sinus surgery and three did not. Of the nine who had sinus surgery three had frontal drainage, four fronto-ethmoidal and two trans-sphenoidal drainage. The most common organism was Streptococcus milleri. Our series confirms that sinus-induced intracranial sepsis is a serious problem needing early diagnosis and aggressive treatment. We would recommend a high index of suspicion of sinusitis in patients with intracranial infection.
 ...
PMID:Intracranial complications of sinusitis: the need for aggressive management. 855 Nov 20

Sixty-seven patients with brain abscess were managed over 19 years (1975-1993). Our series had a 2.5 to 1 male predominance; the age distribution was from 3 days to 81 years. The underlying conditions of hematogenic brain abscesses (n = 33; 49%) included lung infections (n = 16), heart disease (n = 4), sepsis (n = 10), and other foci (n = 3). Otolaryngologic infections led to the abscess in 10 cases; there were 9 traumatic abscesses. The causes remained unknown in 15 cases. There were 47 solitary abscesses (70%) and 20 multiple abscesses. The most frequent presenting signs and symptoms were neurologic deficits (n = 17), disturbances of consciousness (n = 14), seizures (n = 6), and headaches, meningism and vomiting (n = 13). Causative organisms were isolated in 39 cases (58%) and included staphylococci (n = 6), streptococci (n = 6), enterobacteriae (n = 2), and anaerobic pathogens (n = 9). The most reliable laboratory sign of inflammation was an elevated ESR (52/59 patients). With the advent of computed tomography, burr hole aspiration of the abscess with or without drainage was possible in 30 cases; the mortality in this subgroup was 9%. All 4 patients with surgical excision in the pre CT-era died. The mortality of patients treated with antibiotics only was 62% (18/29). Overall mortality was 37% (25/67), including 5 cases with post mortem-diagnosis of brain abscess. Good recovery was achieved in 29/42 survivors. Predictors of a poor outcome were the patient's age, the level of consciousness, multiple abscesses, polybacterial cultures, and a hematogenic etiology, but not the size of the abscess.
 ...
PMID:[Bacterial brain abscess--experiences with 67 patients]. 880 80

External duodenal fistulae from sutured duodenal ulcer perforation sites are difficult to manage and most patients succumb to septicemia and undernutrition. This is due to failure of closure of the perforation site in the duodenum. Most techniques described in the past to facilitate closure have failed to give satisfactory results. We have devised a new procedure where the duodenal ulcer perforation is closed by mobilizing the gall bladder. A hole is made in the fundus of the gall bladder and it is anastomosed to the freshened edges of the duodenal opening. We have treated six patients by this technique. In five patients the leak was satisfactorily sealed. Three patients died - one due to persistent leak and two due to jejunostomy leak.
 ...
PMID:Cholecystoduodenoplasty for high-output duodenal fistula. 1181 91


1 2 3 Next >>