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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vulvovaginal infection is the most common cause of gynecological problems in sexually active women. Few years ago it was not considered as serious disease which may cause major health implications. Currently we are aware that it implies life worsening, temporal indisposition, postoperative complications and even life threatening sepsis in patients hospitalized in Intensive Care Units. Knowledge about pharmacological properties of drugs used in treatment vulvovaginal candidiasis allows for tailoring therapy to each patient. Fluconazole is modern and up to date option for treatment of VVC/rVVC. Short- and long-term therapeutic efficacy of fluconazole was confirmed in numerous high reliability clinical trials. Good tolerance, wide range of single therapeutic dose and high level of patient's acceptance gives the specialist powerful and efficient tool for management of VVC/rVVC.
Ginekol Pol 2008 Sep
PMID:[Treatment of acute and recurrent vulvovaginal candidiasis (VVC/rVVC)--state of art in 2008. Expert Board of Polish Gynecological Society]. 1893 17

The nosocomial infections caused by Gram-negative bacteria, in this number Acinetobacter baumannii and Pseudomonas aeruginosa, have severe course and relatively high prevalence of sepsis cases. Pathomechanism of sepsis is related to activation and release of bacterial endotoxin, which is a macromolecule engaged in initiation of cytokine cascade. These mediators are responsible for heavy tissues and organs devastation. Factors that bind and neutralize endotoxin in organism are promising candidates for experimental therapy of sepsis.
Pol Merkur Lekarski 2008 Sep
PMID:[Role of endotoxin in pathomechanism of sepsis]. 1911 45

Common variable immunodeficiency is a primary immunodeficiency disease, characterized by hypogammaglobulinemia, low serum immunoglobulin concentrations, and recurrent bacterial infections of the respiratory and gastrointestinal tracts. We report on a 33-year-old patient with suspected sarcoidosis, diagnosed on the basis of an open lung biopsy, who was admitted to the National Tuberculosis and Lung Diseases Research Institute because of severe pneumonia and streptococcal sepsis. During diagnostics based on typical, clinical and laboratory features, CVID was diagnosed. The antibiotic treatment was successfully administered and the patient was directed to supplementary treatment.
Pneumonol Alergol Pol 2009
PMID:[Common variable immunodeficiency in a patient with suspected sarcoidosis]. 2016 25

Potassium channels are the most widely distributed class of ion channels. These channels are transmembrane proteins known to play important roles in both normal and pathophysiological functions in all cell types. Various potassium channels are recognised as potential therapeutic targets in the treatment of Parkinson's disease, Alzheimer's disease, brain/spinal cord ischaemia and sepsis. In addition to their importance as therapeutic targets, certain potassium channels are known for their beneficial roles in anaesthesia, cardioprotection and neuroprotection. Some types of potassium channels present in the plasma membrane of various cells have been found in the inner mitochondrial membrane as well. Potassium channels have been proposed to regulate mitochondrial membrane potential, respiration, matrix volume and Ca(+) ion homeostasis. It has been proposed that mitochondrial potassium channels mediate ischaemic preconditioning in various tissues. However, the specificity of a pharmacological agents and the mechanisms underlying their effects on ischaemic preconditioning remain controversial. The following potassium channels from various tissues have been identified in the inner mitochondrial membrane: ATP-regulated (mitoK(ATP)) channel, large conductance Ca(2+)-regulated (mitoBK(Ca)) channel, intermediate conductance Ca(2+)-regulated (mitoIK(Ca)) channel, voltage-gated (mitoKv1.3 type) channel, and twin-pore domain (mitoTASK-3) channel. It has been shown that increased potassium flux into brain mitochondria induced by either the mitoK(ATP) channel or mitoBK(Ca) channel affects the beneficial effects on neuronal cell survival under pathological conditions. Recently, differential distribution of mitoBK(Ca) channels has been observed in neuronal mitochondria. These findings may suggest a neuroprotective role for the mitoBK(Ca) channel in specific brain structures. This minireview summarises current data on brain mitochondrial potassium channels and the efforts to identify their molecular correlates.
Acta Biochim Pol 2009
PMID:Potassium channels in brain mitochondria. 1975 22

The procalcitonin (PCT) is a sensitive and reliable biochemical marker used in diagnosing and monitoring of bacterial infections. The procalcitonin assay allows for effective evaluation of the patient's health status. Elevated PCT serum level is correlated with progression and generalization of the infection. In severe infections, such as sepsis or septic shock, the PCT may reach concentrations even up to 1000 ng/ml (with a normal range below 0.1 ng/ml). High PCT levels in the first hours of the developing infection advocates for the bacterial etiology. Therefore, procalcitonin is used in differential diagnosis of severe bacterial and viral infections. Rapid and accurate diagnosis facilitates introduction of the effective therapy. Rapid decrease in PCT level after applying the therapy confirms its efficacy (control assay may be performed after 24 hours since the therapy has been applied). The usefulness of the PCT is supported by the fact, that in pathologic conditions, such as trauma (including surgery procedures), viral infections or autoimmunologic diseases, the PCT level is only slightly increased or remains in a normal range. The PCT level assay enables the detection of the developing infection already in the latent stadium, before characteristic clinical symptoms appear. Therefore, it is very important to monitor the PCT serum level. Further research will allow to determine the accurate diagnostic value and the clinical application of the PCT level as a marker of infection.
Pol Merkur Lekarski 2009 Dec
PMID:[Procalcitonin in diagnosis and monitoring of surgical infections]. 2012 Jul 20

Authors present early results of Scorpio TS prosthesis in primary and revision total knee arthoplasty due to aseptic and septic loosening. 26 arthroplasties were performed on 25 patients. There were 19 women and 6 men of age from 37 to 80 (average 68.4 years). 11 patients from this group were operated because of septic loosening. The follow up from 2 to 22 months (average 11 months). Early results were access according to Clinical Rating System of The Knee Society: 19 patients had very good and good (73%) including primaries, 1 satisfactory (4%) and 6 poor (23%) results. The satisfactory and poor results were obtained in 7 cases with septic loosening who had had four or more previous operations on the knee. Four of them had instability of prosthesis and we changed it for MRH type. In one case due to reinfection and sepsis amputation above the knee was performed. In another patient tibia fracture below stem and loosening of tibial component occurs after 6 months of revision. ORIF gave fracture union after 8 months and exchange Scorpio TS to MRH was performed. In two cases the wound problems occurred and was solved. There were no reinfection and aseptic loosening in another cases. We didn't notice any thrombosis complications.
Chir Narzadow Ruchu Ortop Pol
PMID:[Scorpio TS prosthesis in severe deformity and revision knee arthroplasty--preliminary report]. 2020 29

We report the case of a 17 year-old girl who developed sepsis due to Methicillin-Resistant Staphyloccocus Epidermidis (MRSE) infection of Dacron patch 14 years after ventricular septal defect (VSD) closure and 4 years after pacemaker implantation. Although MRSE grew in many cultures taken and proper antibiotic regimen was administered, no improvement in patient's clinical status was observed. Disseminated intravascular coagulation and multi-organ failure developed. An operation, at which perforated Dacron VSD-patch was replaced with a new Gore-Tex one, was performed by cardiac surgery team. The patient's clinical status improved immediately after the procedure. The girl remained well 12 months after discharge.
Kardiol Pol 2010 Aug
PMID:[Staphylococcal sepsis due to ventricular septal defect patch infection 14 years after its closure]. 2073 Jul 29

The number of implanted the cardiovascular implantable electronic device(s) (CIED(s))--pacemakers (PM) and implantable cardioverters defibrillators (ICD)--increases each year. The number of CIED(s) exchange procedures as well as changes in models of stimulation (upgrade to dual chamber pacemakers or three chamber cardiac resynchronization therapy devices) also grows. Also increases the inactive electrode left in the cardiovascular system. The risk of infection is higher during the exchange of devices than with their implantation. Treatments for patients with multiple electrode systems are becoming a potential source of infection. The incidence of damage defibrillator is greater than pacemaker leads. Intracardiac electrodes causes the growth of connective tissue, fibrosis in the venous system and may cause obstruction subclavian vein or brachiocephalic preventing implantation needed a new electrode. Damaged and broken electrodes may migrate to the cavities of the heart. This increases the risk of thrombosis, pulmonary embolism, tricuspid valve dysfunction and serious arrhythmias. All these facts presented lead to the conclusion that the growing need to remove the electrodes (both infected and inactive) pacemaker or cardioverter defibrillator. There are two classes of indications to remove the electrodes. Procedures for removing the benefits must outweigh the risks. Should be considered for each patient individually and take into account the experience of the operator and its results. Class I indications are: lead dependent endocarditis, sepsis, arrhythmias or embolism secondary to the presence of lead, venous occlusion prevents the implantation of new electrodes, interference between the electrodes, an implantable device infection box. Class II includes: chronic pain in the area and inactive pacemaker electrodes in young people. After removal must be individually examined whether there is a need to implant the new layout. It should not be implanted in a place that has previously been infected. The preferred area is the opposite, iliac vein, reaching epicardial implantation.
Pol Merkur Lekarski 2010 Mar
PMID:[Indications for the procedure for transvenous removing of electrodes based on the guidelines of U.S. societies]. 2081 63

A 28 year old woman with a specific phobia of being in hospital, three hours after having given birth to her baby, demanded to be discharged from the hospital, in spite of having been informed by the obstetrician that her life was threatened because of an intrauterine infection that might cause sepsis. The patient decided to stay in hospital after several long-lasting psychiatric consultations including psychotherapeutic interventions. The patient did not recognise that her fear was excessive and unreasonable, i.e., did not meet one of the criteria of specific phobia. She gradually regained criticism toward her symptoms within approximately one day. This indicates that patients with specific phobia confronted with a phobic situation may temporarily loose awareness that their fears are unreasonable and/or too intensive and may express beliefs similar to psychotic delusions. This situation faced the team of doctors with potential legal problems that might appear if the patient had definitely refused to stay in the hospital. Polish law does not allow to treat such patients against their will on non-psychiatric hospital wards. However, in the case ofa definite phobia diagnosis there is no legal way to hospitalise a patient against his or her will on a psychiatric ward.
Psychiatr Pol
PMID:[Specific phobia in early period of puerperium. Case report and its legal aspects]. 2091 9

Inadvertent lead implantation into the left ventricle (LV) is a rare but serious complication of permanent pacing and should be diagnosed as soon as possible. We report a case of a patient with a pacemaker pocket infection with sepsis and two ventricular leads - one old electrode abandoned in the right ventricle and another one unintentionally implanted via patent foramen ovale into the LV. Both leads were extracted percutaneously, although the procedure was complicated by a minor ischaemic stroke.
Kardiol Pol 2011
PMID:Transvenous extraction of a five year-old ventricular lead inadvertently implanted in the left ventricle. 2167 12


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