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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During bacterial infections, the intensity of the polymorphonuclear leukocytosis depends on the bacterium but also on the mechanism and extent of the infection. Polymorphonuclear leukocytosis is greater during pyogenic and anaerobic infections. It is due to deep suppuration, septicemia of thrombophlebitic origin, acute endocarditis, purulent meningitis and pneumonia. The increase in the number of polymorphonuclear cells is, on the other hand, less marked in sub-acute bacterial endocarditis. Apart from bacterial infections, a polymorphonuclear leukocytosis is common in inflammatory disease, such as tissue necrosis and several malignant diseases. It may also be due to drug allergy.
Sem Hop 1975 Feb 26
PMID:[Leukocytosis and polynucleosis in infectious disease]. 17 54

The association of carbenicillin and gentamicin was used as a routine in the early treatment of 48 attacks of fever, in 38 patients who mostly had acute leukemia and marrow aplasia. The attacks of infection may be classified as follows: 30% septicemia, 30% local infections, 40% no bacteria were identified. Among the septicemias, we noted 5 septicemias due to pyocyaneus, 4 due to klebsiella. On the whole, in the attacks of fever, the association of carbenicillin and gentamicin proved effective in 70% of cases, but a cure was obtained in only 56% of cases. In vitro, the association carbenicillin-gentamicin proved justified in 70% of cases. There was no special intolerance, apart from a few cases of hypokalemic alkalosis. The association carbenicillin-gentamicin, by its broad spectrum and especially in view of its elective effect on the pyocyaneus is an excellent initial form of antibiotic therapy, when faced with infection in a patient with malignant blood disease. However, it should be recognised that the efficacy of this association depends on the number of circulating polynuclear cells and that some bacteria, such as the klebsiella, are clear cells and that some bacteria, such as the klebsiella, are often resistant to this antibiotic association.
Sem Hop 1975 Jun 14
PMID:[Infections during malignant blood diseases. Value of the carbenicillin-gentamicin combination]. 18 Jun 8

Septicemia is a complication of prolonged venous catheterisation; although rare, is at present important owing to the severity of the condition and the possibility of prevention. The severity should lead one to very careful precautions to avoid sepsis, which antibiotic therapy and emergencies often lead one to neglect. The development of research on the prophylaxis of septicemia suggests that in the future, prolonged intravenous fluid may be given less dangerously. They are usually essential during the initial stages of intensive care.
Sem Hop 1975 Jun 14
PMID:[Septicemic complications of venous perfusion catheterization. 4 years' experience in an intensive care unit]. 18 Jun 10

The authors present 31 cases of acute agranulocytosis due to drugs. 27 resulted from amidopyrine poisoning and 4 were due to phenothiazines. The clinical picture in most cases, was that of severe septicemia with lesions of the mucosae. On blood count agranulocytosis was complete, associated on bone marrow examination with an appearance of selective hypoplasia of the granular series or an aspect of maturation blockage at the stage of the myelocyte or the metamyelocyte. The course was fatal in 6 cases. A search for leukocyte agglutinating antibodies, carried out in 29 cases, was positive in only 5 cases. These facts correspond, on the whole, to the, clinical and etiological data found in the literature. Although the agranulocytoses induced by phenothiazines, seem to be mainly of toxic origin, the agranulocytoses induced by amidopyrine associated both an immunological mechanism and a toxic mechanism. Among all the biological tests proposed, the most useful is the le ukocyte agglutination test, but the serological diagnosis is rarely conclusive.
Sem Hop
PMID:[Acute agranulocytosis induced by pyramidon or phenothiazines. Apropos of 31 cases]. 18 47

Infective complications are analysed in 100 transplanted patients all receiving corticosteroid and azathioprine. 170 infective episodes were noted, only 13 patients never had infection during the period of observation. Two complications were dominated by their gravity : pneumopathies (n equals 29) fatal in 20.6% of cases, and septicemia (n equals 21) fatal in 28.5% of cases. Alone they represented 75% of the overall mortality in this series. More than 50% of failures due to death or detransplantation, were directly due to infection. The results show that this type of complication represents the main limiting factor to renal grafts in patients submitted to immunosuppressor treatment which depresses non-specifically, the whole immune response.
Sem Hop
PMID:[Infectious problems posed by patients with a renal graft and submitted to an immunosuppressive treatment]. 18 72

Organ transplantation and the modern treatment of leukemia have created a new situation favouring bacterial infection under immunosuppressive drugs. Exceptionally, due to pathogenic bacteria, these infections are usually due to various germs normally considered as inoffensive saprophytes, which may thus reveal immune deficiency in the patient. This immune failure, which is very pronounced in treated leukemic patients and following transplantation, is on the contrary often localised at a precise level during common infections. Knowledge of these levels is thus essential for the clinician who, in all infected patients, should assess the state of the skin, mucosal and tissue and humoral defences whether specific or non-specific in the light of modern immunological data. Infection in the immunodepressed subject requires urget treatment. Antibiotics are not the only form of treatment, one should supervise, maintain and restore adequate immune levels. Furthermore, antibiotics alone, although they reduce the frequency, do not finally improve the mortality rate from gram-negative septicemia acquired in hospital.
Sem Hop 1976 Jan 09
PMID:[Bacterial infections and immunosuppression]. 18 4

During acute lymphoblastic leukemia in children, bacterial infections occur during initial treatment, whereas virus infections are observed during remission. Mycoses and pneumocystis carinii infections are the commonest late complications. During agranulocytosis, any prolonged fever should be considered as due to infection and probably septicemia. The bacteria are usually of digestive origin. Antibiotic therapy is only very inconstantly efficacious, and the course follows closely the number of granular cells, thus justifying the use of white cell transfusions.
Sem Hop 1976 Jan 09
PMID:[Infectious complications observed during the use of antimitotic agents in hematology]. 18 5

The authors report a case of fungal septicemia due to Torulopsis glabrata, an unusual cause of fungus infections. This case was of interest clinically in view of the duration and tenacity of the infection on a surgical unit, where repeated blood cultures were positive for Torulopsis glabrata and the fungus was isolated from other samples during the same period. In the laboratory, the species identified was a common saprophyte of the mucosae and natural cavities of man; it seems to be only rarely pathogenic. Finally the course marked by numerous relapses was later favourable thanks to the use of antifungal agents chosen in the light of laboratory examinations.
Sem Hop 1976 Jan 16
PMID:[Septicemia due to Torulopsis glabrata]. 18 71

This work regroups an important number of acute pneumococcal infections with septicemia, which recalls that these infections are of current importance, owing to their frequency and poor prognosis. Present diagnositc, clinical, radiological and bacteriological methods are discussed and criticised. An important, but not exclusive place, is reserved for routine blood culture. Finally, the authors discuss future prospects of acute pneumococcal infections, mainly diagnostic and prophylactic.
Sem Hop 1977 Jan 23
PMID:[Current place of the Pneumococcus in infectious pathology]. 18 34

The authors report a statistical analysis of 163 operations of aorto-iliac vascular surgery. A detailed study of their 14 deaths showed the various causes of mortality (immediate post-operative thrombosis, acute renal failure, digestive complications, septic cardiac, pulmonary, hemorrhagic and cerebro-vascular accidents). This analysis, compared with the findings in all the operated patients showed the main factors of risk in this type of surgery (age over 70 years immediate and late reoperations, heart lesions, renal, pulmonary and late lesions, the risk of sepsis). The indicate the means of prevention of such accidents and the therapeutic attitude when they occur. They conclude that the contra-indications are relative, but should be observed in order to lower the risk of this surgery below 5 p. cent mortality rate.
Sem Hop
PMID:[Risk factors in aorto-iliac surgery (author's transl)]. 21 67


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