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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gentamicin in combination with other antibiotics is frequently used in the treatment of postpartum endomyometritis. The need to monitor and maintain therapeutic concentrations, however, is controversial. To assess the role of monitoring, serum gentamicin concentrations were prospectively studied in an obstetric population treated for postpartum endomyometritis. Clinical course was correlated to serum gentamicin levels obtained using a 1 mg/kg/dose regimen. No patient demonstrated therapeutic concentrations. Sixteen of 18 obstetric patients (88%) exhibited a clinical response despite subtherapeutic serum gentamicin concentrations. The two failures included one case of septicemia and one wound seroma. Serum gentamicin levels of this obstetric population when compared to those from a gynecologic population treated for benign disease demonstrated no statistical difference. These data suggest that clinical response provides an accurate indication of the efficacy of therapy and that gentamicin doses of 1 mg/kg/dose provide sufficient antibiotic coverage in most cases. These results do not support the use of increased gentamicin dosages and the need to attain therapeutic levels in the obstetric patient, as previously suggested.
Mil Med 1992 Oct
PMID:Serum gentamicin concentrations in postpartum endomyometritis. 145 74

We report a case of cellulitis, compartment syndrome, and septicemia associated with fish handling. The etiologic pathogen isolated from the wound and blood cultures was Plesiomonas shigelloides. The pathogen can cause serious illness in people handling fish.
Mil Med 1991 Jan
PMID:Cellulitis and compartment syndrome due to Plesiomonas shigelloides: a case report. 190 Jan 18

In order to determine the relationship of blood culture results and septicemia-related diagnoses, laboratory and patient chart records were evaluated on 25 intensive care unit patients who were hospitalized in 1989. Overall, there were 14 in whom the DRG and blood culture results were both positive, 4 with positive DRGs and negative blood cultures, and 7 with negative DRGs and positive blood cultures. These findings suggest that neither positive blood culture results nor diagnosis codes are entirely accurate indicators of the overall incidence of septicemia, and that the two indicators were not closely associated in our hospital.
Mil Med 1991 Sep
PMID:The relationship of septicemia-related diagnoses and positive blood cultures. 196 25

Extracorporeal membrane oxygenation (ECMO) is used in the treatment of reversible pulmonary disease in the newborn. The ECMO program at Wilford Hall USAF Medical Center began in 1985 and to date, 57 patients have been placed on bypass for a mean of 125 hours. The indications for ECMO are severe, prolonged hypoxemia in patients with an estimated mortality of greater than 90% using conventional ventilator support. The major diagnoses in the patients placed on ECMO were meconium aspiration, congenital diaphragmatic hernia, and neonatal sepsis or pneumonia. Overall survival was 79%, or 45 out of 57. The most frequent complications were intracranial hemorrhage as well as hemorrhage from the surgical site. We have found ECMO to be an extremely valuable adjunct in the care of the critically ill newborn and believe it can significantly improve survival in infants with reversible pulmonary disease.
Mil Med 1990 Aug
PMID:Extracorporeal membrane oxygenation in the newborn. 211 22

Sixty-eight semipermanent subclavian catheters were placed in 61 patients with gynecologic malignancies. The principal indicator for placement was chemotherapeutic administration. Other uses included blood transfusion, antibiotic infusion, and hyperalimentation. The minor complication rate of 21% included exit site infections and clotted, broken, and dislodged catheters. There were no acute surgical complications; i.e., bleeding or pneumothorax, but there was a 6% major complication rate, which included four cases of sepsis and a case of a broken intravascular catheter.
Mil Med 1990 Oct
PMID:Evaluation of subclavian catheters in gynecologic cancer patients. 212 89

War wounds are characterized by devitalized tissue, the presence of debris, and contamination by bacteria--factors that contribute to the establishment of wound infection. A review of the literature regarding the incidence of wound infection in recent military conflicts strongly suggests that infection in open war wounds occurs with relative frequency despite strict adherence to the principles of surgical debridement and administration of "prophylactic" antibiotics. Further research leading to improved methods of preventing wound sepsis is warranted in order to reduce the incidence of wound infections in the future.
Mil Med 1989 Jun
PMID:Infection in war wounds: experience in recent military conflicts and future considerations. 249 67

Data on 109,312 singleton births at U.S. Army hospitals over 3 years were examined to determine differences in perinatal risk factors between infants with a diagnosis of sepsis confirmed by blood culture and those whose cultures remained negative. The incidence of confirmed sepsis (1.1/1000 live births) and the importance of perinatal complications and prematurity were consistent with other reported findings. No reliable indicators of bacteremia that could be used in conjunction with other clinical data were found. These findings support continued empiric therapy in infants at risk until infection can be verified by culture.
Mil Med 1989 Nov
PMID:A survey of infants with neonatal sepsis in U.S. Army hospitals. 251 12

From May 21 to June 4, 1993, a collaborative training project involving U.S. Army veterinary personnel, the Lao-American Integrated Rural Development Project, and the Lao Department of Livestock and Veterinary Services occurred in the Houa Muang District of Houa Phan Province in northeastern Laos. The project focus was control of the major animal diseases of economic or public health importance in the area to include, but not limited to, hemorrhagic septicemia, anthrax, swine fever (hog cholera), and Newcastle disease. The project provided Lao veterinary personnel and villagers with didactic training and field demonstrations in disease control practices. Supplies and equipment necessary to continue disease control activities were provided to the district at the conclusion of the training and field demonstrations. The project was designed to be compatible with disease reporting and surveillance systems at district, province, and national levels and be exportable to other districts and provinces. In addition to disease-control efforts, blood and fecal parasite surveys were conducted.
Mil Med 1994 Oct
PMID:Lao People's Democratic Republic Veterinary Public Health Project. 787 Mar 20

The morbidity and mortality occurring during 25 years following spinal cord injury were analyzed. A cohort of 230 patients was selected from the Vietnam Head and Spinal Cord Injury Study Registry meeting the following criteria: (1) survival beyond triage (72 hours); (2) significant myelopathy; and (3) availability of medical records. The military and Veteran's Hospital medical records were compiled and reviewed. Additional death records were obtained from the Department of Veterans Affairs pension office. The major morbidity problems continue to be sepsis related to genitourinary and decubiti sequelae. Psychosocial maladjustment and substance abuse were prevalent and created heavy health care demand. The most frequent cause of death was sepsis. Suicide in the paraplegic group occurred at a rate exceeding by 10 times the frequency reported for uninjured peers. Survival after 5 years approached but never reached the rate established for uninjured peers.
Mil Med 1997 Feb
PMID:Spinal cord injury: a 25-year morbidity and mortality study. 915 96

Gut-origin sepsis is a serious medical complication of military injuries following hemorrhage. Splanchnic ischemia induces intestinal necrosis leading to systemic bacteremia. Rat and mouse models of hemorrhagic shock were used to investigate bacterial translocation from the gut. Orally administered ameliorative treatments using the cytokine interleukin-6 (IL-6) were able to reduce or eliminate sepsis following hemorrhage. To mimic battlefield wounds and hemorrhage, anesthetized mice were bled from the femoral artery, held at a mean arterial blood pressure of 35 mm Hg for 1 hour, and then resuscitated with shed blood and 2-fold volume lactated Ringer's solution. Anesthetized rats were bled from the carotid artery at a rate of 15 ml/kg at 1 ml/minute. Bacteriological cultures of livers and mesenteric lymph nodes from hemorrhaged animals given recombinant IL-6 had significantly fewer colonies per gram of tissue than saline-fed controls. 125I-labeled IL-6 remained in the gut for up to 6 hours giving regional protection, whereas labeled interleukin-2 was disseminated throughout the body in the same time. In vivo and vitro studies of IL-6 showed that long incubations with high doses of trypsin, chymotrypsin, or intestinal contents were necessary to inactivate the bioactivity of this cytokine. Electron microscopy showed that epithelial cells from hemorrhaged mice fed saline had sparse or missing villi and vacuolated cytoplasm. Epithelial cells from control mice or mice hemorrhaged and fed cytokine appeared completely normal. Oral administration of IL-6 on the battlefield may be an important treatment for the prevention of sepsis following hemorrhage.
Mil Med 1997 May
PMID:Systemic sepsis following hemorrhagic shock: alleviation with oral interleukin-6. 915 11


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