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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The first home dialysis was carried out from Guy's Hospital in London in 1968. Since then, 141 patients have been treated in this manner. The age of the patients ranged from 4 to 64 years. 24 patients have died (cerebrovascular accidents, myocardial infarction, pulmonary edema, sepsis, peritonitis, hyperkalemia etc.). Some of the deaths were due to a slackening of discipline on the part of the patients and nursing staff during the years of constant dialysis. Of 60 adults 52 were able to start work again; full rehabilitation still seems possible in 6 cases. Nevertheless, many patients cannot lead a normal life because their social and sexual activity is greatly restricted. The present economic crisis led to financial limitations in the National Health Service. In future, home dialysis may have to be reduced and more transplantations performed.
MMW Munch Med Wochenschr 1977 Dec 23
PMID:[Guy's Hospital home dialysis program (author's transl)]. 41 3

Eighty four cases of meningococcal infections are reviewed. Fifty seven cases presented themselfs as meningococcal meningitis, twelve cases as sepsis with moderate hypotension and 15 cases were sepsis with septic shock. A brief course of the disease, shock, echymosis, absence of meningeal signs, leucopenia and intravascular coagulation were findings more frequent in the group of patients with hiperacute sepsis, whereas other signs as fever, headaches, vomiting and petechiae were present with equal frequency in the three groups. N. meningitis was isolated in 73% of the cases. Shock (18.85%) and intravascular coagulation (12%) were the complications more frequently found, followed by convulsions (4.81%), arthritis (4.81%), skin necrosis (4.81%), subdural efusion (3.57%), cerebral palsy (3.40%), thrombophlebitis (1.20%), recurrence (1.20%), inapropiate antidiuretic hormone secretion (1.20%) and subaracnoideal hemorrage (1.20%). The overall mortality was 10.70% and 60% of the patients which initially presented with shock and intravascular coagulation died. Autopsy findings included wide spred hemorragic lesions and intravascular thrombi in skin, mucous membranes and viscera. Adrenal hemorrhage was present in five of the six cases studied.
An Esp Pediatr 1977 Dec
PMID:[Incidence, clinical, forms and complications of meningococcal infections (author's transl)]. 41 52

Bacteremia following endoscopy of the gastrointestinal tract in patients with impaired resistance even fatal septicemia has been reported. Transmission of pathogenic bacterias via endoscopes has been described. We could demonstrate a considerable high number of gramnegative bacteria obtained from biopsy channel of fiberendoscopes after conventionell cleaning of the instruments. In seven different endoscopy units we found high bacterial contamination of all 22 fiberendoscopes. Pseudomonas aeruginosa in concentrations up to 4 X 10(6)/ml was cultivated on the instruments including cleaning utilities (flasks etc., Table 1). The new apparatus we demonstrate here has the advantage of cleaning and disinfecting the endoscopes. One or two endoscopes are placed into a U-shaped pipe which is interconnected with a pumping system. In this automatic apparatus a disinfectant which recycles through all channels is used (Fig. 1). We investigated solutions of 2% glutardialdehyde, of 5% succindialdehyde respectively 1% peracetic acid. Disinfection of instruments was effective. No bacteria could be detected in material obtained from biopsy channels, HBsAg also could not be detected on the instruments after this procedure. The use of dialdehyde is recommended.
Zentralbl Bakteriol Orig B 1977 Dec
PMID:[Automatic disinfection of fiberendoscopes (author's transl)]. 41 28

During caloric deprivation, the septic host may fail to develop ketonemia as an adaptation to starvation. Because the plasma ketone body concentration is a function of the ratio of hepatic production and peripheral usage, a pneumococcal sepsis model was used in rats to measure the complex metabolic events that could account for this failure, including the effects of infection on lipolysis and esterification in adipose tissue, fatty acid transport in plasma and the rates of hepatic ketogenesis and whole body oxidation of ketones. Some of the studies were repeated with tularemia as the model infection. From these studies, it was concluded that during pneumococcal sepsis, the failure of rats to become ketonemic during caloric deprivation was the result of reduced ketogenic capacity of the liver and a possibly decreased hepatic supply of fatty acids. The latter appeared to be a secondary consequence of a severe reduction in circulating plasma albumin, the major transport protein for fatty acids, with no effect on the degree of saturation of the albumin with free fatty acids. Also, the infection had no significant effect on the rate of lipolysis or release of fatty acids from adipose tissue. Ketone body usage (oxidation) was either unaffected or reduced during pneumococcal sepsis in rats. Thus, a reduced rate of ketone production in the infected host was primarily responsible for the failure to develop starvation ketonemia under these conditions. The liver of the infected rat host appears to shuttle the fatty acids away from beta-oxidation and ketogenesis and toward triglyceride production, with resulting hepatocellular fatty metamorphosis.
J Clin Invest 1979 Dec
PMID:Role of the liver in regulation of ketone body production during sepsis. 50 Aug 25

Postoperative sepsis developed in 72 per cent of 25 patients with noncalculous proximal biliary tract obstruction. Six episodes of shock and one death resulted. Twenty-eight per cent of septic events occurred despite the administration of prophylactic antibiotics. The incidence of septic complications was similar regardless of the biliary drainage procedure used. Despite the advent of broad spectrum antibiotics and improved surgical techniques for biliary decompression, sepsis remains a serious and frequent complication in patients with chronic bile duct obstruction.
Am J Surg 1979 Dec
PMID:Sepsis in the management of complicated biliary disorders. 50 97

Very significant morbidity and mortality continue to accompany lower extremity amputations. In this study 90 patients underwent 110 amputations over a 4 year period. The overall complication rate was 40 per cent and the overall mortality rate 12.2 per cent. The patients at greatest risk were the above knee amputees greater than 60 years of age with peripheral vascular disease. Amputation of the lower extremity must be recognized as a major, life-threatening procedure. Careful preoperative evaluation of cardiac, pulmonary, and nutritional status along with efforts to prevent sepsis, pneumonia, pulmonary embolism, gastrointestinal ulceration, and renal failure are necessary if the mortality accompanying these procedures is to be reduced.
Am J Surg 1979 Dec
PMID:Lower extremity amputation: review of 110 cases. 50 12

The disadvantages of external ventricular drainage are the threat of sepsis and the nuisance of dislodging a precarious system in routine care. The experience of the authors with nearly 200 cases using a long ventricular catheter demonstrates that a subgaleal tunnel can be easily made for the ventricular catheter using a sharp trocar. The resulting system is secured by the tunnel, easily dressed, and has a minimal likelihood of sepsis. Although external drainage has been maintained for longer than 3 weeks in some cases, the average duration is 6 days; and in the last 68 cases, there has been no incidence of sepsis and but one case of patient removal of the catheter. The device has been used for both monitoring, as well as ventricular decompression in a broad range of patients.
Crit Care Med 1979 Dec
PMID:External ventricular drainage. A technical note. 50 70

An office myringotomy is an easily performed, underused procedure which has definite clinical applications. The family physician should become familiar with the technique, its indications and its complications. Indications include otitis media with concomitant meningitis, with matoiditis or with cranial nerve involvement, and otitis media in an immunocompromised patient, in a neonate with signs of sepsis or in a very sick, toxic child. If the incision is made in the lower portion of the tympanic membrane, complications are rare.
Am Fam Physician 1979 Dec
PMID:Myringotomy: a neglected office procedure. 51 78

Two sources of septic toxemia--microbial and metabolic--were found in a detailed analysis of 37 patients with pronounced symptoms of sepsis. The proposed three-degrees classification of septic toxemia based upon the degree of clinical signs and humoral reactions, gives sufficient information, partically useful for a more objective estimation of the patients' state, to choose a purposeful therapy of sepsis and real ideas of the prognosis. In addition to the active antimicrobial therapy with using powerful antiseptics (sulfamilon, chlorophilipt, gentamycin, ceporin etc.) the authors insist on hemotransfusions (direct hemotransfusions included) in order to liquidate progressing anemia and to perform nonspecific detoxication by means of forced diuresis or peritoneal dialysis according to the techniques developed by the authors.
Vestn Khir Im I I Grek 1979 Dec
PMID:[Clinical characteristics of sepsis today]. 52 95

The effects of three final filter pore sizes on sepsis and survival times in rabbits infused with contaiminated intravenous fluids were compared. Intravenous fluids were administered for up to 12 hours to five groups of rabbits. Groups 2, 3 and 4 received fluids, contaminated with Gram-negative rods, that were filtered with 0.22-, 1.0- and 5.0-micrometers filters, respectively. Rabbits in Groups 1 and 5 received uncontaminated and contaminated fluids, respectively, neither of which was filtered. Cultures were taken of blood and of fluid below the filters, and rabbit survival times were recorded. At 6, 8 and 12 hours, Group 2 survival time was not significantly different from that of the negative control; the survival times for Groups 3, 4 and 5 were significantly less than for the negative control. Fluid and blood cultures of Group 2 were negative or statistically indistinguishable from those of Group 1. Cultures for Groups 3, 4 and 5 were positive. The study suggests that 1.0- and 5.0-micrometers inline final filters have no beneficial effect on survival following infusion of contaminated fluids, but that 0.22-micrometer inline final filters increase survival time.
Am J Hosp Pharm 1979 Dec
PMID:Sepsis in rabbits following administration of contaminated infusions through filters of various pore sizes. 52 50


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