Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-three total hip prostheses were inserted in 33 adults suffering from a chronic high dislocation of the hip. Ten patients had a bilateral arthroplasty. The authors decided to keep in this series only hips presenting with a very considerable upward displacement of the femoral head of type IV in Crowe, Maini and Ranawat's classification. All the hips were treated in the same way with pre-operative planning using template tracings to anticipate problems of length and choice of implant. The acetabular cup was placed in the old acetabulum with downward displacement of the femur. The results were studied in 39 prostheses with a mean follow-up of five-and-a-half years (two years to nine-and-a-half years). The mean age of the patients was 48 and-a-half years (28 to 76 years). A satisfactory result was obtained in 79.5 per cent of cases. The mean downward displacement of the femur was 4.8 cm. Complications included one death from pulmonary embolus, two phlebitides, two fractures of the femoral shaft and four dislocations. There were nos cases of sepsis or neurological complications. The authors advise the use of custom-made implants, consider the tactical problems relative to the opposite hip. It is concluded that the value of the method often lies in the transformation of the life of these young patients by a "functional miracle", but the operative indications need to be considered carefully, since the procedures are sometimes extensive, often difficult and always require technical skill.
Rev Chir Orthop Reparatrice Appar Mot 1988
PMID:[Treatment of chronic hip dislocation in adults by recentered total prosthesis. Apropos of 43 cases]. 306 46

The role of motility as a virulence factor in Pseudomonas aeruginosa burn wound sepsis was examined using mutants deficient in the Fla or Mot phenotype. Physiological profiles of parental strains and Fla- and Mot- mutants were similar with respect to antibiograms, O antigen types, growth rates, and proteolytic, exotoxin A and phospholipase activities, providing evidence for isogenicity. Lethality studies using a subcutaneous mouse burn model showed that three Fla- mutants and one Mot- mutant were much less virulent (10(2) to 10(5) times) than the parent wild-type. Topical challenges in the flame burn model showed that a Fla- mutant of strain M-2 was approximately tenfold less virulent. A reduction in virulence, although somewhat less than tenfold, was also observed in the scald burn model for M-2 Fla-, and Mot- strains. Tissue colonization experiments revealed a characteristic, rapidly systemic infection in burned mice challenged with wild-type organisms. Nonmotile mutants similarly proliferated in the burn wound, but the characteristic bacteraemia and systemic invasion were markedly absent. The infection remained localized in the skin wound and the mice survived. The pattern of infection by nonmotile mutants in the colonization studies was very similar to that obtained with Fla+ cells in burned animals passively treated with antiflagellar antibody. These results add substantial support to the concept of motility as a P. aeruginosa virulence factor in invasive infections.
 ...
PMID:Flagella, motility and invasive virulence of Pseudomonas aeruginosa. 314 66

An experimental study has been made of the possibility of meniscus grafting. This was carried out in 30 merino sheep, 15 of which received lyophilised homologous menisci and 15 others deep-frozen homologous menisci. Three sheep had to be excluded because of wound breakdown and sepsis. The other animals were examined and the transplants assessed clinically, microscopically, micro-angiographically and by scanning electron microscopy over a period of 48 weeks; finally they were submitted to biomechanical tests. Both techniques are suitable for transplantation but, over the period of observation, the lyophilised grafts remodelled completely. At the end, the mechanical resistance of the meniscus was identical in the two groups.
Rev Chir Orthop Reparatrice Appar Mot 1988
PMID:[Transplantation of the meniscus. Experimental study]. 317 96

Sixty-seven cases of total arthroplasty of the hip in the presence of sepsis performed between 1974 and 1986 were reviewed. These prostheses were inserted in 57 cases to replace septic prostheses. Forty-six were infected total hip prostheses and 11 were infected head and neck replacement femoral prostheses. In 10 cases arthroplasty was performed for subacute septic arthritis, usually secondary to trauma. In seven cases, a simple revision of the prosthesis by excision and lavage of infected tissues was performed. In 51 cases, a total hip replacement arthroplasty was performed in one stage. When one of the components was not loose it was preserved; in 17 cases the femoral cement was retained and in six the acetabular cup was retained. In eight cases, the prosthesis was removed, excision of the tissues was made and a total hip arthroplasty inserted after a minimum interval of six months. As regards infection, success was achieved in 69 per cent of cases rising to 85 per cent after secondary removal of the prosthesis. In relation to function, a good or fair result was achieved in 72 per cent of cases. The results were favourable in 81 per cent of cases with complete exchange of prostheses and in 75 per cent with preservation of the femoral cement. Preservation of the acetabular cup was only successful in 40 per cent of cases. Accessory factors in the prognosis were the addition of a bone graft, which became incorporated in 29 cases out of 30 and the nature of the organism which was of no significance, except that staphylococcus epidermidis and Koch's bacillus proved to be more easy to treat.
Rev Chir Orthop Reparatrice Appar Mot 1988
PMID:[Total hip arthroplasty in the presence of sepsis]. 317 4

The authors have performed 18 operative procedures to remove bony bridges across the growth plate in children. The causes of the formation of the bone bridge were many, including 10 after injury and 3 after infection. There were 9 good results and 9 failures. The causes of the failures were the extent of the bone bridge, sepsis as the causative lesion and technical errors during operation. The best results were obtained in cases where the bridge was peripheral, was easily approached and followed injury in young children. Extensive bridges located centrally had a poor prognosis. All the post-infective cases were failures.
Rev Chir Orthop Reparatrice Appar Mot 1986
PMID:[Epiphyseal closure correction in children. Apropos of 18 cases]. 356 33

Eleven cases of slipped upper femoral epiphysis have been corrected and fixed, using Dunn's technique. Seven were chronic slips and four were acute slips with severe displacement. The children were aged between 11 and 15 years. The displacement was measured on lateral radiographs of the femoral neck and was type II in the acute cases and type III in chronic cases, ranging between 50 degrees and the maximum possible displacement. Acute cases were operated on between 2 and 15 days following the onset of the condition, and chronic cases were operated on between 2 and 14 months following the onset of the condition. Three acute cases were not reduced by closed methods, once because of the delay of 15 days and twice because of a deformity of the neck. In the fourth acute case closed reduction was insufficient. The follow-up was between 3 months and 10 years. There was one case of sepsis and one chondrolysis.
Rev Chir Orthop Reparatrice Appar Mot 1986
PMID:[Severe upper femoral epiphysiolysis. Invasive reduction by Dunn's technic: 11 cases]. 356 37

A report of a case of haematogenous infection of a lumbar zygapophysial joint. In spite of radiographic and bone scan findings that localised the lesion, the diagnosis was not made until an operative exploration was made, which also effected a cure. This is an unusual site for sepsis and the clinical picture can easily lead to confusion with spondylosis which is much more common.
Rev Chir Orthop Reparatrice Appar Mot 1987
PMID:[Septic arthritis of a posterior vertebral inter-apaphysial articulation. Apropos of a case]. 365 47

Forty eight progressive femoral lengthenings using the Wagner technique have been performed on patients aged between 6 and 18 years (average 12 years). The main aetiology of the shortening was congenital deformity (25 cases). The mean lengthening obtained was 5.2 cm and the greatest was 11.2 cm. Lengthening obtained was more than 20 p. 100 in six cases with an extreme of 24 p. 100. The final discrepancy was always less than 25 mm. In 6 cases this was corrected by the addition of a contralateral epiphysiodesis or tibial lengthening. Weight bearing was resumed after an average of 5-6 months. Many complications occurred. Some were minor: sepsis in the pin tracks (14 cases) or varus derotation corrected at the end of lengthening (22 cases). Some were more severe: varus deformities of more than 5 degrees (8 cases), contractures at the knee or the hip corrected by tenotomies in the course of lengthening (2 cases), subluxation of the hip or knee (5 cases), fractures, delayed unions, non-unions without infection (7 cases). The major complications were 15 severe infections, 6 of them with fractures or non-unions and 5 neurological lesions.
Rev Chir Orthop Reparatrice Appar Mot 1986
PMID:[Progressive lengthening of the femur using Wagner's technic. Apropos of 48 cases]. 382 11

Twenty-seven chondrosarcomata of the pelvis were treated by local resection with preservation of the limb. Twenty-two were grade I or II, and 5 were grade III or IV. Attention is drawn to the importance of tomodensitometry in assessing the extent of the tumor before operation. An en bloc resection was well wide of the tumour in 16 cases, close to the tumour in 10 cases and involved the tumour in one case. Post-operative complications were varied. There were 6 nerve paralyses after iliac resection, 3 cases of sepsis after resection of the anterior part of the pelvic ring, and 3 cases of sepsis and 2 vascular complications after peri-acetabular resections. The average follow-up was 5 years. Three had metastases and three had local recurrences, one of whom died later from pulmonary metastases. No local recuRrence was seen in cases with wide resection. The functional results were satisfactory in 6 out of 7 partial resections of the ilium and in 4 out of 5 resections of the anterior part of the pelvic ring. They were only fair after peri-acetabular resections and complete resections of the ilium. After peri-acetabular resections, the results were about the same after ilio-femoral arthrodesis or Girdlestone operations. It is not appropriate to reconstruct the pelvic ring after resection limited to the anterior part of the pelvis but it is indicated after resections of the whole of the ilium, particularly in children to avoid shortening of the limb with pelvic shift.
Rev Chir Orthop Reparatrice Appar Mot 1985
PMID:[Resection with preservation of the lower limb in chondrosarcoma of the pelvis]. 408 64

The authors have operated on 38 patients using an original type of unconstrained prosthesis with fixation to the acromion. One prosthesis had to be removed for sepsis, 5 have dislocated and 32 are stable. Most of the cases were improved as regards pain but 14 shoulders remained very stiff. The indications for surgery are discussed, the state of the rotator cuff being particularly important.
Rev Chir Orthop Reparatrice Appar Mot 1982
PMID:[Total shoulder replacement by an unconstrained prosthesis. Report of 38 cases (author's transl)]. 621 90


<< Previous 1 2 3 4 Next >>