Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036690 (
sepsis
)
59,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aspoxicillin
(
ASPC
) was evaluated for its efficacy and safety in 30 infants and children with acute bacterial infections. The disease categories included acute respiratory tract (22), soft tissue (3), urinary tract (3) infections,
sepsis
with pyothorax (1) and purulent meningitis (1).
ASPC
was effective in all but 1 case of pneumonia due to beta-lactamase-positive H. influenzae (effective rate; 96.7%). Adverse reactions and abnormalities of the laboratory tests were not associated with the
ASPC
therapy in any of the cases. The serum half-life of
ASPC
after an intravenous bolus injection was 0.883 +/- 0.194 hour and excretion into urine was rapid. From the present results,
ASPC
is a safe and effective antibiotic when used in patients with susceptible bacterial infections.
...
PMID:[Clinical evaluation of a new parenteral penicillin, aspoxicillin, in children]. 406 22
