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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

I refer for termination anyone who requests it for--pace Mr V Tunkel, (28 July, p 253)--the law is generally regarded as being one of "abortion on demand." I have some misgivings as I do not believe that women in early pregnancy are always in a fit state to make a considered decision, and they cannot in the nature of things be given time. I have, however, become increasingly worried about the morbidity arising from the procedure, and it is interesting that letters on the subject (25 August, pp 495 and 496) should be followed by one reporting rupture of the uterus during prostaglandin-induced abortion--yet another complication to add to those of cervical incompetence, pelvic sepsis, and permanent neurological damage. In so far as these tragedies usually follow late terminations Mr John Corrie's Bill is to be welcomed. A few further points. I am not so cynical as to think that every impregnation is the result of a thoughtless act of male lust. Unlike Professor Peter Huntingford (25 August, p 496), I listen to men as well as women, and many of them are deeply involved emotionally in the pregnancy they have helped to produce. Certainly I think a man should have the right to be consulted if his wife is to undergo a procedure that might damage her health. It is unfair contemptuously to dismiss as "whims" opinions that differ from ones own. These may result from genuine conscientious doubts or inability to cope from overwork and understaffing. Abortion is quite the most expensive form of contraception, and perhaps in these days of financial stringency this should be taken into account. "Bigotry" is defined in my dictionary as "blind zeal." This could be said of those who enthusiastically promote a course of action without regard to circumstances, safety, or cost.
Br Med J 1979 Sep 15
PMID:Abortion. 49 70

The clinical course of a 26 year old female patient with acute liver necrosis and coma due to hepatitis B is reported. The disturbances of conciousness had improved. The patient survived 41 days after the beginning of the coma and developed liver cell regeneration and an acute post-hepatitic liver cirrhosis. As a grave complication a septicemia with aspergillus was observed. The patient died because of gastro-intestinal hemorrhage. At autopsy there were no signs of brain edema. The treatment consisted in: daily infusions with coenzyme A, nicotinamid-adenin-dinucleotide, alpha lipoic acid and cocarboxylase to improve the metabolic disorders and the clinical picture; mannitol intravenously to prevent and to treat cerebral edema; 33 charcoal-hemoperfusions to remove toxic substances of acute liver failure. Treatment of the aspergillus infection with 5-fluorocytosine and amphotericine B and infusion of concentrated ascites led to a decompensation of liver functions. From this observation the following conclusions can be drawn: after an acute viral hepatic necrosis, new synthetic functions and improvements of the disturbed intermediary metabolism in regenerated liver-cells can eventually be seen only after twenty-four to thirty days. With systematically applicated mannitol infusions it is possible to treat cerebral edema effectively.
Klin Wochenschr 1979 Sep 17
PMID:Treatment of fulminant hepatic failure with infusions of Co-factors and mannitol and charcoal-hemoperfusions during Forty-one days. 50 61

A female paraplegic developed intraperitoneal rupture of urinary bladder seven weeks after institution of indwelling urethral catheter drainage. Blockage of the catheter precipitated this fatal event. Oliguria after an initial encouraging urinary output despite adequate fluid replacement led us to suspect bladder rupture which was confirmed by urgent cystography. Although emergency laparotomy to repair the rent in the bladder was performed, she succumbed to gram-negative septicemia. Other hazards of indwelling urethral catheter drainage even for short periods are highlighted (though the above complication itself is admittedly rare) with an oft re-emphasised plea to consider earlier the alternative modality of intermittent catheterisation or pharmacotherapy in female patients.
Paraplegia 1979 Sep
PMID:Fatal intra-peritoneal bladder rupture due to blocked catheter in a paraplegic. 50 58

Relevant data on death from abortion that occurred between 1968 and 1976 were collected from the annual reports of the Registrar of Births and Deaths in Singapore in order to analyze abortion deaths. Additional information was obtained from case records of these deaths that occurred in Kandang Kerbau Hospital for Women; this accounted for 57% of the total number of abortion deaths in Singapore. The abortion deaths were grouped into 3 trienniel periods for analysis on trends in relation to 2 major events -- the limited liberalization of abortion legislation in 1970 and the complete liberalization of abortion legislation in 1974. There was a progressive decline in the number of abortion deaths from 15 in the 1st triennium to 9 in the 3rd triennium, a 40% decline, yet abortion continued to be the primary cause of maternal death in Singapore. In 1974-1976 abortion was responsible for 34.6% of all maternal deaths. The number of obstetric deaths declined by 62.5% between the 1st and 3rd triennium. The number of deaths from illegally induced abortions declined from 8 in 1968-1970 period to 1 in 1974-1976, yet there were abortion deaths in each triennium that were not specified as induced or spontaneous. The majority of abortion deaths occurred in the active reproductive age group of 20-39 years. The primary cause of abortion deaths was sepsis. Out of a total of 37 abortion deaths in Singapore, 21 occurred in the Kandang Kerbau Hospital for Women. None of the deaths that occurred in the 3rd triennium was the result of criminal abortion.
Singapore Med J 1979 Sep
PMID:Abortion deaths in Singapore (1968-1976). 50 38

Ceforanide, a new cephalosporin antibiotic with a long half-life (3 h), can be administered twice daily. We evaluated its antimicrobial activity, pharmacology, and clinical efficacy. Twenty-seven patients with infections due to susceptible organisms received ceforanide, 0.5, 1, or 2 g, intramuscularly or intravenously every 12 h for 6 to 28 days. In vitro studies with the clinical isolates from 27 patients treated plus 263 additional isolates showed that ceforanide was active against cephalothin-susceptible gram-positive and gram-negative microorganisms. In addition, ceforanide inhibited 65% of cephalothin-resistant Escherichia coli and 65% of Enterobacter spp. at </=12.5 mug/ml. After a single 1-g intramuscular dose, the mean peak plasma concentration at 1 h was 48.9 mug/ml and that at 12 h was 4.7 mug/ml. Plasma accumulation occurred in some patients. The infections included 10 pneumonias, 3 with bacteremia and 1 with empyema; 11 soft tissue infections, 4 with abscesses and 3 with sepsis; and 3 urinary tract infections. One case each of endocarditis, osteomyelitis, and septic thrombophlebitis, all due to Staphylococcus aureus, were treated. Clinical response was satisfactory in all patients; bacteriological response was satisfactory in 26 of 27 patients. Ceforanide was well tolerated. Three patients developed mild increases in liver enzymes, and one developed slight eosinophilia. In another case, the antibiotic was discontinued because of a fivefold rise in serum glutamic-oxalacetic transaminase (aspartate aminotransferase) and serum glutamic-pyruvic transaminase (alanine aminotransferase) and a twofold rise in lactic acid dehydrogenase and alkaline phosphatase.
Antimicrob Agents Chemother 1979 Sep
PMID:Ceforanide: in vitro and clinical evaluation. 50 95

During 23 exchange transfusions, the granulocytes from 27 donors and 16 newborn infants were tested for opsonic activity and granulocyte function by the nitrobluetetrazolium test. Granulocyte function in a newborn baby receiving an exchange transfusion can be altered positively or negatively, depending on the quality of the donor's blood. If exchange transfusion is used in the management of neonatal sepsis, special attention should be given to the immunological properties of the donor blood.
Arch Dis Child 1979 Sep
PMID:Exchange transfusion in newborn infants: effects on granulocyte function. 51 6

Six cases of Providencia bacteremia occurring between 1969 and 1978 were reviewed. These cases represented 3% of the gram-negative bacteremias occurring at one hospital. All six cases of Providencia bacteremia were secondary to urinary tract infection with P. stuartii, and in most the infection developed only shortly before the onset of bacteremia; in three cases the bacteremia developed immediately following manipulation of the urinary tract. Patients with long-standing Providencia infections did not acquire bacteremia. The signs and symptoms of Providencia bacteremia were typical of those of septicemia except that vascular collapse was not a prominent feature, occurring in only one patient. The mortality was 33%. All the Providencia strains cultured from the bloodstream were susceptible to gentamicin, although the frequency of gentamicin resistance increased from roughly 10% to 50% during the period studied; the increase in gentamicin use over this period was more gradual. Also noted was a decrease in resistance to ampicillin that paralleled a decrease in ampicillin use. All the Providencia strains were susceptible to amikacin.
Can Med Assoc J 1979 Sep 22
PMID:A review of Providencia bacteremia in a general hospital, with a comment on patterns of antimicrobial sensitivity and use. 51 13

Sophisticated techniques for invasive and noninvasive monitoring of the cardiovascular, respiratory and metabolic consequences of shock, together with application to therapy of nutritional implications of disordered substrate metabolism that preferentially consumes vital protein stores, will result in further reduction of mortality, particularly in septic shock. Early recognition of the responsible hemodynamic abnormality and its underlying cause, followed by monitored fluid challenge and the selective rather than routine use of vasoactive drugs, is the basis of current shock therapy. As more is learned of the profound catabolic and related hyperdynamic abnormalities of severe sepsis, it is apparent that therapy will be redirected toward provision of energy substrates and altering hormonal patterns to favor anabolism.
Curr Probl Cancer 1979 Sep
PMID:Acute circulatory failure. 53 43

Acute staphylococcal sepsis is a rare complication following artificial joint replacement. Daignostic problems are due to the systemic toxic effects of staphylococci. Loosening of the prosthesis is generally observed later. For therapy of staphylococcal sepsis the prosthesis has to be changed early, using a tested antibotic mixed with the bone cement, Palacos. Prophylaxis is most important. It includes the elimination of infectious foci, the strong indication for all therapeutic measurements and the general use of the antibiotic, Gentamycin, with the bone cement, Palacos.
Chirurg 1979 Sep
PMID:[Late infections after artificial joint replacement with a septic course]. 53 69

In the period 1953 - 1977 there were 223 maternal deaths among 291 800 patients delivered in hospitals under the aegis of the Department of Obstetrics and Gynaecology of the University of Cape Town. A sudden decrease in the maternal mortality rate to below 100/100,000 deliveries occurred in 1956, largely due to the greater use of the obstetric 'flying squad'. Since 1975 maternal mortality rates have been available for the various ethnic groups. For the period 1975 - 1977 the rates were 69/100,000 for Blacks, 40/100,000 for Coloureds and 27/100000 for Whites. Of the deaths, 48% occurred in women aged 21 - 30 years and 29% in those aged 35 years or more. While 28% of deaths were associated with the first pregnancy, grand multiparity (parity 5 or more) accounted for 39%. Nearly half of the patients who died were unbooked. The 7 commonest causes (grouped) of maternal deaths (obstetric as well as non-obstetric) were, in rank order: proteinuric hypertension, haemorrhage, cardiac disease, pulmonary embolism, sepsis, trauma and anaesthetic complications. Proteinuric hypertension is the most important obstetric problem in Cape Town, in terms of numbers of patients, maternal and perinatal deaths, and socio-economic implications for the community. Slightly more than 33% of the infants whose mothers died also succumbed. Major avoidable factors associated with maternal deaths were booking status, grand multiparity, cardiac disease and late or incorrect use of the 'flying squad'.
S Afr Med J 1979 Sep 29
PMID:Trends in maternal mortality in Cape Town, 1953-1977. 55 Mar 98


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