Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Review of the coagulation laboratory records and medical records at Memorial Sloan-Kettering Cancer Center over a three year period (1971--1974) revealed 89 patients with disseminated intravascular coagulation (DIC). The diagnosis of DIC was made if laboratory studies showed evidence of quantitative and qualitative changes in fibrinogen and significant thrombocytopenia. The patients included 19 with leukemia (17 acute), 3 with multiple myeloma, 15 with lymphoma, 46 with metastatic solid tumors, (10 lung, 9 breast, 8 gastrointestinal, 12 genitourinary, 7 miscellaneous) 4 with vascular tumors, and 3 without tumor. Other conditions which might have precipitated or initiated DIC such as gram-negative sepsis, liver impairment, or mucin secreting tumors were present in the majority of patients. Bleeding occurred in 75% of the patients and was fatal in 36%. Thromboembolism occurred in 22.5%. Thirteen percent were asymptomatic. Serum lactic dehydrogenase was elevated in over 75% of the patients at the time of, or subsequent to the occurrence of DIC. Treatment with heparin was helpful in only three of twenty patients. Eighty percent of the patients died within one to over 30 days of the onset of DIC. Post mortem evidence of DIC was present in 18 of 43 autopsies. Results of this study indicate that DIC is a frequent complication of a wide variety of tumors and that its occurrence causes morbidity and mortality in a significant number of patients. Treatment with heparin is of little help unless remission is induced and the precipitating factor(s) are reversed.
Thromb Diath Haemorrh 1975 Sep 30
PMID:Disseminated intravascular coagulation: experience in a major cancer center. 17 94

Lumbar discovertebral abnormalities thought to be due to endogenous or subclinical trauma were evaluated in 22 cases. These consisted of predominantly lytic areas due to intrabody disc herniation in five cases, broad zones of vertebral body sclerosis due to reactive osteitis in 11, and destruction of the vertebral endplates surrounded by diffuse sclerosis in six. Spinal biopsy and negative bacterial cultures were consistent with the diagnosis in eight cases. Follow-up roentgenograms and further clinical evaluation in the remaining 14 showed either no progression or changes consistent with trauma. Only four cases had a history of exogenous trauma. Intrabody disc herniations usually affected the upper vertebral body with characteristic sparing of the adjacent endplate. The sclerotic lesions tended to occur in the anterior portion of the vertebral body, with the inferior aspect of L4 most frequently involved. These may be confused with osteoblastic metastases, particularly if adjacent disc narrowing is minimal. The lack of progressive vertebral fragmentation helps to distinguish this condition from neuroarthropathy. Lesions characterized by destruction of the vertebral endplates and reactive sclerosis simulate infection; absence of a soft tissue mass and clinical signs of sepsis as well as lack of progression are important differential features.
AJR Am J Roentgenol 1976 Sep
PMID:Traumatic lesions of the discovertebral junction in the lumbar spine. 18 33

A review was made of the presentation, treatment, and follow-up of 20 patients with adenoid cystic carcinoma and 12 patients with mucoepidermoid carcinoma of the bronchus who were seen at the Mayo Clinic during the 50 year period 1927 through 1977. Three forms of therapy were employed: complete surgical resection, radiation therapy alone, and radiation therapy after endoscopic removal of tumor tissue. Superior results were obtained in the group with adenoid cystic carcinoma, when complete resection was possible. Significant survival and palliation of sepsis was achieved with subtotal resection. The mucoepidermoid carcinomas in this series were classified on the basis of histologic differentiation. Mucoepidermoid carcinoma of Grade 1 was managed by conservative pulmonary resection. Mucoepidermoid carcinoma of Grades 2 and 3 showed a greater propensity for malignancy. Widespread dissemination caused death with unresectable high-grade mucoepidermoid carcinomas of Grades 2 and 3.
J Thorac Cardiovasc Surg 1978 Sep
PMID:Adenoid cystic carcinoma (cylindroma) and mucoepidermoid carcinoma of the bronchus. Factors affecting survival. 21 Mar 33

The mouse model of intraperitoneal enterobacterial sepsis was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. Single or multiple therapeutic doses of polymyxin, administered either before or after lethal challenge with Serratia marcescens, produced statistically and clinically significant protective effects.
Can J Microbiol 1979 Sep
PMID:Protective effect of polymyxin B sulfate in experimental enterobacterial infection in mice. 23 6

To study their value in predicting prognosis, tests were performed on peripheral blood lymphomononuclear cells and polymorphonuclear leukocytes in 34 critically ill patients with sepsis. Intially, the number of lymphomononuclear cells was reduced by 32% compared with healthy control subjects and was 42% lower in those who died than in survivors. The values remained low in those who died. The numbers of T and B cells, determined by rosette formation using sheep and mouse erythrocytes, did not change during the period of observation. Intially, K cell activity was decreased by 48% compared with normal activity. In those younger than 65 years, K cell activity was 68% lower in patients who later died than in survivors. It returned to normal at 20 to 30 days and decreased in those who died. Polymorphonuclear leukocyte adherence was decreased by 50% compared with healthy control subjects and tended to be lower in those who died. Chemotactic migration of polymorphonuclear leukocytes and intracellular killing of Staphylococcus aureus and Pseudomonas aeruginosa were not impaired. It was concluded that the lymphomononuclear cell count, K cell activity and adherence of polymorphonuclear leukocytes were decreased in patients with sepsis and that the values were useful in predicting prognosis.
Can J Surg 1979 Sep
PMID:Predictive value for survival of lymphocytes and polymorphonuclear leukocytes in patients with sepsis. 31 58

Hemorrhagic gastritis is the most frequent cause of upper gastrointestinal bleeding in patients with cancer. A study was undertaken to evaluate the clinical course of 87 patients, in a cancer hospital setting, with hemorrhagic gastritis associated with stress, exogenous gastric irritants and the combination of the two. The average number of blood transfusions was four times higher and the average duration of bleeding was twice as long in stress patients as in patients without stress. Fifty-four per cent of stress patients died, whereas all patients survived in the group without stress. Although there were no statistically significant differences, patients with the combination of gastric irritants and stress tended to bleed longer and have a higher mortality than patients with stress alone. Over two-thirds of the deaths were ascribed to associated stress risk factors such as sepsis, multiple organ failure and advanced cancer and not to gastrointestinal hemorrhage.
Am J Gastroenterol 1979 Sep
PMID:Risk factors and mortality in patients with cancer and hemorrhage from stress ulcer. 31 7

Acute intrinsic renal failure occurred in an adult patient with Escherichia coli septicemia. The clinical course did not include any of the circumstances usually present when acute renal failure complicates Gram-negative sepsis. A renal biopsy showed acute proliferative glomerulonephritis. There was no evidence to support other known causes of acute parenchymal renal failure, such as poststreptococcal glomerulonephritis, subacute bacterial endocarditis, or vasculitis. The patient recovered completely with antibiotic therapy, and renal function returned to normal within two weeks. An immunologic mechanism involving E coli was considered responsible for the acute renal failure.
JAMA 1977 Sep 26
PMID:Gram-negative sepsis with acute renal failure. Occurrence from acute glomerulonephritis. 33 Aug 92

In a case of septicemia and endarteritis the causative agent was initially misidentified. The Salmonella had atypical biochemical properties and was resistant to numerous antibiotics. Therapy with gentamicin and cephalothin failed to eliminate the organism. Identification of the organism as a lactose-fermenting Salmonella serotype typhimurium var. copenhagen was confirmed. The possible dissemination of the isolate from Brazil was analyzed by serologic studies of family members and friends.
Am J Clin Pathol 1977 Sep
PMID:Misdiagnosed Salmonella septicemia and endarteritis due to a lactose-fermenting strain: bacteriologic and epidemiologic considerations. 33 39

The results of operative treatment of thirty-six patients with acute gastric mucosal hemorrhage are presented. Alcohol and surgery/trauma were the most frequent causes, and renal failure, sepsis, or multisystem disease caused most deaths; overall mortality was 44 per cent. Vagotomy-pyloroplasty and vagotomy-resection are compared, and no statistically significant difference in rebleeding, reoperation for bleeding, or mortality is identified.
Am J Surg 1977 Sep
PMID:Choice of operation for acute gastric mucosal hemorrhage. Report of 36 cases and review of literature. 33 75

Twenty Holstein-Friesian male calves were obtained within 4 hours after bith (colostrum deprived) and allotted to 1 of 4 groups, each given a different feeding: colostrum, milk replacer, polyvinylpyrrolidone (PVP), and saline solution (0.85% NaCl). Each calf was fed 2 L of the respective diets every 12 hours. Rectal temperatures were recorded and blood samples were collected immediately before each feeding. At approximately 27 hours of age, all calves were inoculated orally with 1.5 X 10(10) viable organisms of a septicemia-producing Escherichia coli serotype O26: K60:NM. Within 8 hours, all calves had diarrhea. Coli-septicemia (E coli cultured from liver, spleen, and cardiac blood) was present in 1 of the 5 calves fed colostrum, in 5 or the 5 calves fed milk replacer, in 5 of the 5 calves fed PVP, and in 4 of the 5 calves fed saline solution. At necropsy of the calves (12 to 48 hours after oral inoculation), the same organism was isolated by cultural technique from small intestines of 19 of the 20 calves. Serum immunoglobulin G concentrations increased (P less than 0.01) in calves fed the colostrum diet in sharp contrast to the agammaglobulinemia occurring in calves fed the milk replacer, PVP, or saline solution. Results indicate that colostrum fed to the calf soon after birth provides protection from colisepticemia, but does not prevent the diarrhea of colibacillosis.
Am J Vet Res 1977 Sep
PMID:Resistance of neonatal calves given colostrum diet to oral challenge with a septicemia-producing Escherichia coli. 33 27


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