Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036690 (
sepsis
)
59,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Potassium (K
+
) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K
+
channel (K
2P
)
TWIK2
as the K
+
efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding
TWIK2
) prevented NLRP3 activation in macrophages and suppressed
sepsis
-induced lung inflammation. Adoptive transfer of Kcnk6
-/-
macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K
+
efflux channel
TWIK2
in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to
TWIK2
as a potential target for anti-inflammatory therapies.
...
PMID:The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. 2995 99
