Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036690 (
sepsis
)
59,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Twelve patients with malignant melanoma metastatic to the central nervous system (CNS) were treated with
PCNU
. All patients had prior chemotherapy and/or radiation therapy and had progressive brain metastases, documented by computerized tomography.
PCNU
was given as a single intravenous infusion of 90-110 mg/m2 every 6-8 weeks. There was one partial response and four patients had stable disease. Although no episodes of
sepsis
or bleeding occurred, seven of 17 courses led to significant granulocytopenia or thrombocytopenia. Nonhematopoietic toxicities were mild. These results indicate that systemic
PCNU
is unlikely to be more effective than other currently used chemotherapy in patients with malignant melanoma and CNS metastases.
...
PMID:A phase II trial of PCNU in patients with malignant melanoma and central nervous system metastases. 405 Jul 40
