Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036690 (
sepsis
)
59,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Septic shock has an extremely high mortality rate, with approximately 200,000 people dying from
sepsis
annually in the U.S. The high mortality results in part from severe hypotension secondary to high serum NO concentrations. Reducing NO levels should be beneficial in
sepsis
, but NOS inhibitors have had a checkered history in animal models, and one such agent increased mortality in a clinical trial. An alternative approach to reduce NO levels in
sepsis
is to use an NO scavenger, which should leave sufficient free NO for normal physiological functions. Using a well-established model of bacterial
sepsis
in Drosophila melanogaster, we found that cobinamide, a B(12) analog and an effective NO scavenger in vitro, dramatically improved fly survival.
Cobinamide
augmented the effect of an antibiotic and was beneficial even in immune-deficient flies.
Cobinamide
's mechanism of action appeared to be from reducing NO levels and improving cardiac function.
...
PMID:The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. 1694 Jan 58
