Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During 1985 and December 1990 children referred to hospitals with HIV infection were subjected to a protocol previously established to determine HIV antibodies by ELISA and Western Blot methods. Children under 15 months of age underwent repeated tests to preclude the transfer of maternal antibodies. In this group only children with more than 6 months of follow-up were included. 17 cases were studied: 6 were children under 15 months of age, 8 were between 15 months and 5 years, and 3 were between 5 years and 15 years. 12 children originated from urban areas, 3 from rural areas, and 2 were foreigners. The clinical symptoms started in the first year of life in 8 cases, between 1 and 3 years in 7 cases, and after 5 years of age in 2 cases. HIV transmission was vertical in 8 cases, via blood transfusion in 2 cases, and in 7 cases the route of transmission could not be confirmed. The follow-up lasted 6 months for 5 cases; 18 months for 5 cases; 2 years for 4 cases; and 3.5 years for 3 cases. The clinical signs were predominantly: cutaneous lesions in 10 of the 17 cases, diarrheal disease in 7, fever in 6, malnutrition in 6, as well as hypertrophy, oral moniliasis, sepsis, esophageal candidiasis, otitis, and varicella in different patients. According to CDC classification, 9 cases corresponded to class P-1 (one of them with elevated immune function and the other with normal immune function); 6 corresponded to pediatric class P-2 (2 to subclass A, 2 to subclass D, and 2 to subclass D-2). 6 children died: 4 due to meningitis and sepsis, 1 due to varicella, and 1 due to malnutrition, sepsis, and esophageal candidiasis.
Arch Domin Pediatr
PMID:[Pediatric AIDS: characteristics of 17 Dominican cases]. 1234 59

The archives of the blood bank of the hospital of Dr. Louis Manual Morillo King, in the city of La Vega, Dominican Republic, were reviewed to identify all children who had been given blood transfusion during the period of July 1983 to July 1987 in order to identify HIV and the surface antigen of hepatitis B (HBsAg). Those who were released were visited in their homes for administration of HIV and hepatitis tests. Positive tests were confirmed by another test (AUSYME MONOCLONAL and Western Blot). Mothers were also tested to detect vertical transmission. 256 patients had been transfused, of whom 61 died. 80 of the 195 remaining patients could not be located. Of the 115 patients located, 52 had died in their homes after release from the hospital. Thus, the sample comprised 63 patients: 36 were 0-3 years old, 21 were 4-7 years old, and 6 were 8-11 years old. 50 lived in rural and 13 in urban areas. 56 patients had one transfusion and 4 had two transfusions. 28 patients had transfusion for anemia, 19 for malnutrition, 7 for sepsis, 6 for various reasons (meningitis, pleuritis, pneumonia), and 3 for sickle cell disease. 47 patients had been transfused at the hospital using the blood bank, 13 used blood from relatives, and 3 received blood from friends. Out of the 63 samples processed, 2 patients presented seropositivity for hepatitis B, while none were seropositive for HIV. Among the 2 patients who were seropositive for hepatitis B, the mother of one of them was also seropositive.
Arch Domin Pediatr
PMID:[Human immunodeficiency virus and hepatitis B virus in children transfused in the Dr. Luis Manuel Morillo King Hospital]. 1234 60

Measles is caused by a virus which exclusively affects humans. Erroneously it has been considered benign, although it causes high morbidity and mortality because of the complications it precipitates. The Expanded Program of Immunization estimated that 1.5 million children in the world die every year because of measles. The objective was to analyze the incidence of measles and complicated measles in children who had been admitted to Dr. Robert Reid Cabral Pediatric Clinic, Santo Domingo, Dominican Republic, during the period of January 1991 to January 1992. A total of 311 patients were enrolled with the diagnosis of measles during the 13 months of the study, with an average of 24 cases per month. October and December were the months when most patients presented with measles: respectively, 56 (18%) and 60 (19.4%) patients of the total caseload. Pneumonia was the most frequent complication with 277 cases (87.1%), followed by acute diarrheal disease with 25 cases (8.0%). The most affected was the 1-3 year age group with 143 patients (46.0%). In 135 cases (43.4%) the children with measles had not been vaccinated; only 72 patients (23.3%) had received vaccination. Furthermore, 104 patients (33.3%) did not know their vaccination history. 170 patients (54.7%) were malnourished. During the study period 37 children (11.9%) died in the hospital and 24 of these children (64.9%) died as a result of the complication of pneumonia. Other causes of death were: laryngotracheitis (4), encephalitis (3), subcutaneous emphysema (4), and septicemia (2). This investigation showed that pneumonia is a very grave complication in malnourished children and in children under one year of age.
Arch Domin Pediatr
PMID:[Incidence of measles with complications]. 1234 61