Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A normally fit European resident of East Africa developed a staphylococcal peri-nephric abscess following repeated episodes of furuncular myiasis caused by the tumbu fly, Cordylobia anthropophaga. A few lesions had required surgical intervention and one, presumably the source of sepsis, had become infected. There are very few descriptions in the literature of serious complications of myiasis and this is the first report of peri-nephric abscess from this source. This paper discusses the management of the myiasis and what factors determine the variation in host susceptibility and immune response to the infestation.
Clin Exp Dermatol 1995 May
PMID:Troublesome myiasis complicated by peri-nephric abscess. 767 23

Toxic epidermal necrolysis (TEN) is a rare condition in childhood usually attributed to drugs. We describe a 4-month-old infant who developed typical clinical and histologic findings of TEN concomitantly with Klebsiella pneumoniae sepsis. We emphasize that in cases of acute, severe exfoliative disease in infants, apart from staphylococcal infection, gram-negative bacterial sepsis must also be considered.
Pediatr Dermatol 1994 Dec
PMID:Toxic epidermal necrolysis associated with Klebsiella pneumoniae sepsis. 789 84

The records of 10 patients who died with pemphigus have been examined for factors affecting and contributing to death. Early initiation of therapy, the age at onset of the disease, and the mode of administration of corticosteroids, conventional or in pulse form, did not affect the survival. The cutaneous involvement was extensive in all 10 patients; it ranged between 30-80%. Septicemia was the commonest event preceding death; in 4 cases, it was due to Staphylococcus aureus.
J Dermatol 1994 Sep
PMID:Factors responsible for death in patients with pemphigus. 796 69

We report a case of follicular keratosis with inflammatory changes, consistent with a diagnosis of atypical juvenile pityriasis rubra pilaris. An unusual feature was the occurrence of severe Staphylococcus aureus folliculitis and furunculosis, a phenomenon rarely encountered in pityriasis rubra pilaris and the other follicular keratoses. Standard antibiotic and antiseptic treatment for chronic S. aureus infection was ineffective. The patient was subsequently found to have hypogammaglobulinaemia, and treatment with human polyvalent immunoglobulin infusions was successful in eradicating the sepsis. It is therefore probable that the hypogammaglobulinaemia played a pathogenic role in the development of cutaneous sepsis.
Br J Dermatol 1994 Nov
PMID:Juvenile pityriasis rubra pilaris associated with hypogammaglobulinaemia and furunculosis. 799 8

A 58-year-old man with diabetes had fever and chills 5 days after ingestion of raw seafood. Nausea, vomiting, watery diarrhea, bilateral calf pain, and neck stiffness subsequently developed. Generalized edema and ecchymotic patches with a vesiculobullous eruption appeared on the extremities. Four blood cultures were positive for Vibrio cholerae non-01. The patient was successfully treated with antibiotics. This is the first documented case of V. cholerae non-01 septicemia with cutaneous lesions and meningitis in Taiwan.
J Am Acad Dermatol 1994 Apr
PMID:Cutaneous manifestations of non-01 Vibrio cholerae septicemia with gastroenteritis and meningitis. 815 89

Purpura fulminans is a rare syndrome of progressive hemorrhagic necrosis of the skin that may present as a dermatologic emergency. It most commonly affects children during the convalescent phase of a streptococcal infection or a viral exanthem. In adults, it may be associated with sepsis or acquired causes. Its pathogenesis has challenged physicians for decades. It has been discovered that purpura fulminans is almost always associated with disseminated intravascular coagulation and can occur in subjects with inherited or acquired deficiencies of the protein C anticoagulant pathway. Patients with liver compromise may also be potential candidates for coagulopathies secondary to hepatic dysfunction and impaired protein synthesis. It is widely recognized that individuals who consume alcohol on a long-term basis may develop severe hepatotoxicity from ingestion of therapeutic doses of acetaminophen (500 to 1000 mg every 4 to 6 hours). We have observed a patient with chronic alcoholism in whom hepatotoxicity and purpura fulminans developed secondary to the ingestion of acetaminophen.
Arch Dermatol 1993 Oct
PMID:Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K. 821 90

Bullous lesions associated with non-01 Vibrio cholerae developed in a patient with hepatic cirrhosis who had recently ingested raw oysters. He died of overwhelming sepsis despite 5 days of aggressive antibiotic therapy. Non-01 V. cholerae was isolated from blood, peritoneal fluid, and bullae. The organism produced a cytotoxic factor that destroyed Chinese hamster ovary cells. Although septicemia caused by non-01 V. cholerae is uncommon, cutaneous manifestations of this organism are even rarer. Our patient represents the first reported case of bullous lesions associated with non-01 V. cholerae septicemia.
J Am Acad Dermatol 1993 Nov
PMID:Fatal septicemia and bullae caused by non-01 Vibrio cholerae. 840 40

We describe three neonates who had large eroded areas of skin on their extremities. The clinical course and ultrastructural findings were consistent with a diagnosis of epidermolysis bullosa herpetiformis (Dowling-Meara type). In each case blisters developed around eroded areas after birth and enlarged centrifugally in a herpetiform fashion. One patient died of sepsis at 8 days of age. In the two survivors blister formation subsided gradually within 1 year. Ultrastructural studies confirmed intraepidermal blister formation associated with spheric aggregates of tonofilaments in the lower epidermis. Spheric aggregates were also found in clinically uninvolved skin.
J Am Acad Dermatol 1993 May
PMID:Three neonatal cases of epidermolysis bullosa herpetiformis (Dowling-Meara type) with severe erosive skin lesions. 849 81

During 1982-1992, physicians at the Johannesburg General hospital in South Africa treated 49 patients aged 23-59 with biopsy-confirmed Kaposi's sarcoma (KS). Single chemotherapeutic agents used included vinblastine, actinomycin D, bleomycin, and vincristine. Most combined regimens used included doxorubicin/vincristine/bleomycin or etoposide/methotrexate. 17 patients, all of whom were men, had endemic African KS (AKS). 32 patients had AIDS-related KS. 58% of AKS patients experienced partial remission. 23% experienced complete remission compared to none of the patients with AIDS-related KS. 19% of AKS patients experienced complete treatment failure and died quickly. Deteriorating performance status or debilitating side effects (e.g., severe mucositis and neutropenic sepsis) necessitated completion of therapy in most patients with AIDS-related KS. Opportunistic infections claimed the lives of many patients with AIDS-related KS. Any response to therapy among AIDS-related KS patients was of short duration. These findings indicate that AKS responds to chemotherapy, while AIDS-related KS does not. In fact, AIDS-related KS has a poor prognosis.
Int J Dermatol 1995 Oct
PMID:Chemotherapy for AIDS-related and endemic African Kaposi's sarcoma in southern Africa. 853 66

We report a patient with severe epidermolysis bullosa acquisita (EBA) whose disease was refractory to conventional treatments. New bullae continued to develop over greater than 50% of his body surface area despite therapy. His course was complicated by hyperglycaemia, sepsis, hypoxia caused by pulmonary Aspergillus infection and an idiopathic cardiomyopathy. His EBA resolved after treatment with extracorporeal photochemotherapy (ECP). Hence, ECP may be effective in the treatment of severe EBA which has failed to respond to standard treatment regimens.
Br J Dermatol 1995 Sep
PMID:Remission of severe epidermolysis bullosa acquisita induced by extracorporeal photochemotherapy. 854 7


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