Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multiple system failure is often the final result of severe infection that cannot be controlled. The changes that may occur in remote organs and cells in the early stages of sepsis and that may initiate this process have not been defined. To study this, indocyanine green (ICG) clearance, serum enzyme levels, and reticuloendothelial (RE) function were measured during various stages of sepsis, which was produced in rats by cecal ligation and puncture (CLP). The clearance of ICG decreased significantly during the early stages of sepsis (five hours after CLP) at a time when there was no change in the serum enzyme levels or RE function. Ten hours after CLP, RE function was depressed, and serum enzyme levels were elevated. Progressive changes in RE function and serum enzyme levels occurred in the late stages of sepsis (16 hours after CLP). Since unaltered hepatic adenosine triphosphate levels have been previously found, even ten hours after CLP, humoral factor(s) may be responsible for altered ICG clearance in the early stages of sepsis. Thus, hepatocellular dysfunction occurred early in the course of sepsis and was manifested by a deficit in a plasma membrane active transport process (ICG clearance). Indocyanine green clearance provided an extremely sensitive early indication of a hepatic abnormality.
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PMID:Altered hepatocellular active transport. An early change in peritonitis. 705 32

Indocyanine green clearance (Cl-ICG) has been used to assess liver function and hepatic blood flow mainly before and after hepatic surgery. Cl-ICG (invasive method) has been reported to be a good marker of early graft function after liver transplantation (LT). The goal of this study was to determine if the indocyanine green plasma disappearance rate (PDR-ICG), measured by a noninvasive technique (LiMON, Impulse Medical System, Munich, Germany), is predictive of complications and graft outcome after LT. From September 2005 to June 2006, 72 LT recipients were included in the study. PDR-ICG was measured daily (from day 0 to day 5 after LT) with a digital sensor after patients were injected with 0.25 mg/kg indocyanine green. A PDR-ICG cutoff level of 12.85%/minute was predictive of the development of a serious postoperative complication. The sequential changes of PDR-ICG enabled us to differentiate 2 groups: (1) patients with early severe complications (hepatic artery thrombosis, primary graft nonfunction, or sepsis) who had a low value of PDR-ICG during the first 5 posttransplantation days (average, 8.8 +/- 4.5%/minute) and (2) patients who developed acute rejection and who had a progressive reduction of PDR-ICG between days 0 and 5 (from 25.5 +/- 4.8 to 10.3 +/- 2.5%/minute; P < 0.002). In conclusion, after LT, PDR-ICG (a noninvasive technique), measured regularly during the first 5 postoperative days, is a safe technique that can predict early postoperative complications.
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PMID:Plasma disappearance rate of indocyanine green: a tool to evaluate early graft outcome after liver transplantation. 2051 18

Indocyanine green (ICG) is a water-soluble dye that is bound to plasma proteins when administered intravenously and nearly completely eliminated from the blood by the liver. ICG elimination depends on hepatic blood flow, hepatocellular function and biliary excretion. ICG elimination is considered as a useful dynamic test describing liver function and perfusion in the perioperative setting, i.e., in liver surgery and transplantation, as well as in critically ill patients. ICG plasma disappearance rate (ICG-PDR) which can be measured today by transcutaneous systems at the bedside is a valuable method for dynamic assessment of liver function and perfusion, and is regarded as a valuable prognostic tool in predicting survival of critically ill patients, presenting with sepsis, ARDS or acute liver failure.
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PMID:Assessment of liver perfusion and function by indocyanine green in the perioperative setting and in critically ill patients. 2924 95