Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Laboratory studies of CFX were performed on susceptibility of 123 strains isolated from 72 patients with septicemia by disc sensitivity method in comparison with CER and ABPC. Antibacterial activity of CFX was superior against Escherichia coli, Klebsiella, Serratia marcescens and Proteus than that of CER and ABPC, especially against Serratia marcescens and Bacteroides which were mostly resistant to CER and ABPC. CFX was administrated to 8 patients with septicemia. Clinical effects were obtained, excellent and good in 5 patients and poor in 3, and effective rate was 63%. No side effects were observed. The above results indicate that CFX is mainly useful in the treatment of infections caused by Gram-negative bacilli, especially resistant to penicillins, cephalosporins, and Bacteroides.
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PMID:[Clinical studies of cefoxitin for the treatment of septicemia (author's transl)]. 732 52

Many clinical experiments and studies have demonstrated that traditional Chinese medicines possess the capacity for being used in anti-sepsis. In this paper, we screened 78 herbs based on biosensor technology by targeting of lipid A. Terminaliachebula Retz was found to possess the highest capability of binding lipid A. With CER (cation-exchange resin) and HPLC, we obtained three active components extracted from Terminaliachebula Retz, and named them TCR1, TCR2 and TCR3 respectively. These three components were evaluated with the biosensor, and it was found that the TCR3 was the most capable candidate to bind lipid A. We also studied the biological activities of TCR3 against sepsis in vitro and in vivo. in vitro, TCR3 could significantly inhibit LPS (lipopolysaccharide)-induced LAL (Limulus amoebocyte lysate)) from agglutination and decrease TNFalpha (tumour necrosis factor alpha) release from RAW264.7 cells induced by LPS in a dose-dependent manner. in vivo, TCR3 could significantly protect mice against a lethal challenge with LPS and heat-killed Escherichia coli 35218 in a dose-dependent manner. These results demonstrate that Terminaliachebula Retz is an important herb to neutralize LPS and it has the potential to serve as a treatment for sepsis.
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PMID:Extraction of the anti-sepsis component from Terminaliachebula Retz and evaluation of its biological activities. 1920 50