Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The term neonatal or infantile erythroderma designates a generalized erythema covering more than 90% of the body surface area of neonates and young infants. Erythrodermas are not rare in this age group and have been associated with more than 40 diseases of different degrees of severity. Regardless of the underlying illness, impending acute symptoms of an impaired epidermal barrier function (hypothermia, dehydration, sepsis) must be recognized and treated adequately. Most often patients have to be hospitalized for incubator care and, if necessary, intravenous rehydration and antibiotic therapy. Later a thorough diagnostic workup should be performed in cooperation with specialized centers in order to guarantee a precise diagnosis and the most effective treatment. In particular, potentially severe extracutaneous symptoms require rapid intervention and represent the main focus of this review.
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PMID:Neonatal and infantile erythrodermas. 1913 73

Generalized pustular psoriasis (GPP) is an immune-mediated dermatologic condition that is characterized by a widespread eruption of sterile, subcorneal pustules. Cases of GPP may present to the burn intensive care unit (ICU), and they may be confused with toxic epidermal necrolysis (TEN) due to the generalized erythema and desquamation. GPP often benefits from admission to an ICU for management of fluid and electrolyte imbalances and for complications such as pneumonitis, renal dysfunction and sepsis. We present the case of a 42 year-old man who was transferred to the burn unit for presumed TEN where he was diagnosed with GPP and successfully treated with intravenous cyclosporine and supportive care. Our objective is to increase awareness of this condition in the critical care community, discuss clinical and laboratory findings, and to review the treatment guidelines published by the National Psoriasis Foundation in August 2012. We also discuss the latest reports utilizing biological response modifying drugs.
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PMID:Acute generalized pustular psoriasis, von Zumbusch type, treated in the burn unit. A review of clinical features and new therapeutics. 2449 19