Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Extra-anatomic bypass of the abdominal aorta was performed in 25 patients too ill to undergo abdominal operation (Group I) and in 22 patients with graft sepsis or hemorrhage (Group II). The graft patency rate determined by life table analysis in Group I patients was 83.5% at one year and 60% at two years. The graft patency rate for Group II patients of 47% at one year was significantly lower than the patency rate for Group I patients (p <.01). Thrombectomy was attempted in 11 of the 18 grafts that occluded postoperatively. Patency was re-established by this method in nine grafts (82%), failures resulted in amputation. Recurrent occlusion of three thrombectomized grafts was treated by multiple thrombectomies with cumulative patencies up to 44.5 months. Thrombectomy was not attempted in seven occluded grafts. Two graft occlusions resulted in amputation of extremities. Contralateral axillofemoral grafts were performed in three of the patients, ipsilateral axillofemoral graft in one patient, and aortobifemoral graft in one patient. Thrombectomy is the treatment of choice for occluded extra-anatomic bypass grafts. It can be performed easily under local anesthesia. If unsuccessful, contralateral axillofemoral or femoro-femoral grafts are indicated to re-establish blood flow.
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PMID:Extra-anatomic bypass of the abdominal aorta: management of postoperative thrombosis. 64 5

The origin, background, and mechanism of operation of the Maternal Mortality Study Committee in Wisconsin is outlined. Its value as a teaching vehicle is emphasized. Trends in maternal mortality in Wisconsin and the continued decline are presented, with 45 per 100,000 live births in 1953 to 9.2 per 100,000 live births in 1975. An appeal for standardization of terms and definitions and a continuation of these studies in each state is made. Study committees in many states are inactive. It is suggested that chairmen of maternal mortality committees in many states are inactive. It is suggested that chairmen of maternal mortality committees and representatives meet in geographic areas comparable to Districts of The American College of Obstetricians and Gynecologists to compare trends and statistics. Hemorrhage, once considered the important cause, has decreased from 56.4% of maternal loss to a low of 12.1% in 1975. Presently, a category listed as "other causes"--that is, other than hemorrhage, sepsis, and toxemia--account for approximately 60% of deaths. This group includes anesthesia, emboli and coincidental disease involving kidneys, heart, malignancy, and diabetes. An appeal is made to continue these studies.
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PMID:Mothers are still mortal. 70 97

The effect of anesthesia and operation on immunity measured by leukocyte migration inhibition using streptokinase-streptodornase is reported in normal patients undergoing elective surgical procedures. Eight-five per cent of the patients exhibited postoperative immunosuppression, and this persisted for 60 days or longer in more than half of them. Despite this, no complication was encountered relating to wound healing or sepsis.
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PMID:Perioperative suppression of the leukocyte migration inhibition assay in patients undergoing elective operations. 71 49

Dogs were subjected to tracheostomy and intubation with low pressure cuffed tracheostomy tubes. Various mixtures of bile, gastric secretion and 0-1 N Hydrochloric acid were injected into the trachea via a small catheter attached to the main tracheostomy cannula to simulate the effect of aspirated gastric contents. Bronchoscopic observations were made during the study to investigate the local effects of secretions pooling above the cuff, in contact with the tracheal wall. Gross pathological changes were observed when the animals were sacrificed at the end of the study. The constituents of a mixture of bile and gastric juice increased the severity of tracheal damage due to mechanical trauma and sepsis. Healing was delayed and the reparative process was abnormal. This experimental study indicates that the combination of bile and acid pepsin reaching the tracheal wall may also be a major factor which predisposes to the development of early and late tracheal injury.
Anaesthesia
PMID:Tracheal damage associated with cuffed tracheostomy tubes. Aspiration of gastric content as a cause of local damage in tracheotomised dogs. 90 Apr 35

The authors examined 2642 cases of mastitis in the course of 5 years. 2 of the patients died of sepsis. Acute lactation mastitis may be divided into several categories. The various kinds of lactation mastitis are examined. The treatment of mastitis is always associated with dietotherapy prescribed in case of acute infectious mastitis by a massive vitamin-therapy and by therapy under anesthesia when necessary. The administration of aspirin is nowadays considered as a mistake because of its teratogenic effects. Prophylactic measures may be applied in order to reduce the frequency of lactation mastitis.
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PMID:[Lactation mastitis]. 101 46

Anesthetic-induced immunosuppression, if clinically significant, could modify the natural course of infectious disease in vivo. To test this bypothesis, the localized response to IM Candida albicans and the mortality following fecal peritonitis were examined in anesthetized mice. Using these 2 models, halothane anesthesia was found not to modify the natural history of local sepsis but to significantly accentuate the mortality associated with the more severe infection. Possible explanations for these results include significant inhibition of reticuloendothelial function or plasma opsonization with relatively minor derangements of peripheral leukocyte capability.
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PMID:Anesthesia and the modification of response to infection in mice. 103 91

The pre- and intra-operative care of patients with acute intestinal obstruction is reviewed. The most important pre-operative problems are hypovolaemia, sepsis, electrolyte and acid-base imbalances. The evaulation and treatment of these disorders are discussed. The importance of preventing regurgitation and inhalation of stomach contents is emphasised and the methods which are used are described. The safest techniques of induction and maintenance of anaesthesia as well as muscle relaxation and intra-operative fluid therapy are indicated.
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PMID:[Anesthesia for patients with intestinal obstruction]. 115 44

Based on a knowledge of electropathophysiology, a recommended treatment has been proposed for the management of extensive high-voltage electrical burns. Early, aggressive, surgical intervention consisting of adequate decompression fasciotomy and wound debridement has been emphasized as the first line of treatment. Frequent redebridements under general anesthesia are important to the preservation of viable tissue. Early coverage procedures or attempts at primary closure following decompression are contraindicated in high-voltage injuries. This method of treatment in eight cases of high-voltage, electrical injury has preserved viable tissue, decreased the incidence of fatal sepsis and renal shutdown, decreased patient morbidity, and generally facilitated patient rehabilitation.
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PMID:Early decompression fasciotomy in the treatment of high-voltage electrical burns of the extremities. 116 23

Prolapsed pedunculated leiomyomas of the uterus can best be managed by simple vaginal myomectomy. It is safe, easily performed and generally requires no anesthesia. The risk of complications during and after a major abdominal surgical procedure in the face of infection and anemia is eliminated. Interval hysterectomy, if indicated, may be done four to six weeks after vaginal myomectomy without incurring the additional risk of increased operative morbidity. Additional surgical procedures are not indicated if the pelvic examination remains normal. When large leiomyomas are encountered, the pedicle may not be accessible. Confronted with such a situation and continued blood loss and sepsis, we elected in three patients to replace the tumor within the endometrial cavity and close the cervix. Immediate hysterectomy was then carried out. Blood replacementd antibiotic coverage were instituted in advance of any operative procedure. Other pathologic entities must be kept in mind as a source of uterine bleeding that may be found in association with pedunculated myomas.
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PMID:The surgical management of prolapsed pedunculated submucous leiomyomas. 116 67

Hospital and anesthesia records of 39 patients who had hepatic artery ligation for severe hepatic trauma were analyzed retrospectively to acquire information on any relationships between choice of anesthetic, preoperative physical condition of the patient, type and incidence of complications, and mortality. Patients who had lost the most blood received neuroleptanalgesia, ketamine, or cyclopropane; those with more stable cardiovascular status received halothane; those in severe circulatory compromise received only oxygen and muscle relaxants. Trends in results of postoperative liver function tests were not related to type of anesthesia. Of the 12 deaths, seven were due to massive bleeding, three to septicemia, one to multiple complications, and one to hepatorenal failure 18 days postoperatively. Choice of anesthetic agent appeared to have no significant influence on postoperative morbidity and mortality; rather, the choice of anesthesia depended on the preoperative physical (especially hemodynamic) status of the patient, which in turn reflected the apparent blood loss estimated at induction.
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PMID:Anesthesia and hepatic artery ligation. 125 Dec 34


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