Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Impetigo herpetiformis or gestational pustular psoriasis can account for 4.25% of all pregnancy dermatoses seen. Unlike other pregnancy dermatoses, it can be associated with constitutional symptoms including fever, rigors, arthralgia and complications of secondary infection and sepsis. There is an increased risk of fetal anomalies and stillbirths. A 25-year-old para 1 presented to primary care at 7 weeks gestation with a peri-umbilical rash non-responsive to topical steroids and underwent hospital admission at 31 weeks gestation with fever and a widespread painful erythematous rash. Her condition worsened despite high-dose oral steroids. With the use of cyclosporine and regular opioid analgesia over 2 weeks, her symptoms were adequately controlled. She went into spontaneous labour at 41(+2) weeks and delivered a healthy male infant. Impetigo herpetiformis can be treated first line with topical and oral steroids and supportive measures, but immunomodulatory therapies such as cyclosporine have shown success in treating resistant cases.
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PMID:First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. 2269 29

Impetigo herpetiformis (IH), or generalized pustular psoriasis of pregnancy, is an exceedingly rare, generalized pustular skin eruption occurring during pregnancy associated with hypovolemia, sepsis, hypocalcemia, and airway edema. Fetal outcomes are generally poor, and parturients with IH may present with emergent indications for cesarean delivery due to placental insufficiency. We present a case of IH in a 19-year-old G1P0 who underwent successful general anesthesia for cesarean delivery. Her case highlights the anesthetic implications for patients afflicted with this rare disease, including perioperative pain management, airway concerns, considerations for neuraxial anesthesia, and monitoring challenges.
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PMID:Anesthetic management for cesarean delivery of a parturient with impetigo herpetiformis. 2561 5