Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During 1980-1984, 51 patients with enteric fever (typhoid/paratyphoid fever and salmonellosis) biliary tract sepsis, and other Gram-negative infections were treated with temocillin at 3 medical centres in Bangkok, Thailand. This article summarises the results in the 42 evaluable patients (14 males, 28 females); 10 patients with enteric fever, 2 patients with salmonellosis; 12 patients with biliary tract sepsis, and 18 patients with other Gram-negative infections. Overall, 86% of the patients were clinically cured or improved. Bacteriological eradication or marked reduction in the number of organisms was achieved in 95% of the patients. In 10 cases of enteric fever and 2 cases of salmonellosis all bacterial pathogens were eradicated, but 1 case of Salmonella paratyphi infection failed clinically. Eleven of 12 biliary tract infections were clinically cured or improved, and organisms were eliminated from all 10 bacteriologically assessable patients. The majority of patients received 1 to 2g of temocillin given by intravenous infusion twice daily for 5 to 14 days. Temocillin was well tolerated by all patients.
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PMID:Use of temocillin in typhoid fever, hepatobiliary disease and other infections. 392 21

An HIV-infected 49-year-old man was admitted with polyuria, fever, chills and a dull left lumbar pain. Laboratory tests showed increased C-reactive protein while urine analysis and abdomen ultrasound scan were negative. Blood cultures revealed a Salmonella paratyphi B, identified through MALDI-TOF mass spectrometry. Targeted antibiotic therapy with intravenous piperacillin/tazobactam was started and a multi-phase contrast-enhanced abdomen CT-scan was performed at 24 hours from admission showing a saccular aneurysm of the abdominal aorta with a 1 cm penetrating aortic ulcer on posterior wall. The patient underwent emergency vascular surgery at 34 hours from admission for debridement and homo-graft placement of sub-renal aorta, and surgical samples were sent for microbiological analysis. Unfortunately, the patient died on post-surgical day 7 after haemorrhagic shock due to laceration of his graft. Salmonella paratyphi infection can be responsible for sepsis in severely immunosuppressed patients with poorly controlled HIV, requiring careful work-up for cardiovascular involvement.
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PMID:Salmonella paratyphi B mycotic aneurysm of the abdominal aorta in an HIV-infected patient: a case report. 2611 Feb 99