Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

alpha 2-macroglobulin is probably the most important of the antiproteases in plasma. In this study, the relationships of plasma alpha 2-macroglobulin to the clinical features of acute pancreatitis as well as to plasma levels of other antiproteases, immunoglobulins, and immunoreactive trypsin, were investigated in 55 patients with acute pancreatitis. The mean level of alpha 2-macroglobulin in 395 plasma samples from the patients was 2.12 g/liter compared with 2.41 g/liter in 29 healthy subjects and 2.93 g/liter in 17 patients with septicemia. Plasma levels were lower in 12 patients with severe pancreatitis than in 43 with mild attacks, and the lowest levels in three fatal attacks were less than half the mean of the normal range. Lowest levels were recorded at a mean time of 3 days after admission in the patients with mild attacks, at 5 days after admission in the patients with severe attacks, and 9 days after admission in those with fatal attacks. In contrast, plasma levels of the alpha 1-proteinase inhibitor antichymotrypsin and C-reactive protein increased to above normal levels during the attack, significantly more so in severe compared with mild attacks. Plasma levels of IgA, IgG, and IgM remained within the normal range or were increased. In patients with severe pancreatitis, plasma levels of immunoreactive trypsin remained elevated for longer than in those with mild attacks although there was little initial difference in the levels. These data suggest that decreasing levels of alpha 2-macroglobulin during the course of acute pancreatitis are due to a specific mechanism and unrelated, for the most part, to any generalized effect of pancreatitis on protein synthesis. The formation of rapidly cleared complexes between alpha 2-macroglobulin and active proteases is the most tenable explanation for the depletion of plasma levels, but the clinical significance of the changes remains unclear.
 ...
PMID:Relation of alpha 2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis. 619 93

Serum lactoferrin concentrations were elevated in 22 out of 49 newborn infants with suspected and verified severe bacterial as well as viral infections, suggesting that this protein resembled an acute phase reactant. In the infants suspected of having septicemia, high concentrations of C-reactive protein appeared to indicate a severe bacterial infection. Like lactoferrin, however, haptoglobin, orosomucoid, alpha 1-antitrypsin and alpha 1-antichymotrypsin discriminated only poorly or not at all between infants with severe bacterial infections and those in which such infections were unlikely. Thus, serum CRP concentrations remained the most valuable of the acute phase reactants tested as an aid in ruling out septicemia in the neonatal period.
 ...
PMID:Lactoferrin in relation to acute phase proteins in sera from newborn infants with severe infections. 620 65

The simultaneous changes in serum prealbumin, orosomucoid (alpha-acidglycoprotein, AGP), and C-reactive protein (CRP) were evaluated in 36 newborn infants with septicemia (n = 20), meningitis (n = 10), arthritis (n = 5), and peritonitis (n = 1). In 29 patients with a favorable outcome the values for serum prealbumin and CRP showed a rapid return toward normal: in 2 to 3 days serum prealbumin increased by 84% from the basal value and remained at (mean +/- 1 SD) 0.11 +/- 0.02 gm/L. Serum CRP decreased from 85 +/- 75 mg/L (range 0.15 to 206 mg/L) to 49 +/- 64 mg/L (2 to 210 mg/L) at 3 to 4 days of evolution and to normal values at day 13 to 16. The changes in serum orosomucoid values were slower, from 1.33 +/- 0.75 gm/L to 1.16 +/- 0.75 gm/L at day 13 to 16, with normalization after 20 to 30 days. Serum orosomucoid values returned to the normal range with the clinical improvement. In some patients the orosomucoid/prealbumin ratio decreased earlier than the serum orosomucoid concentration. Seven patients died, and in four of these in whom at least three values could be determined serum CRP and orosomucoid remained very high, whereas serum prealbumin did not increase or subsequently decreased. These data show an inverse change in serum CRP and prealbumin concentrations in infected neonates. The immediate decrease in CRP reflects the effect of treatment, whereas the later decrease in serum AGP parallels the clinical course of the infection. Thus the determination of these proteins can help to guide the treatment of infection in newborn infants.
 ...
PMID:Evolution of serum prealbumin, C-reactive protein, and orosomucoid in neonates with bacterial infection. 620 73

In a prospective study serum C-reactive protein (CRP) was measured in 100 premature infants. All babies were suspected of having bacterial infection (septicemia - meningitis) because of complications during pregnancy and/or during the perinatal period. CRP was measured with the radial immunodiffusion technique. 6/6 babies with bacterial infections proved by positive cultures from blood and/or CSF showed elevated levels of CRP already within 24 h after the first appearance of clinical symptoms suggesting sepsis. In 11 of 21 cases most probably suffering from septicemia CRP rose within a period of 82 h after the appearance of clinical signs. Even extremely immature infants were able to react with elevated CRP concentrations. Peak values of CRP were independent of birth weight. On the other hand, only 2 of 73 babies without clinical or laboratory findings of infection had slightly elevated amounts of CRP for a short time. Therefore it is suggested that increased levels of serum CRP are a valuable parameter for the early diagnosis of severe bacterial infections in premature infants.
 ...
PMID:[Significance of C-reactive proteins (CRP) in serum in bacterial infections of premature infants]. 641 42

In 312 preterm and term newborn infants serum concentrations of C-reactive protein (CRP), haptoglobin and alpha 1-antitrypsin were measured during several days by radial immunodiffusion. In addition white blood cell count and the ratio of band to total neutrophils (B/N-ratio) were determined. In 12 infants with proven sepsis CRP was found elevated above the upper limit of the normal range (20 mg/l). Successful therapy was followed by a decrease of CRP concentration. In infants with suspected infection high CRP values were found in most cases. In contrast, haptoglobin and alpha 1-antitrypsin concentrations differed not significantly between the group of infants without infection, with proven and with suspected infection. White blood cell count and B/N-ratio also were not appropriate for the early identification of bacterial infection in the newborn period.
 ...
PMID:Sequential determination of CRP, alpha 1-antitrypsin and haptoglobin in neonatal septicaemia. 641 19

C-reactive protein were assayed both with immunodiffusion and precipitation on latex C-reactive protein in 216 samples of sera from newborns with suspected septicemia. Both methods correlated well (r = 0.92) rendering the second one rather useful for early diagnosis of neonatal sepsis, since it produces results within a few minutes independent of complicated apparatus or trained personal.
 ...
PMID:[C-reactive protein--determined by radial immunodiffusion and compared to the latex agglutination method]. 643 92

Serum C-reactive protein (CRP) is known to be produced by full-term infants and children in many diseases causing severe inflammation. We examined the usefulness of CRP as an early indicator of bacterial infection in premature newborn infants. CRP was obtained from 100 patients enrolled in a prospective study. All babies were suspected of having bacterial infection (meningitis-septicaemia) because of complications during pregnancy and/or symptoms suggestive of infection during the perinatal period. CRP was measured with the radial immunodiffusion technique. Examinations were done daily as long as elevated serum CRP levels were found. 100% (6/6) of our patients with culture-proven bacterial infections showed elevated CRP values within 24 h after the first clinical or laboratory signs suggesting sepsis. In 52.3% (11/21) of cases most probably suffering from infection, CRP rose within 72 h after the appearance of other symptoms. Even extremely immature infants were able to react with elevated CRP concentrations. Peak values of CRP were independent of birth weight. On the other hand, only 2.7% (2/73) of babies without findings of infection had slightly elevated amounts of CRP for a short time. Thus, serum CRP levels are a helpful parameter for the early diagnosis of severe bacterial infection in premature infants.
 ...
PMID:Serum C-reactive protein in early diagnosis of bacterial infections in premature infants. 647 71

A study of 214 neonates (with 87 premature infants) reveals that C-reactive protein (CRP), orosomucoid and prealbumin are the most interesting proteins for the diagnosis of neonatal sepsis and for studying its follow-up. Orosomucoid is high in 85% of bacterial infections and CRP in 75%. Early type strep B infections give often false negative results. The evolution of CRP and of prealbumin corresponds to the effects of treatment and the evolution of orosomucoid is parallel to the healing of the patients. The ratio orosomucoid/prealbumin allows an earlier appreciation of the healing.
 ...
PMID:[Course of inflammatory and nutrition proteins in bacterial infections in newborn infants]. 652 81

C-reactive protein (CRP) was evaluated as an indicator of septic bacterial infections in children with acute lymphoblastic leukemia (ALL). Thirty-five children with newly diagnosed ALL and 10 children receiving antileukemic chemotherapy developed 13 episodes of verified septicemia. Newly diagnosed ALL alone influenced the CRP level moderately; half of the children with no concomitant bacterial infection had measurable CRP values. However, the CRP values in this group were significantly lower than those in children with proved septicemia in whom the CRP level ranged from 15 to 340 mg/liter (median, 125 mg/liter). We conclude that CRP levels exceeding 100 mg/liter indicate bacterial septicemia with a high specificity regardless of the stage of ALL. Moreover, a negative CRP value virtually excludes septicemia. Patients ith moderately elevated CRP values, i.e. under 100 mg/liter, should be closely observed. Sequential CRP determinations are useful in children with invasive bacterial infections.
 ...
PMID:C-reactive protein in rapid diagnosis and follow-up of bacterial septicemia in children with leukemia. 657 7

Eight episodes of clinical septicemia in five children were assessed using C-reactive protein (CRP) determinations. The measurements were performed turbidimetrically, with quantitative results available in less than 10 minutes. Three patients had epiglottitis, one had recurrent septicemia secondary to severe underlying illnesses and one patient was followed postoperatively after open heart surgery. Regardless of etiology septicemia was consistently associated with a rapid increase (greater than or equal to 20 to 214 mg/liter) in the CRP concentration. Elevated values were obtained 5, 13 and 16 hours after the onset of symptoms of epiglottitis. When determined the CRP level was invariably elevated at the time of the first positive blood culture. CRP determinations in patients with symptoms of septicemia would have supported the diagnosis at least 24 hours before the positive blood culture. In addition, sequential CRP measurements proved beneficial in monitoring the course of septicemia.
 ...
PMID:Rapidity of C-reactive protein in detecting potential septicemia. 660 20


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>