Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From 1979 to 1986, 82 infants underwent surgical treatment for necrotizing enterocolitis (NEC), with 36 deaths. The records of 30 of the 36 infants who died were available for review. Fungal colonization and sepsis, the sites of infection, and timing of diagnosis and therapy were determined. Sixteen of 30 (53%) neonates had no evidence of fungus. Six (20%) were colonized with Candida species. Eight (27%) had fungal sepsis, with two of these eight found only at necropsy. Positive fungal blood cultures were a late finding. In only four of the six patients with positive blood cultures were the results known in time to initiate treatment with amphotericin B. Two of these four babies received less than 2 days of amphotericin B treatment prior to death. Fungal sepsis is a significant lethal factor in the surgical mortality of NEC. Vigorous efforts at earlier diagnosis are mandatory.
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PMID:The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. 212 15

Patients treated with cytotoxic therapy expected to produce neutropenia lasting two or more weeks were randomly assigned in a double-blind study to receive intravenous miconazole or placebo concomitant with empiric antibiotics to test whether miconazole can prevent fungal sepsis. The study drug was initiated at the time of first fever along with antibiotics and was continued until neutropenia resolved, fungal sepsis occurred, or persistent or recurrent unexplained fever after six or more days prompted substitution of the study drug by amphotericin B. Two hundred eight treatment courses in 180 patients were evaluated. Fungal sepsis occurred in only one patient receiving miconazole compared with eight patients receiving placebo (p = 0.03). Fatal fungal sepsis occurred in four patients receiving placebo and in none of the patients receiving miconazole (p = 0.08). There was no evidence for the development of resistance to polyenes or imidazoles in fungal isolates recovered from patients in this randomized trial or an increase in Aspergillus infections in patients who received miconazole in this randomized trial or in 121 subsequently treated patients who received unblinded use of miconazole. Thus, intravenous miconazole was more effective than placebo in preventing fungal sepsis in patients with chemotherapy-induced prolonged neutropenia.
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PMID:Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole. 333 68

Of 53 surgical cases complicated with severe infection who were admitted to The Second Department of Surgery of Osaka University Hospital between 1975 and 1982, 9 cases were suffered from sepsis with positive blood culture for Candida albicans. All cases developed DIC and subsequent multiple organ failures (MOF), which was likely triggered by fungal sepsis because of the absence of any coexisting pathogens. Fungal sepsis was developed following a long term massive antimicrobial therapy in 7 cases and also following a long term steroid therapy in 1 cases. No apparent portal of fungal entry was confirmed except 3 cases with a positive fungal culture for central venous catheter. Six cases were fatal without improvement of DIC or MOF, to whom no early administration of antifungal agents was performed due to lack of recognition of fungal virulence. However, 3 cases were completely recovered from DIC and MOF by treatment with antifungal agents and anticoagulants. These observations suggest that DIC due to fungal sepsis may be eradicated by recognition of fungal virulence and by appropriate treatment with antifungal agents and anticoagulants.
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PMID:[Fungal sepsis and DIC in surgical patients]. 642 97

Fungal sepsis is an important cause of fever resistant to antibiotic therapy that is very often taken into marginal account. It should instead be particularly considered in patients with a long history of immune depression such as diabetes or chronic and debilitating diseases. Blood cultures are essential for diagnostic purposes, preferably performed in antibiotic wash-out, since they may allow identification of pathogenic (or opportunistic) fungi responsible for episodes of fungal sepsis. The case described illustrates an episode of systemic infection by Rhodotorula glutinis correlated with the presence of CVC.
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PMID:[Rhodotorula glutinis sepsis. A case report]. 2061 Sep 37