Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Calciphylaxis is a rare disease primarily affecting patients dependent on dialysis. It is characterised by small vessel media calcification leading to cutaneous ischemia and necrosis. The mortality rate is high with infection and sepsis being the most common causes of death. Calcium salts, vitamin D and high levels of serum calcium and phosphorus increase the risk of calciphylaxis. Current therapies including restoration of mineral homeostasis, wound care and pain control, are not entirely effective. Sodium thiosulfate, by dissolving calcium deposits, is a novel therapeutic choice for calciphylaxis. It has proved successful also in cases refractory to conventional treatment.
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PMID:[Sodium thiosulfate--new hope for the treatment of calciphylaxis]. 2197 87

Campylobacter rectus, formerly known as Wolinella recta, is an anaerobic Gram-negative bacillus, generally recognized as an agent responsible for severe periodontitis; only two cases of extra-oral infections have been reported. The first case of septicemia with C rectus and Actinomyces odontolyticus is described in a 37-year-old farmer who suffered from severe sacroiliitis. Also presented are a review of C rectus in human pathology, and a brief review of pyogenic sacroiliitis, a rather rare disease.
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PMID:Sacroiliitis and septicemia caused by Campylobacter rectus and Actinomyces odontolyticus. 2234 89

Scurvy, lack of vitamin C, is a rare disease and is often called seafarers' disease. This case story describes a 36 year-old female patient with scurvy after a gastric bypass operation. Scurvy led to severed bullae on the skin, haemorrhagia and loose skin. After intensive care treatment and a minor split skin graft the patient was discharged from the university hospital to a local hospital for further mobilization. Three months later the patient died due to sepsis.
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PMID:[Scurvy is not entirely a historical disease]. 2234 73

Lemierre syndrome is an extremely rare disease characterized by oropharyngeal infection, septicemia, internal jugular vein thrombosis, and skip lesions. The most common causative pathogen is Fusobacterium necrophorum. We reported a 45-year-old woman who presented with left neck painful swelling and septicemia. Magnetic resonance imaging of the head and neck demonstrated venous thrombosis extending from the left internal jugular vein to the sigmoid sinus. During admission we discovered that the patient had uncontrolled diabetes mellitus. We also found a metastatic lesion through chest radiography. Klebsiella pneumoniae was cultivated from both blood samples and pus from deep neck spaces. Surgical drainage, early and adequate antibiotic treatment, anticoagulation, and strict control of blood glucose led to the patient's complete recovery. Because Lemierre syndrome is a forgotten disease in the era of antibiotics, awareness of the signs and symptoms of this disease is important because of its associated high mortality rate. This case illustrated that the presence of K pneumoniae can lead to Lemierre syndrome.
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PMID:A Lemierre syndrome variant caused by Klebsiella pneumoniae. 2281 19

Infective endocarditis (IE) is a relatively rare disease that can take part of sepsis and may be a diagnostic and therapeutic challenge. Polyvalvular location of El is rare. We present a patient of 60 years diagnosed with plurivalvular infective endocarditis by Enterococcus faecalis with septic complications, visceral, dragged, hospitalized for a psychiatric pathology, who raised the problems of diagnosis and treatment, without being able to make assessments on the entrance gate. For help in diagnosing this case proved that cardiac ultrasound studies recommended that a screening method for patients with bacteremia, but the presence of vegetation is the major criterion for diagnosis of EI. Blood cultures and echocardiography led to the diagnosis of infectious endocarditis. Also abdominal ultrasound confirmed the clinical suggestion of gravity, the septic multiviscerale release by splenic abscess image objectivity. Under vigorous antibiotic treatment and symptomatic treatment in combination evolution was to worse, death occurring after 15 days of hospitalization, toxic-septic shock being irreversible. Our case is particular by locating polyvalvular vegetation, the germ involved, the court altered the immunological and disseminator septic complications that have limited therapeutic options and made predictable fatal diagnosis.
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PMID:[Multivalvular infective endocarditis with Enterococcus faecalis]. 2307 30

After infection of a vascular prosthesis with generalised sepsis, a 59-year-old male patient suffered from an increasing swelling of his right sternoclavicular joint. We performed an incision and debridement of the SC joint and harvested material for microbiological diagnosis. However, we were not able to overcome the inflammation until we performed a radical resection including the medial aspect of the clavicle and parts of the manubrium followed by coverage with a pectoralis flap. The further course was uneventful with a good functional result. Reviewing data from the literature there are no unequivocal guidelines available for this rare disease. However, in most cases a radical debridement and a consecutive flap coverage are required.
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PMID:[Septic arthritis of the sternoclavicular joint: radical resection and treatment with a pectoralis flap]. 2329 58

Neonatal listeriosis is not a rare disease, but it is infrequently diagnosed and reported in the literature. Herein we report a case of listeria lethal sepsis, followed by increased cytokines levels in the cord blood, in which diagnosis was made possible by histological examination of the placenta.
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PMID:Neonatal listeriosis: the importance of placenta histological examination-a case report. 2370 75

Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently new medical treatments emerged aiming to normalize disturbances of minerals to reduce the serum concentration of sodium phosphate and to prevent precipitation and calcification. Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement.
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PMID:Update on cutaneous calciphylaxis. 2371 95

Organic or non diabetic hypoglycemia (NDH) is a rare disease when it is confirmed, but is often confounded with low blood glucose concentration (between 3 and 4 mmol/I), which is much more frequent. NDH's definition requires the Whipple triad (plasma glucose level <2.8 mmol/l, symptoms of neuroglycopenia and their relief with administration of sugar). The diagnostic approach needs to differentiate the healthy from the sick patient, who's hypoglycemia causes are multiple and frequent, such as: toxic (medicament, OH), organ deficiency, denutrition and sepsis. When hypoglycemia is suspected, without evident causes in healthy persons, it should be investigated by a 72 h fast test, in order to guide the diagnosis. After confirmation of an endogen hyperinsulinism only, sophisticated imaging should be done to localize the tumor and/or to exclude alternatives diagnosis.
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PMID:[Non diabetic hypoglycemia: diagnosis and management]. 2379 88

Congenital malaria is a rare disease both in endemic and non-endemic areas. It is seldom suspected due to its rarity and the fact that its signs and symptoms may be similar to those with neonatal sepsis. Furthermore, clues such as a history of maternal travel to an endemic area during pregnancy or any malaria symptoms may not always be revealed. The situation is further complicated by subjective smear tests and an expensive rapid diagnostic test, especially in developing countries where affordability is an issue. We call attention to the need to consider the diagnosis of malaria in neonates who present with signs and symptoms often confused with sepsis, to enable a quick diagnosis and treatment in order to reduce mortality.
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PMID:Congenital vivax malaria: rare or underdiagnosed infection. 2406 17


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