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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors studied the frequency of sinusitis in nasotracheally intubated patients in an Intensive Care Unit. All patients intubated nasotracheally during an 8 day period were included in a prospective study which included CT scanning with views of all the paranasal sinuses. Sinusitis was defined as opacification of the sinus with an air-fluid level. Transantral punctures were performed in cases of maxillary sinusitis. Fifty-three patients were included. Local symptoms and/or unexplained fever were present in 22% of cases. CT scanning showed sinusitis in 49 of the 53 cases (pansinusitis 42 cases, maxillary alone 5 cases, sphenoidal 16 cases). Bacteriological cultures of sinus punctures were positive in 39 cases, monomicrobial in 21 and polymicrobial in 18 cases. Twenty of the 53 patients developed a lower respiratory tract infection with the same germ and 10 developed septicemia (3 with isolated sinusitis and 7 with pneumonia). Eighteen patients died (6 of their infection and 12 of the underlying disease). This study shows the high frequency of bacterial sinusitis and the necessity of sinus puncture for bacteriological identification of the causal organism to adapt antibiotic therapy.
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PMID:[Nosocomial sinusitis and nasotracheal intubation. Prospective study of 53 patients]. 274 57

In the past decade, mucormycosis has emerged as an important lethal infection in diabetics and other immunocompromised hosts. Rhinosinusitis, pansinusitis, rhino-orbital and rhinocerebral are the common classical manifestations of mucormycosis. However, primary gastrointestinal (GI) mucormycosis is an uncommon disease associated with a high mortality rate. Stomach is the most common site involved in GI mucormycosis. Reported cases of GI mucormycosis in an immunocompetent host are very few in the literature. Here we present a case of a young male with fungal sepsis secondary to GI mucormycosis in an immunocompetent person.
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PMID:Primary gastrointestinal mucormycosis in an immunocompetent person. 1924 86

The authors describe 2 cases of young men who presented with pansinusitis and Fusobacterium necrophorum orbital abscesses. The first patient had a complicated clinical course including epidural abscess formation and meningitis. He underwent surgical evacuation of the abscesses and sinus drainage and required long-term broad spectrum antibiotic therapy with full recovery. The second patient had a clinical course complicated by F. necrophorum septicemia. He required surgical evacuation of the abscess, sinus drainage, and long-term broad-spectrum antibiotic therapy and has remained asymptomatic since. F. necrophorum may be emerging as an increasingly prevalent pathogen in orbital abscesses and can portend a more aggressive clinical course where early surgical intervention may be prudent.
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PMID:Orbital abscesses caused by Fusobacterium necrophorum. 2068 77

Rhino-orbital mucormycosis is a fatal infection. Decompensated diabetes is the most common predisposing factor. Two male adults were admitted because of newly diagnosed diabetes with hyperglycemic hyperosmolar state and CT scan showed extensive pansinusitis and orbital inflammation. Treatment included surgical debridement and antifungal therapy. One patient died from a severe sepsis.
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PMID:Hyperglycemic hyperosmolar state and rhino-orbital mucormycosis. 2110 69

This paper was designed to illustrate the probability of the development of an oncological disease of the nasal cavity and the paranasal sinuses in young subjects presenting with long-standing decompensated chronic sinusitis; also, it demonstrates the possibility of long-term remission after surgical elimination of the inflammatory process. A 28 year-old patient is described having decompensated chronic pansinusitis complicated by sepsis and secondary suppurative dacryocystitis. Multiple surgical interventions on several paranasal sinuses for the treatment of this pathology proved inefficient and were followed by sanation rhinosinusotomy with the simultaneous removal of the malignant tumour. The long-term monitoring of paranasal sinus condition after radical pansinusotomy and ablation of the tumour followed by a course of radiotherapy gave evidence of the malignant process with simultaneous elimination of inflammatory changes in paranasal sinuses.
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PMID:[Decompensated sinusitis complicated by cancer of the nasal cavity and the maxillary sinus]. 2137 48

Mokgacha K, Maruza MP, Sesay SO, Rwegerera GM. Cavernous sinus thrombosis in a 14-year old boy. Turk J Pediatr 2017; 59: 719-723. Cavernous sinus thrombosis (CST) is a rare, life-threatening disorder occurring as a result of sepsis or secondary to aseptic causes in the setting of a thrombophilic disorder that has over the years been linked to high morbidity and mortality rates; this being despite availability of a wide number of new broad-spectrum antibiotics. We present a case of a 14-year old boy who had presented with two weeks` duration of worsening bitemporal headache followed by facial swelling on the background history of chronic non-specific headache of few months duration. He was diagnosed to have cavernous sinus thrombosis secondary to pansinusitis. The course of his illness was complicated by a stroke despite prompt treatment with antibiotics and anticoagulation. The case highlights the importance of high index of suspicion in patients with unexplained headache and need for investigation and early referral to prevent occurrence of cavernous sinus thrombosis.
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PMID:Cavernous sinus thrombosis in a 14-year old boy. 3003 10