Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hospital records of 198 patients with wound dehiscence following gastrointestinal surgery were reviewed (median age 66 years, male:female ratio 2.5:1). The median time from primary surgery to wound dehiscence was six days (1-24 days). The postoperative course prior to dehiscence was uneventful in half of the patients, and two-thirds had evidence of bowel function. The overall mortality rate following dehiscence was 24%. The most common cause of death was cardiorespiratory insufficiency (58%) and peritoneal sepsis (15%). Factors without influence on mortality were: 1) Complicating illness prior to surgery. 2) Primary disease. 3) Emergency surgery. 4) Contamination of the wound. 5) Postoperative complications prior to rupture. 6) Absence of bowel function. 7) Complete or incomplete rupture of the wound. Mortality, however, was higher in females, in patients with longitudinally versus transverse incisions, and in elderly patients. Late incisional hernia or sinus reactions occurred in 34 patients (23%).
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PMID:Burst abdomen--clinical features and factors influencing mortality. 161 25

The short-term outcome with survival rate, causes of death and neonatal complications in a 6-year material comprising 253 infants treated with intermittent positive pressure ventilation (IPPV) in the neonatal period has been analyzed in relation to different primary disorders necessitating IPPV treatment. The total survival rate was 53%. For the different diagnoses the survival rates were: hyaline membrane disease (HMD) 41%, apnoea repetens of immaturity 85%, severe birth asphyxia 46% and septicemia 59%. The total rate of pneumothorax during IPPV was 15% but occurred more often in the HMD group (28%). Trends in survival rates over the study period are discussed as are measurements for improvements.
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PMID:Evaluation of mechanical ventilation in newborn infants. I. Techniques and survival rates. 698 51

The delivery of a distressed term infant is infrequent but often requires intensive therapy. This study investigates the primary causes for such distress and the period (antepartum intrapartum, neonatal) when each complication was initially recognized. During a 1-year period, 168 term infants (8% of 2,057 term deliveries) required admission to the newborn intensive care unit. The primary disorders were similar to those of 228 infants transported from community hospitals and involved suspected sepsis, metabolic problems, major anomalies, birth asphyxia, and respiratory distress. Only one third (59 cases, 35%) of the subsequently distressed infants was anticipated during the antepartum period. The term infant who requires more than routine nursery care cannot necessarily be predicted until labor or delivery.
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PMID:Predictability of the distressed term infant. 724 81

Mitochondrial encephalomyopathies are under increasing consideration in the differential diagnosis of diverse metabolic diseases from infancy to late adulthood. This is to be expected considering the vital importance of mitochondria to cellular respiration in all eukaryotes. the vulnerability of the mitochondrial genome to injury, and the expanding appreciation of the role of mitochondria as a common denominator in cell death in ischemia/anoxia, sepsis, and neurodegenerative diseases. Primary disease of the mitochondrial respiratory chain is estimated to occur with an incidence of between 6 and 16/100,000 individuals. Virtually all tissues have been shown to be involved in diverse mitochondriopathies, but none is more appropriate for diagnosis in most cases than skeletal muscle. The conventional histological and ultrastructural diagnosis of mitochondrial disease in muscle has been increasingly supplanted by the biochemical assessment of respiratory chain enzyme deficiencies and definitive genetic diagnosis. The use of such techniques has afforded a greater understanding for the relative lack of specificity of both light and electron microscopic observations. A review of the current situation by placing muscle pathology in the context of biochemical and genetic diagnosis serves as a paradigm for the role of the pathologist in the molecular era.
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PMID:Mitochondrial myopathies and the role of the pathologist in the molecular era. 1124 7

The renal transplant program at the MUSC was established in 1968 and is the only transplant center in South Carolina. It serves a large population of African American patients who constitute nearly two-thirds of the waiting list and more than half of all renal transplants. Between 1968-2000, 969 transplants were performed in 906 AA patients. Most received organs from cadaveric donors, while only 99 (10%) of AA patients received living donor transplants. The acceptance of living unrelated donors and the use of laparoscopic nephrectomy have had a negligible impact on living donations in this racial group. Primary disease had little effect on outcome except in diabetics whose mortality was higher. The one-year graft survival rates improved dramatically with the aggressive use of CsA without the use of antibody induction. The overall one- and 5-year graft survival rates improved from 53% and 32%, respectively, in the 1978-1983 era to 87% and 59%, respectively, in the 1993-2001 era. At MUSC, the emphasis has been on reducing mortality due to sepsis by limiting the number of rejections treated particularly in recipients of cadaveric organs. While this has resulted in reduced overall early mortality, it has not adversely affected graft survival. Our experience suggests that while short-term graft survival has improved significantly over the years for AA patients, the long-term outcome still remains relatively unchanged.
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PMID:Cadaveric renal transplantation in African-Americans in South Carolina. 1221 76