Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors describe the case of a 53-year-old woman who suffered from an Aspergillus fumigatus infection of the L2/3 intervertebral disc space unrelated to previous operations on her lumbar spine. After surgical debridement combined with amphotericin therapy she died on the 23rd postoperative day from a fulminant bacterial sepsis of pulmonary origin. Although she had intermittently used steroids for bronchial asthma, this is an unusual case of fungal infection of the lumbar spine in an apparently immunocompetent patient.
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PMID:Intervertebral disc space infection caused by Aspergillus fumigatus. 883 Nov 27

We investigated the prophylactical administration of liposomal amphotericin B (Ambisome) in the early phase after liver transplantation (LTx). Fifty-eight patients received Ambisome prophylactically after LTx. Ambisome (1 mg kg-1 day-1) was given intravenously for 7 days after LTx. Immunosuppressive prophylaxis was cyclosporin A (CsA) based in 11 patients. Forty-seven patients had a tacrolimus-based immunosuppressive regimen. CsA and tacrolimus dosages were adjusted to trough levels of 150-250 ng ml-1 (EMIT) and 5-15 ng ml-1 (MEIA II) respectively. Three patients died from sepsis due to Aspergillus fumigatus infection. Reasons for a fatal outcome were foudroyant Aspergillus pneumonia in a patient transplanted for fulminant hepatic failure on post-operative day (pod) 8; Aspergillus sepsis with severe endocardidtis in a patient with two retransplantations for graft non/dysfunction on pod 24; and disseminated aspergillosis due to Aspergillus fumigatus in a patient retransplanted for primary non-function (pod 19). All three patients underwent haemofiltration for renal failure. One patient with Candida albicans sepsis (pod 4) recovered under increased dosage of Ambisome (3 mg kg-1 per day). Ambisome (1 mg kg-1 per day) seems to be beneficial against systemic Candida infections. However, the onset of systemic Aspergillus infections could not be prevented. Obviously, higher Ambisome doses appear to be necessary against Aspergillus. We recommend the use of Ambisome (3 mg kg-1 per day) for patients with risk factors such as graft dys-/non-function, retransplantation, haemofiltration and complicated acute liver failure to prevent invasive aspergillosis.
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PMID:Systemic mycoses during prophylactical use of liposomal amphotericin B (Ambisome) after liver transplantation. 1039 48

Hepatic abscess caused by Aspergillus fumigatus infection is rare. The incidence of fungal hepatic abscess has recently increased. We report a case of Aspergillus fumigatus infection in a 66-year-old man with aplastic anemia who presented with intermittent high fever. He had received splenectomy about 2 years before this admission followed by treatment with anti-human thymocyte globulin, corticosteroids, and cyclosporin. Abdominal sonography and computerized tomography scan of the liver revealed a hepatic abscess and empiric broad-spectrum antibiotics were administered, but fever persisted. Culture of abscess aspirate yielded Aspergillus fumigatus. Amphotericin B was administered, but the patient died of sepsis. With the increasing number of immunocompromised patients, various fungal infections, including Aspergillus fumigatus, are increasingly common, and this infection can be very serious with fatal outcome. Alertness to the possibility that fungal infection may be present when an immunocompromised patient with hepatic abscess presents in hospital is important to decreasing morbidity and mortality.
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PMID:Hepatic abscess caused by Aspergillus fumigatus infection following splenectomy and immunosuppressive therapy. 1451 90