Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036690 (
sepsis
)
59,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Antithrombin deficiency
(
ATD
) was described in 1965 by Olav Egeberg as the first known inherited form of thrombophilia. Today, it is understood that ATDs can be congenital or acquired, leading to qualitative, quantitative, or mixed abnormalities in antithrombin (AT). All ATDs ultimately hinder AT's ability to serve as an endogenous anticoagulant and antiinflammatory agent. As a result,
ATD
patients possess higher risk for thromboembolism and can develop recurrent venous and arterial thromboses. Because heparin relies on AT to augment its physiologic function, patients with
ATD
often exhibit profound heparin resistance. Although rare as a genetic disorder, acquired forms of
ATD
are seen with surprising frequency in critically ill patients. This review discusses
ATD
in the context of surgical critical care with specific relevance to trauma, thermal burns, cardiothoracic surgery, and
sepsis
.
...
PMID:Antithrombin Deficiency in Trauma and Surgical Critical Care. 3279 2
