Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mokgacha K, Maruza MP, Sesay SO, Rwegerera GM. Cavernous sinus thrombosis in a 14-year old boy. Turk J Pediatr 2017; 59: 719-723. Cavernous sinus thrombosis (CST) is a rare, life-threatening disorder occurring as a result of sepsis or secondary to aseptic causes in the setting of a thrombophilic disorder that has over the years been linked to high morbidity and mortality rates; this being despite availability of a wide number of new broad-spectrum antibiotics. We present a case of a 14-year old boy who had presented with two weeks` duration of worsening bitemporal headache followed by facial swelling on the background history of chronic non-specific headache of few months duration. He was diagnosed to have cavernous sinus thrombosis secondary to pansinusitis. The course of his illness was complicated by a stroke despite prompt treatment with antibiotics and anticoagulation. The case highlights the importance of high index of suspicion in patients with unexplained headache and need for investigation and early referral to prevent occurrence of cavernous sinus thrombosis.
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PMID:Cavernous sinus thrombosis in a 14-year old boy. 3003 10

A woman in her 60s with multiple sclerosis (MS) presented with right-sided ptosis, right sixth nerve palsy, right facial paraesthesia and signs of sepsis. She had a recent diagnosis of a dental abscess. Investigations revealed a right submasseter abscess leading to bacterial meningitis (Streptococcus intermedius) and a cavernous sinus thrombosis. She was managed in intensive care and underwent surgical drainage of the abscess. Anticoagulation for 6 months was planned. Cavernous sinus thrombosis is a very rare complication of a dental abscess, and even less frequently associated with submasseter abscesses. The case was complicated by a history of MS, to which the patient's symptoms and signs were initially attributed to. This case highlights the diagnostic pitfalls, and aims to enhance learning around similar cases. To the best of our knowledge, this is the first case report of a masseter/submasseter abscess leading to cavernous sinus thrombosis.
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PMID:Diagnostic difficulties in a patient with multiple sclerosis who presents with cranial nerve palsies: an unusual complication of dental work. 3312 21