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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In anesthesized pigs, hemodynamic measurements and gated bloodpool scintigraphy were performed during and after infusion of live Escherichia coli (2 X 10(8)/kg). Ejection fractions (EF) as well as the relation between end-diastolic volumes (EDV) and stroke work (SW) were used to evaluate changes in left (LV) and right ventricular (RV) function. Porcine E. coli sepsis proved to be characterized by pulmonary vascular hypertension (PVH) and systemic arterial hypotension, accompanied by a reflex increase in heart rate. Systemic flow remained essentially unchanged. E. coli infusion resulted in pronounced and opposite changes in LV and RV preload. RVEDV increased initially and then returned to the value observed before E. coli infusion. LVEDV showed a continuous decrease during the observation of 3 hours. Alterations in LVSW and RVSW appeared to parallel the changes in LVEDV and RVEDV. No significant changes in LVEF and RVEF were found. It is concluded that porcine E. coli sepsis might be a suitable model for human sepsis complicated by PVH. In this animal model no clear signs of myocardial depression or evidence of right heart failure were observed.
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PMID:Left and right ventricular function in porcine Escherichia coli sepsis. 388 76

Ventriculoatrial shunts were first developed in the 1940s and shortly thereafter became the treatment of choice for noncommunicating hydrocephalus. Although the mortality rate for noncommunicating hydrocephalus has fallen from 80% to 20%, ventriculoatrial shunts continue to have major life-threatening complications such as thromboemboli, infection, and shunt malfunction. This report presents the cases of two adult hydrocephalic patients who developed pulmonary emboli and sepsis after being treated with ventriculoatrial shunts. One patient, whose complications were not recognized until late in the course, died of pulmonary hypertension and right heart failure despite removal of the shunt and aggressive medical therapy. Complications in the second patient were discovered early, the shunt was removed, and intravenous antibiotics were used for weeks to combat sepsis and bacterial endocarditis.
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PMID:Thromboembolic complications of ventriculoatrial shunts. 649 51

The majority of evidence suggests that there is myocardial dysfunction resulting from sepsis. Clinical observations seem to suggest that the dysfunction is not on the basis of decreased venous return of increased afterload. Reduced myocardial compliance and isolated right ventricular failure also do not account for what is seen clinically. The explanation appears to be decreased myocardial contractility. Several factors may be responsible for reducing contractility, including altered response to catecholamines; metabolic acidosis; altered distribution of blood flow within the myocardial wall resulting in hypoxic regions; the elaboration of substances that act directly to reduce contractility, including intestinal shock factors and endorphins; and alterations of excitation-contraction coupling resulting from changes in calcium concentrations or reduced responsiveness to the calcium ion. Further work is needed to determine which of these factors predominate.
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PMID:Myocardial failure. 706 58

Paediatric cardiac transplantation (pHTX) has gained widespread acceptance as a therapy in end-stage myocardial failure and some forms of congenital heart disease, particularly hypoplastic left heart syndrome (HLHS). The major problems to the anaesthesiologist in these patients are induction of anaesthesia in infants with HLHS and treatment of pulmonary hypertension in the early post-bypass period. PATIENTS AND METHODS. Anaesthesia for pHTX was performed in 15 children < 1 year of age (4-237 days); 12 suffered from HLHS, 2 from endocardial fibroelastosis, and 1 from dilatative cardiomyopathy. Induction of anaesthesia in patients with HLHS IS a challenge to the anaesthesiologist, as he has to maintain the delicate balance between pulmonary and systemic blood flow. Anaesthesia was induced with fentanyl (10-15 micrograms/kg) and pancuronium (0.2-0.4 mg/kg) and maintained with fentanyl (total dosage 70-100 micrograms/kg). Modification of ventilatory parameters such as FiO2, PaCO2, and airway pressure (PEEP, I:E ratio) was used to influence systemic and pulmonary blood distribution in the pre-bypass period according to changes in haemodynamics (target: O2 saturation approximately 75%-80%, PaCO2 45-50 mmHg). Treatment of pulmonary hypertension in the weaning and early post-bypass period consisted of respiratory (PaCO2 < 30 mmHg) and metabolic alkalinisation (pH 7.45-7.55, BE > +3 mmol/l), the use of prostaglandin E1 (3-6-12 micrograms/kg.h), and the phosphodiesterase inhibitor enoximone (10-15 micrograms/kg.min). Additional positive inotropic support was achieved with dobutamine (5-10 micrograms/kg.min), adrenaline (0.1-0.5 micrograms/kg.min), and/or orciprenaline (0.1-0.2 micrograms/kg.min) and calcium chloride (25-100 mg/kg). RESULTS. Two children died intraoperatively and 1 on the 1st postoperative day from overwhelming pulmonary vascular resistance and right ventricular failure. Three children died between 3 and 4 weeks postoperatively, 1 from cytomegalovirus infection, 1 from sepsis, and 1 from acute rejection. Nine patients survived and are well up to 5.5 years after transplantation. CONCLUSION. Pulmonary hypertension in the weaning and early post-bypass period is the main anaesthesiological problem of pHTX, particularly in children with HLHS. A polypragmatic approach to this problem consisting of alkalinisation, pulmonary vasodilatation, and inotropic support is presented and seems to be effective. Further improvements in concepts of pHTX are limited by the lack of donor organs. Though the experience with pHTX in neonates and infants is growing slowly, it might be a routine procedure from the anaesthesiological point of view within a few years in some selected centres.
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PMID:[Anesthesia for heart transplantation in newborn and suckling infants. Special aspects of the hypoplastic left heart syndrome]. 778 53

Development of acute lung injury (ALI) in the critically ill is associated with an array of abnormal interactions between the heart and lungs. Of these abnormalities, increased pulmonary vascular resistance (PVR) is common and seems to indicate a worse prognosis than when PVR is normal. Increased pulmonary artery pressure, which follows ALI in humans, has been attributed to many factors. Early in ALI, pulmonary artery hypertension (PAH) is secondary to an imbalance between the release of vasoactive mediators derived from arachidonic acid, endothelium-derived relaxing factor, and other metabolites. As ALI progresses, the combination of mechanical obstruction and severe regional hypoxic pulmonary artery vasoconstriction probably becomes the main factor responsible for PAH. In addition to these elements, in situ and peripherally derived thromboemboli can be seen in ALI, owing to diverse disturbances in the coagulation and fibrinolytic processes. The result is increased workload of the right ventricle which is caused by increased afterload and may induce hemodynamic disturbances that culminate in overt right ventricular failure. However, epidemiologic studies have demonstrated that death following ALI is more often the result of respiratory failure or sepsis. The absence of effective therapy for PAH in ALI might be explained by the pathophysiological and clinical course of the disease. A reasonable conclusion from the contributing elements cited above is that PAH complicating sepsis and trauma is simply a marker of the gravity of the systemic insult that leads to the development of ALI and probably not a separate process.
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PMID:Cardiopulmonary interactions in acute lung injury: clinical and prognostic importance of pulmonary hypertension. 780 95

From September 1987 to February 1994, we treated 147 patients ranging between 11 and 82 years old with different mechanical circulatory support systems. The applied devices were the Bio-Medicus centrifugal pump in 61 patients, the Abiomed BVS System 5000 in 49 patients, the Thoratec ventricular assist device in 42 patients, and the Novacor left ventricular assist device in 7 patients. On the basis of indication for mechanical circulatory support, the patients were divided into three groups: group 1 consisted of 72 patients with postcardiotomy cardiogenic shock; group 2, 50 patients in whom mechanical support was used as a bridge to cardiac transplantation; and group 3 (miscellaneous), 25 patients in cardiogenic shock resulting from acute myocardial infarction (n = 14), acute fulminant myocarditis (n = 3), primary graft failure (n = 2), right heart failure after heart transplantation (n = 3), and acute rejection (n = 3). Time of support ranged from 1 hour to 97 days (mean duration, 10.8 days). Seventy-five patients (51%) were discharged from the hospital. The best survival rate was achieved in group 2 with 72%, followed by group 1 with 44% and then group 3 with 28%. The most frequent complications in group 1 were bleeding (44%), multiple-organ failure (24%), neurologic disorders (18%), and acute renal failure (15%). In group 2, the major complications were bleeding (34%) and cerebrovascular disorders (22%) and in group 3, multiple-organ failure and sepsis (60%) and bleeding (32%).
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PMID:Mechanical circulatory support: the Bad Oeynhausen experience. 784 Jul 1

Over the last three years, 53 patients underwent transjugular portosystemic shunting (TIPS). 49 patients were treated successfully (92.5%). Procedure-related morbidity (intention to treat) was seen in 11 patients (20.8%): encephalopathy (n = 5), sepsis (n = 3), right heart failure (n = 2) and progressive liver failure (n = 1). 30-day mortality rate was 13.2% (7/53); five of these patients were in stage Child-Pugh C, one patient in stage B, and one patient had a known coronary heart disease. 30-day rebleeding rate was 6.1% (3/49), but all these patients could be retreated successfully by radiological methods (PTA, embolisation, thrombolysis). Angiographic follow-up (mean six months) of 35 patients detected 30 (85.7%) haemodynamic relevant obstructions (stenosis of stent: n = 4, stenosis of hepatic vein: n = 15, stenosis of stent and hepatic vein: n = 5, occlusion of TIPS-shunt: n = 6). Secondary patency rate following percutaneous reintervention was 91.3%. All rebleedings in the follow-up (n = 7) were treated successfully by TIPS-revision. Five out of 12 patients (41.7%) with refractory ascites were treated successfully by TIPS (complete resolution of ascites after three months: n = 4, significant reduction of ascites: n = 1). We conclude that transjugular portosystemic shunt is an effective way of treating portal hypertension, but there is a need to develop methods to prevent the high incidence of shunt stenosis.
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PMID:[Transjugular intrahepatic portasystemic shunt. A new therapeutic method in portal hypertension]. 865 Jun 59

The authors report two cases of pulmonary valve endocarditis which required emergency surgical treatment. A 74 year old patient with trivalvular endocarditis (pulmonary, aortic, mitral), due to Sptreptococcus D bovis, developed cardiogenic shock with acute pulmonary oedema and underwent double aortic and pulmonary valve replacement with Carpentier-Edwards prostheses and simple resection of a mitral valve vegetation. Another 36 year old drug addict developed isolated pulmonary valve endocarditis due to Staphylococcus aureus infection complicated by pulmonary regurgitation with right ventricular failure and by septic pulmonary embolism with persistent sepsis: he underwent pulmonary valve replacement with a Bravo 300 bioprosthesis. The postoperative course was uncomplicated in both cases, with interruption of the infection and normalisation of the haemodynamic status. The insidious and severe nature of pulmonary valve endocarditis is demonstrated by these two cases, confirming previous reports which have underlined the poor prognosis of this condition. Surgery has been shown to be effective and well tolerated and should be integrated early in the therapeutic strategy, the results being all the better when an aggressive attitude is taken.
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PMID:[Pulmonary valve replacement for endocarditis. Apropos of 2 cases]. 876 8

The first clinical application of intraaortic balloon pumps (IABP) in Taiwan was in 1976 to treat post-cardiotomy cardiogenic shock. It is now the most commonly used circulatory assist. From 1991 to 1995, 186 patients received IABP support with an overall mortality rate 41.9%. The male patients had the best survival rate, 67%, after coronary artery bypass grafting. The first extracorporeal membrane oxygenation (ECMO) was in 1987 to treat intractable heart failure caused by severe acute rejection after heart transplantation. Because of poor outcome, patients only received ECMO sporadically during the past years. From November 1994 to November 1995, 30 patients received ECMO support with 50% of them eventually weaned from ECMO and 27% discharged. For short-term support or emergency rescue, ECMO was a good choice. When long-term support was required, the ventricular assist device (VAD) was a more suitable assist. One patient who received Thermedics VAD developed right heart failure and finally died of sepsis and multiple organ failure. VAD should be implanted before the secondary organ failure. The first successful clinical heart transplantation in Taiwan was performed on July 17, 1987. From 1991 to 1995, 102 patients underwent heart transplantation. The operative mortality was 3.9%, and the 1 and 5 year actuarial survival rates were 86 +/- 3% and 77 +/- 5%, respectively. To improve the success rate of clinical heart transplantation, organ donation should be encouraged.
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PMID:Current status of heart assist and replacement in Taiwan. 894 57

In 1996 the total number of prescriptions of the appetite depressant drugs fenfluramine and phentermine exceeded 18 million in the United States. Clinical observation and experimental evidence back in the early 1980's showed that these drugs can cause a pulmonary hypertension. We report the case of a 30-year old woman with a history of seven month medication with dexfenfluramine. She developed severe pulmonary hypertension and right heart failure during late pregnancy. She died of septicemia with multiorgan failure 4 days after cesarean section. Pulmonary hypertension has been reported in association with treatment with fenfluramine and dexfenfluramine. These drugs may cause the increased precapillary resistant pressure through the vasoconstrictor action of serotonin. The typical histological finding is a plexogene pulmonary arteriopathy and valvular heart disease. After these observations the drugs were withdrawn.
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PMID:[Appetite depressants and pulmonary hypertension]. 978 68


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