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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neonatal seizures in the neonatal period are symptoms of numerous underlying disorders of the neonate. We present a case in which neonatal seizures due to cerebral infarction led to a diagnosis in the mother. Neonatal convulsions caused by cerebral artery thrombosis is relatively rare in the neonatal period and is often secondary to indwelling intravascular catheters that cause thromboembolism, but may be associated with many conditions.1 Cerebral artery thrombosis in newborns, in which antiphospholipid antibodies (APA) were found in the mother, has been described in three case reports. Two of these premature infants were born with other risk factors for thrombosis. APA could not be identified in any of these three infants. In the two cases reported by Silver et al the diagnosis was made several months after birth. This case is unique in the fact that no other risk factors for thrombosis could be identified to explain the infarction, and that APA were found in the offspring of an apparently healthy mother. Whether the prior fetal death was caused by APA remains unclear. The finding of lupus anticoagulant in her child led to the diagnosis of antiphospholipid antibody syndrome in her. We believe that in case of cerebral artery thrombosis in a neonate, with no trivial cause such as an indwelling catheter or sepsis, both mother and infant should be tested for presence of APA, even when the mother seems healthy.
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PMID:An unusual cause of neonatal seizures in a newborn infant. 931 May 41

The aim of this study was to assess the contribution of current obstetrical practice to the occurrence and complications of umbilical cord prolapse. Maternal and neonatal charts of 87 pregnancies complicated by true umbilical cord prolapse during a 5-year period were reviewed. Twin gestation and noncephalic presentations were common features (14 and 41%, respectively). Eighty-nine percent (77) of infants were delivered by cesarean section of which 29% were classical and 88% were primary. The mean gestational age at delivery was 34.0 +/- 6.0 weeks, and the mean birth weight was 2318 +/- 1159 g. Obstetrical intervention preceded 41 (47%) cases (the obstetrical intervention group): amniotomy (9), scalp electrode application (4), intrauterine pressure catheter insertion (6), attempted external cephalic version (7), expectant management of preterm premature rupture of membranes (14), manual rotation of the fetal head (1), and amnioreduction (1). There were 11 perinatal deaths. Thirty-three percent of the infants (32) had a 5-min Apgar score < 7 and 34% had a cord pH < 7.20. Neonatal seizures, intracerebral hemorrhage, necrotizing enterocolitis, hyaline membrane disease, persistent fetal circulation, sepsis, assisted ventilation, and perinatal mortality were comparable in the "obstetrical intervention" and "no-intervention" groups. Most of the neonatal complications occurred in infants < 32 weeks' gestation. We conclude that obstetrical intervention contributes to 47% of umbilical cord prolapse cases; however, it does not increase the associated perinatal morbidity and mortality.
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PMID:Current obstetrical practice and umbilical cord prolapse. 1077 64

Newborns in Behira governorate represented 2.5% of total Behira population in 2000. In Damanhour teaching hospital 4040 live births were delivered during one year from 1st January 1995 to 31st December 1995. During this period an observational study of morbidity and mortality of the newborn unit (NBU) attendants was performed. The total number of admitted neonates to the newborn unit were 557, of those 307 were borne in hospital (representing 7.6% of total hospital deliveries) and 250 were admitted from outside the hospital. The number of eligible neonates for the study were 544, they spent 2355 days in the unit, thirteen neonates were excluded from the analysis. The low birth weight (< 2500 gm) were 218 (40% of studied cases). According to Dubowitz score, Infants were classified as appropriate for gestational age (AGA) 60.7%, small for gestational age (SGA) 27.6% and large for gestational age (LGA) 11.8%. Neonates with birth weight < 1500 gm and gestational age < 28 weeks had the worst prognosis with a mortality rate of 60.3% and 65.1% respectively. All neonates had 738 morbid conditions, the major causes were prematurity 262 (35.5%), respiratory distress (RD) 200 (27%) hyperbilirubinaemia 115 (15.6%) and sepsis 58 (7.9%). Most of the cases (73.9%) were admitted on the day of birth. The mortality rate was 28.5%. The leading causes of mortality were, RD ( 34.8% of all deaths), prematurity (32.9%) and sepsis (15.5%). Neonatal convulsions and congenital anomalies had highest case fatality rates (50% for each). Most of deaths (51%) occurred on the first day of admission. "The early results of this work was presented at the 6th international conference of the General Organization of "Teaching Hospitals and Institutes (GOTHI) "Health Services..... Present and future" 7-9 November 2001".
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PMID:A study of neonatal morbidity and mortality at Damanhour Teaching Hospital Newborn Unit. 1726 8