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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence and outcome of streptococcal septicemia was analyzed in 76 consecutive patients with newly diagnosed and relapsed acute myeloid leukemia. They received 215 courses of remission induction or intensive consolidation treatment. There were 31 different episodes of streptococcal septicemia in 27 patients, making these microorganisms the most frequently encountered bacteria in blood cultures. This high incidence coincided with the introduction of selective intestinal decontamination. In 24 episodes (20 patients) there was a fast recovery, but 7 patients developed pulmonary symptoms resulting in death due to respiratory failure in 5 of them. The infections all occurred in the phase of maximum bone marrow suppression 1-3 weeks after the start of the chemotherapy. Streptococcal septicemia was not limited to patients treated with cytosine arabinoside but also occurred in patients treated with other regimens of intensive chemotherapy. In 28 episodes there were no focal signs of infection, but in half there were symptoms of treatment induced gastrointestinal toxicity. The streptococci probably invade through oral and gastrointestinal mucosa damaged by the chemotherapy. Selective decontamination may play a promoting role.
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PMID:Incidence and clinical epidemiology of streptococcal septicemia during treatment of acute myeloid leukemia. 185 64

We have developed an animal model of group B beta Streptococcal sepsis especially conducive to observation of hemodynamic sequelae of the early phases of septic shock. In piglets (N = 7), direct continuous measurements were made of aortic pressure (AOP), left atrial pressure (LAP), central venous pressure (CVP), mesenteric artery blood flow (QMES), and pulmonary artery blood flow, equivalent to cardiac output (CO). Systemic vascular resistance (SVR) and regional mesenteric vascular resistance (MVR) were calculated. Sepsis was induced by bolus intravenous administration of live, washed, type 1b group B beta Streptococcus (GBS) at approximately 1 X 10(10) organisms/kg. Early in septic shock, AOP, LAP, CO, and QMES fell to 66%, 20%, 62%, and 34% of pre-GBS levels, respectively, while SVR and MVR rose to 139% and 224% of control. The decrease in QMES and increase in MVR were significantly more extensive than the fall in CO or the rise in SVR, respectively. Subsequently, systemic hemodynamic function improved over time while regional mesenteric circulation did not. AOP and CO recovered to 86% and 88% of pre-GBS levels, respectively, and SVR returned to 105% of baseline. However, QMES remained only 48% of control, and MVR continued at 173% of pre-GBS levels. Mesenteric blood flow could not accurately be inferred from measurements of either AOP or CO during sepsis in these piglets. Relative mesenteric hypoperfusion persisted despite systemic hemodynamic recovery during this GBS sepsis protocol.
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PMID:Unsuspected mesenteric hypoperfusion despite apparent hemodynamic recovery in the early phase of septic shock in piglets. 388 75

Streptococcus spp are opportunistic pathogens that normally reside in the upper respiratory, intestinal, lower urinary, and genital tracts but can cause localized infection or septicemia in dogs of all ages. A retrospective study of streptococcal infection in 393 dogs was conducted to identify the species of Streptococcus isolated, determine demographics of affected dogs, and characterize the disease processes associated with infection. The major streptococcal species isolated were S canis (88 cases, 22.4%), S dysgalactiae ssp equisimilis (13, 3.3%), and S equi ssp zooepidemicus (4, 1.0%). Sex was not a risk factor (P > .30). Fetuses and neonates were more likely to have streptococcal infection than were other age groups (P < .001). Streptococcal septicemia was considered an important cause of abortion and neonatal death and was isolated from all samples submitted for aerobic culture from dogs in that age group. There was a seasonal trend, with dogs more likely to have streptococcal infection in summer months. In dogs for which a disease process was identified, streptococcal infection was associated with dermatitis (29 dogs), pneumonia (24 dogs), adult septicemia (13 dogs), and fetal/neonatal septicemia leading to abortion or neonatal death (16 dogs). Identification of other clinically significant bacterial, viral, fungal, and parasitic organisms was common (267 of 393 dogs, 68%), especially in dogs with dermatitis or pneumonia. Infection with Streptococcus spp should be considered in the differential diagnosis in cases of abortion, septicemia, dermatitis, and pneumonia in dogs. Clinical significance of isolation of streptococcal organisms should be interpreted in context of clinical signs and pathologic findings.
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PMID:Streptococcal infection in dogs: a retrospective study of 393 cases. 2038 24

Streptococcal sepsis in neonates is a potentially lethal condition. A wide spectrum of clinical presentations has been often reported in Group B Streptococcal infections in neonates. Bone and joint infections which are caused by Group B Streptococcus are also encountered frequently, but they have not yet been reported in case of Group A Streptococcal infection in neonates. Here, we are reporting a case of septic arthritis and late onset neonatal sepsis which were caused by Group A Streptococcus in a full term, healthy baby.
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PMID:Septic Arthritis caused by Group A Streptococcus in Newborn: An Unusual Presentation. 2390 22