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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is well-known that cirrhosis is a predisposing factor to Yersinia septicemia. This study includes 73 cirrhotics and shows a high number of positive serologic tests (47/73 : 64.4%). However, there is no correlation with clinical features or bacteriological findings. The most frequent serotypes, i.e. pseudotuberculosis IV and enterocolitica 0:9, differ from those which are usually found in Yersinia septicemias. Iron overload in cirrhosis, increased intestinal load of gram-negative bacilli and possible latent bacteremia may partly explain these results. However, the role probably played by as yet poorly known cross-reactions between Yersinia and other pathogens (Shigella, E. Coli...) must be underscored. The authors conclude that slightly positive, stable, serodiagnostic tests have little meaning in cirrhotics.
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PMID:[Serodiagnosis of Yersinia infections in cirrhotic patients. Study apropos of 73 patients]. 631 24

An unusual case of Yersinia pseudotuberculosis septicemia is reported. Diabetes mellitus was the sole underlying disease; liver enzyme elevations were only transitory. The strain did not show motility until after 50 days at room temperature; it showed temperature and media-dependent fermentation of arabinose, melibiose and rhamnose.
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PMID:Yersinia pseudotuberculosis: unusual features of a case. 635 10

A 2-year-old girl with Yersinia pseudotuberculosis septicemia had a large abdominal mass that had to be differentiated from malignant tumor. The mass disappeared rapidly with antibiotic therapy and was defined to be a cluster of enlarged ileocecal lymph nodes by the clinical course and the findings at ultrasonic examination and Gallium scintigraphy.
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PMID:A case of Yersinia pseudotuberculosis septicemia accompanied by a large abdominal tumor. 636 54

The abilities of Yersinia pestis to undergo restriction in Ca2+-deficient medium with concomitant production of V and W antigens (Vwa+) and to absorb exogenous pigments (Pgm+) are established virulence factors. Mutation of Y. pestis to Pgm- is known to promote resistance to pesticin (Pstr) and reduced lethality by peripheral routes of injection. Vwa+ Pgm- isolates of Y. pestis were shown in this study to retain virulence in mice when injected intravenously. Although Pgm- in appearance, wild-type cells of Yersinia pseudotuberculosis and Yersinia enterocolitica may also be sensitive to pesticin. Pstr mutants of Vwa+ strains of these species were similarly of reduced virulence, especially by peripheral routes of injection. The consequences of mutation to Vwa- and Pgm- or Pstr on growth and persistence in vivo were determined. After intravenous injection, Vwa+ yersiniae of all species exhibited sustained growth in mouse spleen, liver, and lung and accumulated in blood. Septicemia was not observed after similar injection of Vwa- mutants which were unable to maintain comparable rates of net increase in tissues. Mutation to Pgm- or Pstr did not influence proliferation but resulted in enhanced clearance from organs. It is known that reticuloendothelial cells serve as favored sites of replication for all wild-type yersiniae. Our results are consistent with the hypothesis that the Vwa+ phenotype favors growth within macrophages and that the Pgm+ and pesticin-sensitive phenotypes permit long-term, probably extracellular, retention within organs. Virulence in standard animal models (mice, rats, and guinea pigs) was not correlated with resistance to the bactericidal action of serum.
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PMID:In vivo comparison of avirulent Vwa- and Pgm- or Pstr phenotypes of yersiniae. 636 86

Yersinioses are zoonoses inspite of the fact, that the pathogen is rarely transferred directly from the animal to man, but mostly from contaminated food or contaminated surroundings. Enteritis or enterocolitis develop in most cases after infection with Y. enterocolitica (enteritic form), whereas pseudoappendicitis accompanied by massive mesenterial lymphadenitis of the ileocecal lymph nodes with or without the participation of adjacent parts of the intestine develops after infection with Y. pseudotuberculosis (pseudoappendicitic form). Some complications like arthritis and erythema nodosum occur rather frequently and may help to establish the diagnosis; septicemia occurs very rarely and is as yet lethal in 50% of cases. Confirmation of yersiniosis is in general not possible on clinical grounds only. Also microscopic as well as macroscopic morphological findings will allow a tentative diagnosis only. Confirmation must come from bacteriologic or serologic findings.
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PMID:[Pathogenesis and pathologic anatomy of human Yersinia infections]. 639 1

The successful isolation of Yersinia pseudotuberculosis from the stool of an asymptomatic family member of a patient with yersinia septicemia is presented. Cold enrichment permitted the isolation after 4 weeks of refrigerator incubatio,.
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PMID:Yersinia pseudotuberculosis: use of cold-temperature enrichment for isolation. 698 99

Six personal observations of aseptic acute arthritis with positive serology for yersinia pseudotuberculosis (YPT) have been related, the specific serodiagnosis was clearly positive (greater than 1/500) for all the patients and the rate variations of repeated examinations were constantly observed. These cases have been compared with 14 sporadic observations of the existing studies where such reactive arthritis were referred to a recent YPT infection, this confrontation leads us to specify the characteristics of this inflammatory rheumatism : starting by a prearthritic phase with variable combination of fever, diarrhea, abdominal pains, erythema nodosum, usually polyarticular affection (90%) mostly of the knees (89%), ankle-joints, wrists and elbows, marked inflammatory clinical and biological signs but without X. Rays abnormalities. The course which seems hastened by anti-inflammatory medication ends up several weeks or months later without recurrences or secondary diseases by a recovery. The presence of HLA B27 antigen in 50% out of the 10 tested cases enables us to discover the intervention of a predisposing genetic factor. A semiologic and nosologic comparison is established with polyarthritis of YEC infection. The discussion concerning the 18 observations where only serology based diagnosis exists, turns mainly on the reality of sporadic YPT rheumatism. If it is not yet possible to assert with certitude the authenticity of such YPT reactive arthritis there is several arguments in support of that, particularly the existence of post-septicemia aseptic polyarthritis and the existence of similar joint-affection during the far-east scarlatiniform fever which is a special form of YPT infection.
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PMID:[Aseptic arthritis with positive serology for Yersinia pseudotuberculosis. Apropos of 6 new cases]. 702 61

Septicaemia caused by Yersinia pseudotuberculosis in a female patient, aged 22, is reported. She had suffered from a chronic active hepatitis for 14 years and had been treated with corticosteroids and azathioprine. The Y. pseudotuberculosis septicaemia responded well to treatment with doxycycline orally, but the patient died 2 weeks later because of excessive bleeding from varicose veins of the oesophagus.
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PMID:Yersinia pseudotuberculosis as the cause of septicaemia in a patient with liver cirrhosis. A case report. 702 Mar 42

Enteral yersiniosis is caused either by Y. enterocolitica 0-group I (syn. serotype 0:3) and 0-group V (syn. serotype 0:9) or Y. pseudotuberculosis type I-VI. The clinical symptoms are mostly like enteritis, enterocolitis, acute abdomen, mesenteric lymphadenitis, or ileitis terminalis. Post-infection reactions are possible like septicemia, arthritis and erythema nodosum. Only cultural and serological examinations confirm the diagnosis of enteral yersiniosis. In the judgement of serological results it is necessary to consider the cross-reactions of Y. enterocolitica 0-group V to Brucella abortus, Brucella melitensis and Brucella suis and also to the antigenic community of Y. pseudotuberculosis type II respectively IV to Salmonella group B respectively D. With exception of septicemia, it is not necessary to treat enteral yersiniosis with antibiotics.
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PMID:[Enteral yersiniosis--a serious disease? Current knowledge of clinical aspects, diagnosis and therapy]. 709 94

Yersinia pseudotuberculosis is an uncommon cause of abdominal pain. It has a much lower incidence than Yersinia enterocolitica, and most reports have emanated from Europe or North America. This report is about a patient with Yersiniosis affecting the appendix alone, in contrast to the usual picture of mesenteric adenitis or septicemia associated with this organism.
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PMID:Yersinia pseudotuberculosis affecting the appendix. 787 53


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