Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cholestasis in a patient with Hodgkin's disease is uncommon, and the causes of cholestasis are mainly direct tumor involvement of the liver, hepatotoxic effects of drugs, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome (VBDS) represents a very rare cause for cholestasis in this disease. We report here on a case of a 45-year-old man who developed VBDS during the complete remission stage of Hodgkin's lymphoma. There was no history of hepatitis or intravenous drug abuse, and the patient had negative results for hepatitis A virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, and human immunodeficiency virus. The serological studies for antinuclear antibodies, anti-mitochondrial antibodies and anti-smooth muscle antibodies were also negative. Liver biopsy disclosed the absence of interlobular bile ducts in 9 of 10 portal tracts without any active lymphocyte infiltration and there were no Reed-Sternberg cell in the liver. The patient's cholestasis was in remission and the serum bililrubin level was normalized after two months without treatment, but tumor recurrence was noted at multiple sites of the abdominal lymph nodes on follow-up abdomino-pelvic computed tomogram.
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PMID:[Spontaneous resolution of vanishing bile duct syndrome in Hodgkin's lymphoma]. 1598 Jun 75

The most frequent infectious disease as in the previous years was influenza. 1,216,285 cases were reported (3,184.4/100,000). Number of foodborne infections and intoxications remains high--20,221 cases (52.9/100,000). 81.6% of them were caused by Salmonella. In 15.5% of them etiologic factor was not found. In this number Campylobacter infections, rarely tested in Poland may be hidden. Especially alarming is number of cases of diarrhea among children 0-2. Seasonality of childhood diarrhea indicates domination of viral infections, most probably rotaviral among them. There was noted decrease of incidence of newly diagnosed cases of viral hepatitis B (4.7/100,000) which dropped to the level of the incidence of viral hepatitis C (5.9/100,000). Hepatitis A remains at the low level (0.39/100,000). Level of newly diagnosed cases of AIDS (116 cases, 0.36/100,000) remains relatively stable for last few years. The major problem is decreasing reporting of possible risk factors. Infectious diseases caused 0.75% of deaths. Mortality from infectious diseases was 7.2/100,000 and was significantly higher among men (9.5) then among women (5.0). In urban settings mortality from infectious diseases was higher (7.3/100,000) then in the country (6.9). As in previous years, the highest number of deaths was caused by tuberculosis and its late sequels (34.4%). Attention should be given to the increased number of deaths due to sepsis (32.3%, without neonatal sepsis).
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PMID:[Infectious diseases in Poland in 2003]. 1619 May 20

Development of jaundice is an ominous prognostic sign, whether it occurs early or late in the months following hematopoietic cell transplant. In the first weeks after transplant, the dominant causes of liver injury are Sinusoidal Obstruction Syndrome (toxic damage resulting from myeloablative conditioning regimens) and cholangitis lenta (cholestasis of sepsis). Later after transplant, cholestasis is more commonly caused by acute graft-vs.-host disease and drugs. Hepatic infections have become uncommon because of the use of prophylactic anti-fungal and anti-viral drugs. Treatment of severe liver dysfunction is often futile in this setting, but prevention of liver injury is feasible. Hepatic sinusoidal injury can be prevented by avoiding sinusoidal toxins as part of conditioning therapy in patients at high-risk. Cholestatic liver damage can be minimized by prophylactic use of ursodiol and by careful drug monitoring. Anti-microbial drugs will prevent most fungal liver infections and viral hepatitis caused by herpesviruses and hepatitis B virus.
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PMID:Advances in prevention and treatment of hepatic disorders following hematopoietic cell transplantation. 1651 32

Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration. Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease. Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients. Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma. Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement. The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases. Three relevant cases are reported and a review of the published literature is made.
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PMID:Hepatotoxicity induced by cyproterone acetate: a report of three cases. 1716 51

Acute liver failure is a rare disease that can cause death in the majority of untreated cases. Sudden loss of liver function in the absence of a preexisting liver disease is considered the true form and has to be distinguished from impaired function following exacerbation of an underlying liver disease (acute or chronic failure). Common causes include acute viral hepatitis, drug induced liver injury (DILI) and toxins. The loss of the excretory and synthetic function of the liver marks the clinical presentation and results in icterus, coagulopathy and encephalopathy. Additionally impairment of renal function and sepsis occur and contribute to the high mortality of this disease. The activation of cell death mechanisms (apoptosis) leading to a reductio of viable, functional liver tissue is considered to be an important pathophysiologic mechanism. Curative therapy of this disease includes liver transplantation that has been performed in Germany for the first time in 1969. In the year 2004 a total of 91 liver transplantation were performed for acute liver failure (10.3% of all transplants) in German transplant centers.
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PMID:[Acute liver failure--medical viewpoints]. 1717 26

Incidence of influenza, the most frequent infectious disease in Poland decreased 72% to 336,919 cases (882.4 per 100,000 population). Number of bacterial foodborne infections and intoxications remain high--19,870 cases (52.0 per 100,000). 79.6% of them were caused by Salmonella. In 17.0% of them etiologic factor was not found. Number of cases of diarrhea among children 0-2 (viral, bacterial and of unknown origin) was 16,361 (2,326 per 100,000). Among them 5,672 were viral. This number includes rotaviral infections as probably the dominant component. There was noted decrease of incidence of newly diagnosed cases of viral hepatitis B (4.1 per 100,000) which'dropped to the level below the incidence of viral hepatitis C (5,6). Hepatitis A remains at the low level (0.25 per 100,000). Level of newly diagnosed cases of AIDS (170 cases, 0.45 per 100,000) is 19% higher then in the previous year. The major problem with HIV reporting is low fraction of reported risk factors. Infectious diseases caused 0.68 % of deaths. Mortality from infectious diseases was 6.5 per 100,000 population and was significantly higher among men (8.6) then among women (4.5). In urban settings mortality from infectious diseases was higher (7.0 per 100,000) then in the country (5.8). In particular districts (voivodeships) mortality indices remained in the range of 4.6 (kujawsko-pomorskie) to 9.8 (lubuskie). The highest number of deaths was caused by tuberculosis and its late sequels (34.2%). Attention should be given to the increased number of deaths due to sepsis (34.0%, without neonatal sepsis).
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PMID:[Infectious diseases in Poland in 2004]. 1724 56

A prerequisite dental evaluation is usually recommended for potential organ transplant candidates. This is based on the premise that untreated dental disease may pose a risk for infection and sepsis, although there is no evidence that this has occurred in organ transplant candidates or recipients. The purpose of this study was to assess the prevalence of dental disease and oral health behaviors in a sample of liver transplant candidates (LTCs). Oral examinations were conducted on 300 LTCs for the presence of gingivitis, dental plaque, dental caries, periodontal disease, edentulism, and xerostomia. The prevalence of these conditions was compared with oral health data from national health surveys and examined for possible associations with most recent dental visit, smoking, and type of liver disease. Significant risk factors for plaque-related gingivitis included intervals of more than 1 yr since the last dental visit (P = 0.004), smoking (P = 0.03), and diuretic therapy (P = 0.005). Dental caries and periodontal disease were also significantly associated with intervals of more than 1 yr since the last dental visit (P = 0.004). LTCs with viral hepatitis or alcoholic cirrhosis had the highest smoking rate (78.8%). Higher rates of edentulism occurred among older LTCs who were less likely to have had a recent dental evaluation (mean 88 months). In conclusion, intervals of more than 1 yr since the last dental visit, smoking, and diuretic therapy appear to be the most significant determinants of dental disease and the need for a pretransplantation dental screening evaluation in LTCs. Edentulous patients should have periodic examinations for oral cancer.
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PMID:Dental health status of liver transplant candidates. 1725 60

In 2005 numerous important modifications were introduced into surveillance of infectious diseases in Poland according to the requirements of European Union. The most important modification was introduction of European case definitions. Concerning list of infectious diseases, all positions recommended by EU are reported in Poland. Incidence of influenza, the most frequent infectious disease in Poland increased 117.7% to 733,234 cases (1921.4 /100,000). Number of cases of diarrhea among children 0-2 (viral, bacterial and of unknown origin) was 20,194 (2834.2 /100,000). Among them 6877 were viral. This number includes rotavirus infections as probably the dominant component. There was noted decrease of incidence of newly diagnosed cases of viral hepatitis B (4.5 /100,000) which dropped to the level below the incidence of viral hepatitis C (7.8 /100,000). Hepatitis A remains at the low level (0.14 /100,000) Level of newly diagnosed cases of AIDS (146 cases, 0.38 /100,000) is 15.6% lower then in the previous year. The major problem with HIV reporting is low fraction of reported risk factors. Infectious diseases caused 0.70% of deaths. Mortality from infectious diseases was 6.8 per 100,000 population and was significantly higher among men (8.9) then among women (4.8). In urban settings mortality from infectious diseases was higher (7.0 per 100,000) then in the country (6.3). In particular districts (voivodeships) mortality indices remained in the range of 4.7 (podlaskie) to 10.2 (lubuskie). With the decreasing trend of deaths due to tuberculosis and increased numbers of deaths from sepsis, for the first time in 2005 number of deaths from sepsis (967; 2.5/100,000, without neonatal sepsis) was bigger than number of deaths from tuberculosis (834; 2.2).
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PMID:[Infectious diseases in Poland in 2005]. 1795 29

Liver disease is a major medical problem in the Kingdom of Saudi Arabia and is mostly due to viral hepatitis. Liver transplantation is the only option for patients with end-stage liver disease offering good long-term survival. The first liver transplant at the King Fahad National Guard Hospital was performed in February 1994 and since then, 40 liver transplants have been performed on 37 patients. Immunosuppression consisted of prednisone combined with cyclosporin (Neoral) or FK 506. Maintenance immunosuppression was with the use of cyclosporin or FK 506 as monotherapy. All, but one patient, survived the surgical procedure; there were no cases of primary non-function; acute cellular rejection occurred in 12 patients all of whom responded to steroids. Pneumonia and biliary sepsis occurred in 12 patients each. A total of 10 patients died, with sepsis being the leading cause of death. The overall graft survival was 73%. Donor shortage continues to be a major limiting factor.
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PMID:Liver transplantation at king fahad national guard hospital riyadh, kingdom of saudi arabia. 1841 35

Viral hepatitis is common in Nigeria and may present with jaundice in pregnancy. The objective of this study was to determine the contribution of viral hepatitis among other aetiological factors, to the development of jaundice during pregnancy. Data on viral hepatitis among gravidae with jaundice in pregnancy over a 10-year period from 1st January 1992 through 31st December 2001 were retrieved and analyzed. Fifty-two cases of jaundice in pregnancy were seen among 16,566 pregnancies registered in the hospital over the 10-year period. Of the 52 cases of jaundice in pregnancy, only 48 case records were retrievable, on which this analysis is based. Viral hepatitis (VH) occurred in 1 in 591.6 pregnancies and was diagnosed in 28 (58.3%) cases of jaundice in pregnancy. Other causes of jaundice were malaria 8 (16.7%), sickle-cell anaemia in pregnancy 6 (12.5%) and sepsis 2 (4.2%). Of the 28 patients with viral hepatitis, 8 (28.5%) were positive for HBsAg. The liver function tests (LFTs) were done in 26 of the 28 patients and it showed hyperbilirubinaemia in 24, 11 had serum albumin >3.5 g/dl. All had spontaneous vaginal delivery with no maternal death. Complications associated with viral hepatitis were, anaemia 14 (50%), intrauterine growth retardation (14.3%), intrauterine foetal death 2 (7.1%), congestive cardiac failure 1 (3.57%) early neonatal death 1 (3.57%) and 2 (7.1%) cases of systemic hypertension. Viral hepatitis contributes significantly to jaundice in pregnancy and there is associated fetal and maternal morbidity.
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PMID:Viral hepatitis in the aetiogenesis of jaundice in pregnancy at the University College Hospital, Ibadan. 1920 72


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