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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An analysis of lethal outcomes following thermal traumas during the recent 8 years has shown sepsis to occupy one of the leading places as a cause of death of burned people. During the recent years the incidence of early sepsis has been increased. This kind of sepsis develops in the period of shock and acute toxemia, is often of lightening character, possesses certain specific morphological features and is caused predominantly by gram-negative flora threatening to patients with critical burns of more than 40% of the body surface.
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PMID:[Characteristics of sepsis in burn patients today]. 293 29

Gangrenous dermatitis caused by Corynebacterium ulcerans developed in 63 of 350 wild Richardson ground squirrels (Spermophilus richardsonii). Six squirrels died of toxemia and/or septicemia, but 57 responded to topical and parenteral administration of antibiotics. The epizo-otic was believed to be associated with fighting; infected and carrier ground squirrels most likely transmitted the C ulcerans through bite wounds. Individuals handling ground squirrels should be cautioned that C ulcerans may produce a diphtheria-like disease in human beings.
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PMID:Gangrenous dermatitis caused by Corynebacterium ulcerans in Richardson ground squirrels. 318 92

The question of general toxemia as an important problem in acute surgery has first been raised. In addition to the infection component attention is called to the presence of a pathologic focus (diseased internal organ) which is the main cause of diffuse peritonitis. Attention is given to sepsis and basedowian goiter with the IV degree thyrotoxicosis followed by pronounced toxemia. In addition to antibacterial therapy the authors recommend transfusion of fresh blood with heparin, forced diuresis, peritoneal dialysis hemosorption, ganglionic blockade with venous antiseptics and other methods to struggle against toxemia. The active tactics of the surgeon is necessary aimed at elimination of the main cause of general toxemia--liquidation of the pathological focus.
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PMID:[Endotoxicosis in surgery]. 342 42

The endogenous intoxication occurring in sepsis, trauma or marked dysfunction of the excretory system is often followed by Acute Pulmonary Injury. A sharp correlation was observed between the loss of the pulmonary function and structure and the blood concentration of active substances, i.e.; toxic peptides and other toxemia metabolites. The humoral and cellular lung injury mediators rate is elevated and the damage of the pulmonary endothelial membranes due to lipids peroxide oxidation reactions is observed. The method for severe lung injury treatment with the help of charcoal hemoperfusion and membrane oxygenation was developed both in experiment and clinic. The advantages of veno-arterial circuit of perfusion in pulmonary circulation, microcirculation stabilisation, reducing both the level of toxic substances entering the lungs and the pulmonary injury mediators capable of damage to the systemic circulation were established. In less harmful lung injury dentero sorption is likely to be used for the detoxication.
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PMID:Lung injury and endogenous intoxication: interrelation and sorption detoxication capacity. 344 Jan 33

The history of maternal deaths in England from the earliest records in the 1700s to 1935, concentrating on the influence of medical practice, is recounted. The rate lay between 4 and 5 per 1000 until 1935, with the advent of sulfa antibiotics to prevent puerperal infections. The practice of midwifery by men began in the early 17th century in Britain, but attendance at normal labors by medical practitioners, that is, surgeon-apothecaries, did not become common, and then only in urban areas, until 1730. The use of forceps became widely known about that time, and lying-in hospitals were begun. Obstetrics was held in contempt by professionally educated and registered physicians and apothecaries, however, because of the immodesty and messiness of the work and the long hours involved. Estimates of maternal mortality, from the 1st recorded unselected series, in the late 18th century range from 5-29/1000. Some of the high figures are from specialists in obstetrics, who treated complicated cases. From these data the maternal death rate was estimated at about 25/1000 among unassisted women. Some institutions achieved results better than the national average in the 1920s, suggesting that by the end of the 18th century, a fairly good understanding of childbirth had been reached. At that time the overall forceps rate was conservative, less than 1% compared to 15% now. Use of the perforator, hook and crochet, and manual dilatation of the cervix had been abandoned. In the 19th century, lying-in hospitals became more common and their death rates were higher, probably due to less conservative methods, up to as high as 85/1000, until the advent of antisepsis in 1880. Nevertheless, hospital births were the minority, amounting to 15% in 1927, 54% in 1946, 87% in 1970, 98.8% in 1980. Sepsis, due to casual use of sterile technique, remained the cause of half the total deaths until 1937. It is difficult to assess the contribution of toxemia or obstructed labor in maternal deaths. Rickets was a common cause of obstructed labor, and there are recorded epidemics of both. Similarly, abortion-related deaths are even more difficult to estimate, because of poor reporting. In evaluating the undiminished maternal death rate before 1935, the author believes that maternal survival is remarkably resistant to the ill effects of socioeconomic deprivation, but is very sensitive to the good and bad effects of medical intervention. Hence, there is evidence that the rural and poor in some cases had better results that those given the best medical assistance, especially with regard to puerperal sepsis. The midwifery laws of 1902 provided for training of midwives, and slowly corrected quality of care, as well as hostility between midwives and physicians. The current maternal death rate is about 0.1/1000.
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PMID:Deaths in childbed from the eighteenth century to 1935. 351 35

796 pregnancies complicated by preeclampsia and 1,299 pregnancies without toxemia of the years 1981 to 1985 have been compared with regard to prematurity. Prematurity rates were 12.4 respectively 13.8 per cent, hypotrophy rates were 20 resp. 13 per cent, acidosis morbidity was 75 resp. 20 per cent and Apgar values below 8 were 63 resp. 24 per cent. Morbidity rate of respiratory distress syndrome was 8 resp. 12 per cent, of sepsis 2 resp. 7 per cent, intrauterine death rate 5 resp. 2 per cent, but survival rate overall was 93 resp. 90 per cent. Prematurity was influenced by severity of preeclampsia, time of onset and prenatal care. Prolongation of pregnancy by tocolysis is possible principally, but influenced in its effect by maternal and fetal symptoms and the necessity of termination of pregnancy by these factors.
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PMID:[Premature labor in gestosis]. 356 53

Numerous studies have identified perinatal risk factors of neonatal sepsis. Some authors have attempted to develop a score system and have shown that babies with septicemia usually had a significantly higher score than healthy newborns and infants with other diseases. The aim of our study is to verify the validity of a scoring method based on the following items: maternal disease; e.g. diabetes, severe toxemia, infection; rupture of the membranes more than 24 hours before the delivery; foul-smelling amniotic fluid; complicated delivery; Apgar score less than 7; umbilical catheterization; respiratory distress and other neonatal diagnoses leading to operative procedures. We have evaluated four groups of babies, full-term AGA and SGA and preterm AGA and SGA, 84 with septicemia, 105 with other diseases and 210 healthy newborn infants. None of the perinatal risk factors or neonatal diseases was sufficiently predictive of neonatal septicemia. Only the incidence of umbilical catheterization was significantly higher (p less than 0.01) in preterm AGA (37.1%) and SGA (64.7%) babies with septicemia than in preterm healthy AGA (2.8%) and SGA (7.7%) babies; on the contrary, no statistical differences were found between preterm AGA (37.1%) and SGA (64.7%) infants with septicemia and preterm AGA (42.8%) and SGA (66.6%) infants with other neonatal diseases. A score of 1 was assigned for each of the considered items. In the full-term infants a score of 1 or less was found in 100% of the healthy infants. A score of 2-3 was found in 26% of the septicemic infants and in 42% of the infants with other diseases.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Neonatal sepsis and perinatal risk factors]. 372 13

73 cases of anthrax were recorded by the Health Office in the Sivas region in the last 4 years. This paper presents a rare and severe clinical form of anthrax displaying diagnostic difficulties. Six women aged between 16-46 were diagnosed as having throat anthrax and treated in the Infectious Diseases Department of Cumhuriyet University. The lesions were localized on the tonsils in 5 cases and on the base of the tongue in 1 case. The main clinical features were sore throat, dysphagia, fever, regional lymphadenopathy on the neck and toxemia. Three patients died with toxemia and sepsis. The diagnosis was confirmed by the isolation of Bacillus anthracis.
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PMID:Primary throat anthrax. A report of six cases. 377 69

The charts of all newborns at the University of the East Medical Center in the Philippines were obtained and were matched with the mother's charts in a study designed to identify the causes of perinatal morbidity and mortality and to analyze the factors that lead to such results. There were 4219 deliveries of 28 weeks and later or 1000 grams and more during 1980-82; only 4057 were available for study. There were 39 neonatal deaths from 4015 live births giving a neonatal death rate of 9.7/1000 live births. Late fetal deaths or stillbirths occurred in 42 fetuses out of 4057 total births with a stillbirth rate of 10.3. There were in all 81 perinatal deaths from 4057 total births with a perinatal mortality of 19.99. There were 250 morbid babies out of 4015 live births giving a morbidity rate of 62.3/1000 live births. Compared to national statistics, the results at this institution are expectedly lower, due to fewer patients with more facilities and personnel. The most common cause of neonatal mortality in the 39 cases was sepsis, which occurred in 21 cases or 53.8%. This was followed by prematurity with hyaline membrane disease in 13/39 or 33.3% of cases and asphyxia in 4/39 or 10.3%. Lethal congenital anomalies occurred in only 1/39 or 2.6% of cases. Stillbirth or late fetal deaths occurred in 42 cases or over 1/2 of total perinatal mortality cases. In 23 of the 42 cases or 54.8%, the cause was cord accidents. In 11/42 or 26.2% of cases, the cause of fetal death was severe asphyxia due to abruptio placenta, severe toxemia giving rise to placental insufficiency, or obstructed labor. In 3/42 or 7.1%, lethal anomalies was the cause; in 5/42 or 11.9% the cause was unknown. Of the total causes of fetal deaths, only those due to asphyxia may be preventable to some extent; these cases comprise only 26.2% of the whole group. Perinatal morbidity was identified in 250 live births. Review of the maternal conditions giving rise to a 25% or more rate of neonatal morbidity shows that multiple pregnancy was foremost with a 60% rate, fetal distress with a 43% rate, premature rupture of membranes with a 38% rate, chronic toxemia with a 31% rate, and placenta previa with a 28% rate. Morbidity and mortality can be lowered markedly with improved prenatal care and early detection and treatment of complications which interact with socioeconomic status and other social differentials.
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PMID:Perinatal morbidity and mortality in the Philippines. 377 13

Rubber band ligation of hemorrhoids has had a low incidence of complications until recently, when five deaths resulted from bacterial septicemia or toxemia. The case presented describes a severe soft-tissue infection following banding successfully treated with antibiotics, surgical debridement, and hyperbaric oxygen.
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PMID:An unusual complication of rubber band ligation of hemorrhoids. 380 21


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