Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two sources of septic toxemia--microbial and metabolic--were found in a detailed analysis of 37 patients with pronounced symptoms of sepsis. The proposed three-degrees classification of septic toxemia based upon the degree of clinical signs and humoral reactions, gives sufficient information, partically useful for a more objective estimation of the patients' state, to choose a purposeful therapy of sepsis and real ideas of the prognosis. In addition to the active antimicrobial therapy with using powerful antiseptics (sulfamilon, chlorophilipt, gentamycin, ceporin etc.) the authors insist on hemotransfusions (direct hemotransfusions included) in order to liquidate progressing anemia and to perform nonspecific detoxication by means of forced diuresis or peritoneal dialysis according to the techniques developed by the authors.
 ...
PMID:[Clinical characteristics of sepsis today]. 52 95

The origin, background, and mechanism of operation of the Maternal Mortality Study Committee in Wisconsin is outlined. Its value as a teaching vehicle is emphasized. Trends in maternal mortality in Wisconsin and the continued decline are presented, with 45 per 100,000 live births in 1953 to 9.2 per 100,000 live births in 1975. An appeal for standardization of terms and definitions and a continuation of these studies in each state is made. Study committees in many states are inactive. It is suggested that chairmen of maternal mortality committees in many states are inactive. It is suggested that chairmen of maternal mortality committees and representatives meet in geographic areas comparable to Districts of The American College of Obstetricians and Gynecologists to compare trends and statistics. Hemorrhage, once considered the important cause, has decreased from 56.4% of maternal loss to a low of 12.1% in 1975. Presently, a category listed as "other causes"--that is, other than hemorrhage, sepsis, and toxemia--account for approximately 60% of deaths. This group includes anesthesia, emboli and coincidental disease involving kidneys, heart, malignancy, and diabetes. An appeal is made to continue these studies.
 ...
PMID:Mothers are still mortal. 70 97

After a brief survey of some physiologic properties of Von Willebrand factor activity (VIII r WF) the numerous clinical states with an increase of this activity are described. The authors report their own results concerning sepsis, chronic arteritis of lower limbs, diabetes, toxemia of pregnancy. In most cases the increase of VIII r WF activity appears as a sign of vascular injury and/or the consequence of tissular damage.
 ...
PMID:[Von Willebrand factor activity and thrombophilic states. A review (author's transl)]. 79 10

Forty-eight 32-week-old meat-type females, free from Mycoplasma synoviae (Ms.) and Mycoplasma gallisepticum (Mg.) were aerosol exposed with a 24-hour broth culture of Ms. 1331 and placed in 3 pens. 16 birds per pen. Two males were placed in each of the 3 pens and used as contact birds. All birds were bled at 2, 4, 7, 10, 14, 24, 26, and 30 weeks post Ms. exposure. After the 24-week bleeding, the females were equally divided into 4 pens. All females in 2 of the pens were given a foot pad injection of 0.3 ml. of Ms. 1331 broth culture. Ms. isolation attempts were made from the trachea of all birds at 2, 14, and 24 weeks post Ms. exposure. Ms. isolation attempts were made from all eggs produced, either from the allantoic fluid and egg yolk of 17- or 18-day-old embryos, dead embryos, and infertile eggs, or from the tracheas of day-old progenies. Each day-old progeny was bled. Ms. and Mg. serum plate tests were conducted on the serums from the progeny and adult birds from each bleeding. Ms. hemagglutination-inhibition (HI) tests were conducted on the serums of the adult birds. In the Ms.-exposed birds, the geometric mean HI titer of the serums from each bleeding rose significantly over the previous bleeding. The percentages of Ms. serum plate reactions increased with length of time after Ms. exposure. There were false Mg. serum plate reactions in the early stages of Ms. infection. A foot pad challenge with a broth culture of Ms. 1331 24 weeks after Ms. exposure did not significantly increase the geometric mean HI titer over the Ms. exposed birds that did not have a Ms. foot pad challenge. Ms. was isolated from the trachea of 91.6%, 100%, and 100% of the Ms.-exposed birds at 2, 14, and 24 weeks after Ms. exposure, respectively. There were 35 Ms. isolates from 575 attempts from 17- or 18-day embryos, dead embryos, or infertile eggs, and 7 Ms. isolates from 67 attempts from the trachea of day-old progenies. All isolates were made from eggs collected from 6 through 31 days afer Ms. exposure. No isolations were made from 1760 attempts made from eggs collected from 32 through 210 days after Ms. exposure, including eggs collected from Ms. foot pad-challenged birds at 168 days after Ms. exposure. There were 312 broilers reared from eggs collected from the 22 through 24 weeks after Ms. exposure. The broilers were marketed at a federally inspected poultry processing plant. Their records showed 3 birds condemned for septicemia-toxemia, but none were condemned for air-sacculitis or synovitis. Twenty-four serums from the broilers that were positive to Ms. or Mg. serum plate tests were all negative to the Ms. and Mg. HI tests. Ms. serum plate reactors began to show up in the day-old progeny from eggs collected beginning on the 76th day after Ms. exposure. There were 16.0% (80/500) positive to the Ms. serum plate test from eggs collected from the 76 through 126 days after Ms. exposure and 14.0% (52/372) from eggs collected from the 169 through 210 days after Ms. exposure.
 ...
PMID:The resistance and carrier status of meat-type hens exposed to Mycoplasma synoviae. 93 89

Acute renal failure of obstetric origin is common among North Indian patients and comprised 72 (22.1%) of 325 patients undergoing dialysis over an 11-year period. Of these, 46 gravidas had developed renal failure following abortion, and 29 cases were due to complications of late pregnancy. The most striking feature of this study was a high incidence of irreversible renal lesions of bilateral diffuse cortical necrosis in early (18.6%) as well as late pregnancy (37.8%). Overall incidence of diffuse cortical necrosis was 25%. In the remainder, acute tubular necrosis was seen in 52 (72.2%), patchy cortical necrosis in 1 (1.4%), and tubular necrosis along with glomerular involvement in 1 patient (1.4%). Pathogenetic factors which contributed to the development of renal failure, either singly or in combination, were loss of blood failure, either singly or in combination, were loss of blood (79.1%), septicemia (31.9%), hypotension due th hemorrhagic and septicemic shock (51.4%), eclamptic toxemia (11.1%), and disseminated intravascular coagulation in 12.5% patients. Infrequent occurrence of disseminated intravascular coagulation in the septic anc eclamptic patients who developed diffuse cortical necrosis was an interesting finding, as was the fact that coagulopathy was more frequently observed in acute tubular necrosis. Late referral, frequent sepsis, and high incidence of bilateral diffuse cortical necrosis contributed significantly to a high mortality (55.3%).
 ...
PMID:Acute renal failure of obstetric origin. 108 92

A successfully treated case of acute fulminating necrotizing amebic colitis characterized by signs of toxemia, septicemia and peritonitis is reported. Early diagnosis and staged surgical procedures apparently lower the mortality. Intensive antiamebic therapy should be instituted as soon as amebiasis is confirmed, otherwise surgical therapy is likely to fail.
 ...
PMID:Massive necrosis and perforation of the colon in amebiasis. 114 96

It was shown in a group of 59 patients with large thermic injuries that neither surgical treatment and the type of anesthesia and/or possibly some other therapy such as modern antibiotics, nor the age factor influence significantly liver changes which can almost always be found in burns disease. Undoubtedly, primarily the period of sepsis or toxemia has an unfavourable hepatotrophic effect - the decisive role being played by the bacterial infection of wound surfaces. A clinical laboratory and morphological picture of liver changes is given.
 ...
PMID:Liver changes in burns, as seen in the clinical morphologic picture. 127 16

Toxic shock syndrome (TSS), first described by Todd et al. in 1978, can be a life-threatening entity. Familiarity with the pathogenesis and clinical presentation of TSS may help achieve early diagnosis and prompt appropriate intervention. TSS is not a septicemia, but a toxemia. The most extensively described pathogenesis involves a focus of specific Staphylococcus aureus strains capable of producing an exotoxin (TSST-1). We report two patients who developed TSS while in external fixators and describe their initial symptoms, management, and subsequent problems. This report will serve to alert pediatric orthopaedic surgeons to this entity and enable them to recognize its rather precipitous presentation and initiate appropriate treatment.
 ...
PMID:Toxic shock syndrome in patients with external fixators. 151 30

We describe two patients with group A beta hemolytic streptococcal septicemia from minor foci in the skin. They developed extreme toxemia, mental obtundation and multi-system organ failure associated with diffuse erythema. They both survived after appropriate antibiotic and intense supportive therapy. These are examples of the "toxic strept syndrome" which is similar to staphylococcal toxic shock.
 ...
PMID:The toxic strept syndrome: two case reports. 141 83

A profound analysis of 32 cases of general purulent infection that led to aggravation of multiple gunshot injuries proves the pathogenetical connection between the character of trauma, health status of patient and possibility for sepsis development. The main factors which determine the appearance and the course of wound sepsis are the following: the character of reaction of the organism to trauma, volume of invaded tissues, adequacy of health care, type and virulence of agents of the infection. The state of vital systems of human organism as well as the possibilities of medical care play an important role in the sepsis development in the acute period of wound illness. The major part of repeated interventions was conditioned by defects of the first surgical management. The opportune diagnosis on an early phase of sepsis, i.e. toxemia, is of great importance for the determining of tactics for the treatment and for complex intensive therapy in which hyperbaric oxygenation will assume a key role.
 ...
PMID:[The pathogenetic and treatment characteristics of general suppurative infection in multiple gunshot wounds]. 195 96


1 2 3 4 5 6 7 8 9 Next >>