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Query: UMLS:C0036690 (sepsis)
 59,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The risks of acute pyelonephritis in infants concern microbial invasion and parenchymal damage. There is a high rate of septicemia and of urinary malformations in children under 1 yr of age; in addition, the kidney is a growing organ with a high risk of scarring. Such parenchymal injury may lead to arterial hypertension, and renal failure when bilateral. Vesicoureteric reflux must be evaluated by ultrasound and cystogram; long-term renal scarring needs to be assessed by scintigraphy or pyelography when children are 7 yr old. Short- and long-term risks could be limited by early intravenous biantibiotherapy.
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PMID:[Urinary tract infections in infants: medical management]. 166 85

The Prune Belly syndrome (PBS) is unfrequent. Fourteen cases have been followed in our unit during the last 20 years. Four infants (29%) died during the first months of life, because of neonatal sepsis (2 cases) or end-stage renal failure (2 cases). Among the other 10 cases, 6 (43%) had normal glomerular filtration rate at a mean age of 10 years 6 months (6 months to 15 years), 4 had chronic renal failure, including 3 cases who developed end-stage renal failure at 8, 8 years 8 months and 17 years respectively. Resection of an urethral obstruction was performed in 2 cases. This surgical indication remains widely accepted, while the current tendency is to limit ureteral surgery in PBS. Orchidopexy was performed in 4 children, 3 of them less than 6 years 6 months of age. Fertility of these early operated children remains to be established, as all adults reported in the literature remain sterile when orchidopexy was not performed or was performed after age 6.
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PMID:[Prognosis of prune belly syndrome]. 168 92

Advances in medical technology and knowledge have influenced morbidity and mortality in surgically treated diseases. The authors have compiled four consecutive retrospective studies of demography, morbidity and mortality of patients with acute pancreatitis to summarize the experience from 1956 to 1985 at the Montreal General Hospital with 629 patients. The death rate has remained unchanged. Hypotension, gastrointestinal bleeding and respiratory failure have assumed lesser roles as major complicating factors. Renal failure and gram-negative aerobic pancreatic sepsis are the common causes of death. The last two reviews revealed that surgical debridement and drainage combined with appropriate biliary procedures salvaged two-thirds of the patients with sepsis. Deteriorating nutritional status, heralded by a fall of serum albumin level below 30 g/L, is associated with a poor prognosis. Interval cholecystectomy in patients with mild biliary tract pancreatitis is associated with a low death rate (0.01%).
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PMID:Acute pancreatitis--30 years' experience at a teaching hospital. 202 95

As newer treatment modalities become available for patients with severe lupus nephritis, it becomes increasingly important to identify patients at risk for renal failure. In this study, the records of 90 children presenting with systemic lupus erythematosus over a 13-year period were reviewed. Nineteen were lost to follow-up prior to completion of the study. Of the 71 remaining children, 16 (22%) progressed to chronic renal failure. Persistent hypertension lasting greater than 4 months, anemia, abnormalities of the urinalysis, and elevated serum creatinine level were significantly associated with progression to renal failure. Sex, race, age, abnormalities of creatinine clearance, and 24-hour urine protein collection were not associated with progression to renal failure. Renal biopsies were obtained in 45 children. Biopsies were initially classified according to World Health Organization criteria. Diffuse proliferative glomerulonephritis was significantly associated with progression to renal failure. The 45 biopsies available were reviewed by one of the authors and categorized by activity and chronicity indices. Both the active lesions of fibrinoid necrosis, synechiae, tubular casts, and vasculitic lesions and the chronic lesion of glomerular sclerosis correlated with progression to renal failure. Of the 16 children who progressed to renal failure, 2 had cadaver kidney transplants and are well 5 years posttransplant; 4 had fulminant lupus and died within 1 month of commencing dialysis; 10 began chronic dialysis. Five of the 10 children on chronic dialysis died from sepsis. These data suggest that children with systemic lupus erythematosus who undergo dialysis do poorly.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Lupus nephritis: prognostic factors in children. 140 32

Generalized faecal peritonitis is associated with a mortality of over 50% in most series of cases. Despite great improvements in the standards of intensive care the morbidity and mortality associated with this condition have not improved, in part due to recurrent intra-abdominal sepsis. This preliminary study investigated the role of laparotomy, repeated abdominal lavage and debridement to determine whether such a policy might lead to an improvement in outcome. Of six cases studied three had perforated diverticular disease, two had Crohn's disease. Twenty lavages were performed on these six patients who had a mean ICU stay of 8 days. Five out of the six patients left hospital and remain well, one patient died of septicaemia and pre-existing renal failure. This study found that laparotomy, repeated abdominal lavage and debridement may be effective in reducing the morbidity and mortality of generalized faecal peritonitis and further study of this technique is appropriate.
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PMID:Management of generalized faecal peritonitis--can we do better? 129 27

We reviewed the clinical histories of 14 patients diagnosed of acute obstructive renal failure due to bilateral or unilateral uric calculi in patients with only one functioning kidney for a period of 14 years (1974-1987). Urine was alkalinized in all patients. The increase in urine pH was effective in resolving the obstruction in 12 patients. The alkalinizing methods which succeeded in permeabilizing the urinary tract, considering each functioning kidney independently were: intravenous in 5/21, upstream urethral catheterism in 9/21 and by nephrostomy catheter in 5/21. Surgery was performed in 2 patients. In the later the calculi were of double composition. The most frequent complications were: urinary infection in 7/14 patients, chronic renal failure in 4/14 patients, sepsis in 3/14 patients and bacteremia in 2/14 patients. None of the patients died.
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PMID:[Uric acid calculi: infrequent cause of acute renal failure]. 174 1

When cardiac or pulmonary arrest occurs in hospitalized patients, cardiopulmonary resuscitation (CPR) is often futile. Although "do-not-resuscitate" orders are widely used and presumably screen out many patients who are poor candidates for CPR, recent studies have shown that an average of only 13 percent of patients receiving CPR in the hospital survive to discharge. An average of 4 percent of patients receiving CPR in general ward settings survive. Of those who do survive after CPR, many are in a persistent vegetative state or a chronic dependent condition. Patients with malignancy, sepsis, pneumonia, renal failure, diabetes or advanced age have a low chance of surviving after CPR. It is important for both patients and physicians to make a realistic appraisal of the likely outcome of CPR.
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PMID:CPR in hospitalized patients: when is it futile? 163 86

A 54-year-old man received insertion of an acupuncture needle into the region extending from the posterior neck to the back on two occasions for the treatment of shoulder stiffness. Two weeks after the second acupuncture, he developed fever, dysarthria and mictionary disturbance, finally reaching the condition of tetraplegia. He was immediately admitted to an emergency room in our hospital, and was diagnosed as sepsis with DIC, ARDS, heart failure, renal failure, liver failure, and myelitis. After one month, he recovered with transverse myelopathy as a residual deficit. Neurological findings showed transverse myelopathy below the level of Th2 at that time. Cervical CT revealed an irregular low density at the periphery of the cervical vertebra from the C2 to C4 level. Cervical MRI revealed an irregular swelling of his spinal cord from the C2 to C7 level. We explained the mechanism of transverse myelopathy in this case as follows. After the acupuncture, he suffered a focal infection of the region of needle insertion, and then the infection expanded to the cervical vertebra, thus causing osteomyelitis, sepsis, and finally cervical myelitis. Direct injury of the spinal cord and nerve roots as a complication of acupuncture was previously reported, but indirect injury of the spinal cord due to myelitis had not been reported except our present case. Careful attentions should be paid to the complications of acupuncture.
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PMID:[A case of transverse myelopathy caused by acupuncture]. 178 54

A case of severe neonatal sepsis due to intrauterine infection with Capnocytophaga ochracea, complicated by hypotension, renal failure and disseminated intravascular coagulation, is reported. The role of Capnocytophaga as an organism of increasing importance in intrauterine and peripartum infections is discussed.
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PMID:Severe intrauterine infection due to Capnocytophaga ochracea. 179 20

The work deals with the results of retrospective analysis of infectious complications (IC) in 323 patients with terminal renal failure (TRF) who underwent 371 operations for allotransplantation of cadaver kidney (ATCK). IC frequency was 41%, their mortality, 42.6%. The structure of the IC was as follows: pulmonary 29.6%, wound 22.4%, urinary 20.4%, sepsis 19.1%, others 8.5%. Gram-negative microorganisms predominated in the etiology of the IC; gram-positive cocci, microbial associations, yeastlike fungi, and cytomegalovirus were encountered less frequently. The development of IC did not depend on the patients' sex, primary disease of the kidneys which led to TRF, or the duration of previous treatment by hemodialysis, but was directly related to the age of the recipients. It was found that the character of the basic and anticrisis immunosuppressive therapy influenced the frequency of IC occurrence. The authors recommend some preventive and therapeutic measures for reducing the risk of the development of IC in patients after ATCK.
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PMID:[Infectious-inflammatory complications in patients after transplantation of the kidney]. 180 7


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